Cover 2 - Masthead
(Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - April 1, 2018 Category: Urology & Nephrology Source Type: research

Editorial Board
(Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - April 1, 2018 Category: Urology & Nephrology Source Type: research

Table of Contents
(Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - April 1, 2018 Category: Urology & Nephrology Source Type: research

Myeloid-derived suppressors cells (MDSC) correlate with clinicopathologic factors and pathologic complete response (pCR) in patients with urothelial carcinoma (UC) undergoing cystectomy
Myeloid derived suppressor cells (MDSC) are heterogeneous immunosuppressive cells with potential predictive and prognostic roles in cancer. The association between MDSC, clinicopathologic factors, and pathologic response in patients with bladder urothelial carcinoma (UC) was explored. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - March 29, 2018 Category: Urology & Nephrology Authors: Moshe C. Ornstein, Claudia Marcela Diaz-Montero, Patricia Rayman, Paul Elson, Samuel Haywood, James H. Finke, Jin S. Kim, Paul G. Pavicic, Marcelo Lamenza, Sarah Devonshire, Priscilla Dann, Kim Schach, Andrew Stephenson, Steven Campbell, Hamid Emamekhoo, Tags: Seminars Article Source Type: research

High expression of long noncoding RNA NORAD indicates a poor prognosis and promotes clinical progression and metastasis in bladder cancer
To explore the function of NORAD in bladder cancer (BC), and to verify whether NORAD could be used as a biomarker to determine preoperative presence of progression and lymph node metastasis. To our knowledge, it is the first study investigating NORAD and its implications in BC. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - March 28, 2018 Category: Urology & Nephrology Authors: Qiaqia Li, Chao Li, Jinbo Chen, Peihua Liu, Yu Cui, Xinyi Zhou, Huihuang Li, Xiongbing Zu Tags: Original article Source Type: research

Star Reviewers for Urologic Oncology
(Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - March 28, 2018 Category: Urology & Nephrology Source Type: research

High expression of long noncoding RNA NORAD indicates a poor prognosis and promotes clinical progression and metastasis in bladder cancer
To explore the function of NORAD in bladder cancer (BC), and to verify whether NORAD could be used as a biomarker to determine preoperative presence of progression and lymph node metastasis. To our knowledge, it is the first study investigating NORAD and its implications in BC. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - March 28, 2018 Category: Urology & Nephrology Authors: Qiaqia Li, Chao Li, Jinbo Chen, Peihua Liu, Yu Cui, Xinyi Zhou, Huihuang Li, Xiongbing Zu Tags: Original article Source Type: research

Star Reviewers for Urologic Oncology
(Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - March 28, 2018 Category: Urology & Nephrology Source Type: research

Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1
We recently determined that a novel oncogene, IPO11 from 5q12, participates in bladder cancer (BCa) progression. However, the biological function of IPO11 and the molecular mechanisms through which it contributes to BCa progression remain unclear. The aim of this study was to investigate the role of IPO11 in BCa aggressiveness and elucidate the molecular mechanisms underlying its effects in BCa. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - March 27, 2018 Category: Urology & Nephrology Authors: Junjie Zhao, Lei Shi, Shuxiong Zeng, Chong Ma, Weidong Xu, Zhensheng Zhang, Qingzuo Liu, Peng Zhang, Yinghao Sun, Chuanliang Xu Tags: Original article Source Type: research

Pattern of node metastases in patients treated with radical cystectomy and extended or superextended pelvic lymph node dissection due to bladder cancer
Pelvic lymph node dissection (PLND) has a diagnostic and therapeutic role during radical cystectomy in bladder cancer patients. However, at the time, no prospective data supports the value of extended PLND in improving survival expectances. We sought to describe incidence and location of node metastases in patients treated with extended and superextended PLND. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - March 27, 2018 Category: Urology & Nephrology Authors: Marco Moschini, Emilio Arbelaez, Julian Cornelius, Agostino Mattei, Shahrokh F. Shariat, Paolo Dell ′Oglio, Emanuele Zaffuto, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina Tags: Original article Source Type: research

Role of lymph node dissection in renal cell cancer
Lymph node metastasis in renal cell cancer (RCC) portends an extremely poor prognosis. Despite proven staging benefit, the therapeutic value of lymph node dissection in RCC remains questionable. The only prospective randomized trial examining its role failed to show any benefit. However, subsequent retrospective publications have attempted to identify high-risk cohorts and clinical scenarios where removal of nodes may improve survival. The aim of this article is to provide a comprehensive review looking at the role of lymph node dissection in RCC if any, the ideal extent of dissection, and also tools a clinician could empl...
Source: Urologic Oncology: Seminars and Original Investigations - March 27, 2018 Category: Urology & Nephrology Authors: Nirmal Thampi John, Kyle A. Blum, A. Ari Hakimi Tags: Seminars article Source Type: research

Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1
We recently determined that a novel oncogene, IPO11 from 5q12, participates in bladder cancer (BCa) progression. However, the biological function of IPO11 and the molecular mechanisms through which it contributes to BCa progression remain unclear. The aim of this study was to investigate the role of IPO11 in BCa aggressiveness and elucidate the molecular mechanisms underlying its effects in BCa. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - March 27, 2018 Category: Urology & Nephrology Authors: Junjie Zhao, Lei Shi, Shuxiong Zeng, Chong Ma, Weidong Xu, Zhensheng Zhang, Qingzuo Liu, Peng Zhang, Yinghao Sun, Chuanliang Xu Tags: Original article Source Type: research

Pattern of node metastases in patients treated with radical cystectomy and extended or superextended pelvic lymph node dissection due to bladder cancer
Pelvic lymph node dissection (PLND) has a diagnostic and therapeutic role during radical cystectomy in bladder cancer patients. However, at the time, no prospective data supports the value of extended PLND in improving survival expectances. We sought to describe incidence and location of node metastases in patients treated with extended and superextended PLND. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - March 27, 2018 Category: Urology & Nephrology Authors: Marco Moschini, Emilio Arbelaez, Julian Cornelius, Agostino Mattei, Shahrokh F. Shariat, Paolo Dell ′Oglio, Emanuele Zaffuto, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina Tags: Original article Source Type: research

Role of lymph node dissection in renal cell cancer
Lymph node metastasis in renal cell cancer (RCC) portends an extremely poor prognosis. Despite proven staging benefit, the therapeutic value of lymph node dissection in RCC remains questionable. The only prospective randomized trial examining its role failed to show any benefit. However, subsequent retrospective publications have attempted to identify high-risk cohorts and clinical scenarios where removal of nodes may improve survival. The aim of this article is to provide a comprehensive review looking at the role of lymph node dissection in RCC if any, the ideal extent of dissection, and also tools a clinician could empl...
Source: Urologic Oncology: Seminars and Original Investigations - March 27, 2018 Category: Urology & Nephrology Authors: Nirmal Thampi John, Kyle A. Blum, A. Ari Hakimi Tags: Seminars article Source Type: research