Urologic Oncology: Seminars and Original Investigations This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Intratumor heterogeneity in prostate cancer
Prostate cancer (PCa) has long been thought of as a disease with a heterogeneous phenotype. It can manifest in men as benign growths that can be safely watched or as more aggressive malignancies that can prove fatal. Recent investigations at the genomic, histopathological and molecular levels have identified tumor heterogeneity, the phenomenon of individual tumor cells presenting distinct genomic and phenotypic characteristics, as one of the most confounding and complex factors underlying PCa diagnosis, prognosis, and treatment. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 7, 2018 Category: Urology & Nephrology Authors: Shalini S. Yadav, Jennifer A. Stockert, Victoria Hackert, Kamlesh K. Yadav, Ashutosh K. Tewari Tags: Review article Source Type: research

Effectiveness of a transrectal prostate needle biopsy protocol with risk-tailored antimicrobials in a veterans cohort
To prospectively implement a prostate biopsy protocol to identify high-risk patients for bleeding or infectious complications and use risk-tailored antimicrobials, patient education, and postbiopsy monitoring with the objective of reducing complications. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 7, 2018 Category: Urology & Nephrology Authors: Kimberly A. Maciolek, Sara L. Best, Vania Lopez, Natasza Posielski, Margaret Knoedler, Wade A. Bushman, David F. Jarrard, Tracy M. Downs, E. Jason Abel, Kyle A. Richards Tags: Original article Source Type: research

Effect of multimodal analgesia with paravertebral blocks on biochemical recurrence in men undergoing open radical prostatectomy
The objective of this study is to determine the association between the use of a multimodal analgesic approach incorporating paravertebral blocks and risk of biochemical recurrence following open radical prostatectomy. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 7, 2018 Category: Urology & Nephrology Authors: Liam C. Macleod, Robert M. Turner, Samia Lopa, Lee A. Hugar, Benjamin J. Davies, Bruce Ben-David, Jacques E. Chelly, Bruce L. Jacobs, Joel B. Nelson Tags: Original article Source Type: research

Increasing rate of lymph node invasion in patients with prostate cancer treated with radical prostatectomy and lymph node dissection
To investigate lymph node invasion (LNI) rates in prostate cancer (PCa) patients. Recent studies demonstrated an inverse stage migration in PCa patients toward more advanced and unfavorable diseases. We hypothesized that this trend is also evident in LNI rates, in PCa patients treated with radical prostatectomy (RP) and pelvic lymph node dissection (PLND). (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 7, 2018 Category: Urology & Nephrology Authors: Felix Preisser, Sebastiano Nazzani, Marco Bandini, Michele Marchioni, Zhe Tian, Francesco Montorsi, Fred Saad, Alberto Briganti, Thomas Steuber, Lars Bud äus, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I. Karakiewicz Tags: Original article Source Type: research

FGF-2 is a driving force for chromosomal instability and a stromal factor associated with adverse clinico-pathological features in prostate cancer
There is mounting evidence to suggest that stromal cells play an integral role in the progression of prostate cancer (PCa). One of the most frequently altered growth factors in PCa is fibroblast growth factor-2 (FGF-2). It has previously been proposed that early stages of PCa are characterized by a primarily exogenous, that is, stromal cell-derived FGF-2 production, whereas advanced tumors rely more on an autocrine FGF-2 production. Prostate cancer progression is characterized by an increase of genomic instability including aneuploidy and structural chromosomal alterations. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 7, 2018 Category: Urology & Nephrology Authors: Carine Pecqueux, Aysenur Arslan, Martina Heller, Michael Falkenstein, Adam Kaczorowski, Yanis Tolstov, Holger S ültmann, Carsten Grüllich, Esther Herpel, Anette Duensing, Glen Kristiansen, Markus Hohenfellner, Nora M. Navone, Stefan Duensing Tags: Original article Source Type: research

An evaluation of race, ethnicity, age, and sex-based representation in phase I to II renal cell carcinoma clinical trials in the United States
Enrollment of a representative study population permits generalizable and reliable results for clinical trials. We sought to evaluate whether patients enrolled in trials for advanced renal cell carcinoma (RCC) are representative of the overall population of advanced RCC patients in the United States. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 6, 2018 Category: Urology & Nephrology Authors: Alain Kaldany, Kyle A. Blum, David J. Paulucci, Alp Tuna Beksac, Isuru Jayaratna, John P. Sfakianos, Ketan K. Badani Tags: Original article Source Type: research

Temporal trends in venous thromboembolism after radical cystectomy
To determine whether the rate of venous thromboembolism (VTE) following radical cystectomy (RC) is changing overtime. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 6, 2018 Category: Urology & Nephrology Authors: Timothy D. Lyon, Matthew K. Tollefson, Paras H. Shah, Katherine Bews, Igor Frank, R. Jeffrey Karnes, R. Houston Thompson, Elizabeth B. Habermann, Stephen A. Boorjian Tags: Original article Source Type: research

Prognostic role of pretreatment neutrophil-to-lymphocyte ratio (NLR) in patients with non –muscle-invasive bladder cancer (NMIBC): A systematic review and meta-analysis
The aim of this study was to summarize and analyze the current evidence regarding the prognostic and predictive value of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients undergoing transurethral resection of bladder tumors (TURBT) for non –muscle-invasive bladder cancer (NMIBC). (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 5, 2018 Category: Urology & Nephrology Authors: Mihai Dorin Vartolomei, Daniel Porav-Hodade, Matteo Ferro, Romain Mathieu, Mohammad Abufaraj, Beat Foerster, Shoji Kimura, Shahrokh F. Shariat Tags: Review Article Source Type: research

