FGF-2 is a driving force for chromosomal instability and a stromal factor associated with adverse clinico-pathological features in prostate cancer

There is mounting evidence to suggest that stromal cells play an integral role in the progression of prostate cancer (PCa). One of the most frequently altered growth factors in PCa is fibroblast growth factor-2 (FGF-2). It has previously been proposed that early stages of PCa are characterized by a primarily exogenous, that is, stromal cell-derived FGF-2 production, whereas advanced tumors rely more on an autocrine FGF-2 production. Prostate cancer progression is characterized by an increase of genomic instability including aneuploidy and structural chromosomal alterations.

Source: Urologic Oncology: Seminars and Original Investigations - June 7, 2018 Category: Urology & Nephrology Authors: Carine Pecqueux, Aysenur Arslan, Martina Heller, Michael Falkenstein, Adam Kaczorowski, Yanis Tolstov, Holger S ültmann, Carsten Grüllich, Esther Herpel, Anette Duensing, Glen Kristiansen, Markus Hohenfellner, Nora M. Navone, Stefan Duensing Tags: Original article Source Type: research