Commentary on “Prognostic effect of carcinoma in situ in muscle-invasive urothelial carcinoma patients receiving neoadjuvant chemotherapy.”
Carcinoma in situ (CIS) is a poor prognostic finding in urothelial carcinoma. However, its significance in muscle-invasive urothelial carcinoma (MIUC) treated with neoadjuvant chemotherapy (NAC) is uncertain. We assessed the effect of CIS found in pretreatment transurethral resection of bladder tumor (TURBT) biopsies on the pathologic and clinical outcomes. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 4, 2018 Category: Urology & Nephrology Authors: DE Thomas, HZ Kaimakliotis, KR Rice, JA Pereira, P Johnston, ML Moore, A Reed, DM Cregar, C Franklin, RL Loman, MO Koch, R Bihrle, RS Foster, TA Masterson, TA Gardner, CP Sundaram, CR Powell, SDW Beck, DJ Grignon, L Cheng, C Albany, NM. Hahn Tags: Urologic Oncology Survey Source Type: research

Contemporary outcomes of palliative transurethral resection of the prostate in patients with locally advanced prostate cancer
Advanced prostate cancer may cause significant local complications which affect quality of life, including bladder outlet obstruction and hematuria. We performed a detailed review of our outcomes of palliative transurethral resection of the prostate (pTURP) in the era of taxane chemotherapy and potent androgen receptor antagonists at our tertiary-care institution. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 4, 2018 Category: Urology & Nephrology Authors: Joanie Pelletier, Sarah-Jeanne Cyr, Anne-Sophie Julien, Yves Fradet, Louis Lacombe, Paul Toren Tags: Original article Source Type: research

Metric substage according to micro and extensive lamina propria invasion improves prognostics in T1 bladder cancer
Reliable prognosticators for T1 bladder cancer (T1BC) are urgently needed. Objective: To compare the prognostic value of 2 substage systems for T1BC in patients treated by transurethral resection (TUR) and adjuvant bacillus Calmette-Gu érin therapy. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 4, 2018 Category: Urology & Nephrology Authors: Elisabeth E. Fransen van de Putte, Wolfgang Otto, Arndt Hartmann, Simone Bertz, Roman Mayr, Johannes Br ündl, Johannes Breyer, Quentin Manach, Eva M. Compérat, Joost L. Boormans, Judith Bosschieter, Michael A.S. Jewett, Robert Stoehr, Geert J.L.H. van L Tags: Original article Source Type: research

External validation of Chun, PCPT, ERSPC, Kawakami, and Karakiewicz nomograms in the prediction of prostate cancer: A single center cohort-study
The aim of our study was to analyze the performance of 5 different risk calculators for prostate cancer diagnosis: Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC), European Randomized Study of Screening for Prostate Cancer Risk Calculator (ERSP-RC), Karakiewicz nomogram, Chun nomogram, and Kawakami Nomogram. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 4, 2018 Category: Urology & Nephrology Authors: Cosimo De Nunzio, Riccardo Lombardo, Giorgia Tema, Hassan Alkhatatbeh, Giorgio Gandaglia, Alberto Briganti, Andrea Tubaro Tags: Original article Source Type: research

Commentary on “Detection and oncological effect of circulating tumor cells in patients with variant urothelial carcinoma histology treated with radical cystectomy.”
To investigate for the presence of circulating tumor cells (CTC) in patients with variant urothelial carcinoma of the bladder (UCB) histology treated with radical cystectomy (RC), and to determine their impact on oncological outcomes. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 4, 2018 Category: Urology & Nephrology Authors: A Soave, S Riethdorf, R Dahlem, S Minner, L Weisbach, O Engel, M Fisch, K Pantel, M. Rink Tags: Urologic Oncology Survey Source Type: research

Declining incidence of benign lesions among small renal masses treated with surgery: Effect of diagnostic tests for characterization
We evaluated the changes in the incidence of benign lesions in surgically removed small renal masses (SRMs) and the effect of diagnostic tests for characterizing SRMs. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - June 1, 2018 Category: Urology & Nephrology Authors: Sangjun Yoo, Dalsan You, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn, In Gab Jeong Tags: Original article Source Type: research

Blue light cystoscopy for the diagnosis of bladder cancer: Results from the US prospective multicenter registry
Blue light cystoscopy (BLC) using hexaminolevulinate (HAL/Cysview/Hexvix) has been previously shown to improve detection of non –muscle-invasive bladder cancer (NMIBC). Herein, we evaluated the detection of malignant lesions in a heterogenous group of patients in the real world setting and documented the change in risk category due to upstaging or upgrading. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - May 30, 2018 Category: Urology & Nephrology Authors: Siamak Daneshmand, Soroush T. Bazargani, Trinity J. Bivalacqua, Jeffrey M. Holzbeierlein, Brian Willard, Jennifer M. Taylor, Joseph C. Liao, Kamal Pohar, James Tierney, Badrinath Konety, Blue Light Cystoscopy with Cysview Registry Group Tags: Original article Source Type: research