Urologic Oncology: Seminars and Original Investigations This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Metabolic changes in bladder cancer
Bladder cancer is a common solid tumor. Outcomes are poor in advanced disease, with few novel clinical therapeutics introduced over the previous several decades. Otto Warburg's original hypothesis that cancer cells use aerobic glycolysis to produce ATP instead of traditional oxidative phosphorylation in the mitochondria was a landmark discovery in its time. Recent studies indicate metabolic changes in cancer are far more complex than originally anticipated though. The purpose of this review is to understand metabolic changes that occur in bladder cancer, how targeting these changes could potentially be used therapeutically...
Source: Urologic Oncology: Seminars and Original Investigations - May 14, 2018 Category: Urology & Nephrology Authors: Benjamin L. Woolbright, Matthew Ayres, John A. Taylor Tags: Review Article Source Type: research

Predicting morbidity after robotic partial nephrectomy: The effect of tumor, environment, and patient-related factors
To investigate the effect of tumor and nontumor related parameters on perioperative outcomes of robotic partial nephrectomy (RPN). (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - May 11, 2018 Category: Urology & Nephrology Authors: Zine ‐Eddine Khene, Benoit Peyronnet, Neil J. Kocher, Haley Robyak, Corentin Robert, Benjamin Pradere, Emmanuel Oger, Solène-Florence Kammerer-Jacquet, Grégory Verhoest, Nathalie Rioux-Leclercq, Romain Mathieu, Jay D. Raman, Karim Bensalah Tags: Original article Source Type: research

Decision analysis defining optimal management of clinical stage 1 high-risk nonseminomatous germ cell testicular cancer with lymphovascular invasion
Risk of recurrent disease for men with clinical stage 1 high-risk nonseminomatous germ cell testicular cancer (CS1 NSGCT) with lymphovascular invasion (LVI) after orchiectomy is 50% and current treatment options (surveillance [S], retroperitoneal lymph node dissection [RPLND], or 1 cycle of BEP [BEP ×1]) are associated with a 99% disease specific survival, therefore practice patterns vary. We performed a decision analysis using updated data of long-term complications for men with CS1 NSGCT with LVI to quantify and assess relative treatment values. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - May 10, 2018 Category: Urology & Nephrology Authors: Svetlana Avulova, Clayton Allen, Alicia Morgans, Kelvin A. Moses Tags: Original article Source Type: research

Fusion prostate biopsy outperforms 12-core systematic prostate biopsy in patients with prior negative systematic biopsy: A multi-institutional analysis
Patients with persistently elevated prostate specific antigen (PSA) and prior negative 12-core TRUS prostate biopsy (or biopsies) (systematic biopsy —SBx) are a diagnostic challenge. Repeat SBx or saturation biopsy in this cohort has been shown to have an even lower yield. The aim of our study is to compare the prostate cancer yield of magnetic resonance imaging (MRI) fusion biopsy (FBx) to SBx in a multi-institutional cohort comprised of pati ents with prior negative biopsies. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - May 9, 2018 Category: Urology & Nephrology Authors: Abhinav Sidana, Matthew J. Watson, Arvin K. George, Ardeshir R. Rastinehad, Srinivas Vourganti, Soroush Rais-Bahrami, Akhil Muthigi, Mahir Maruf, Jennifer B. Gordetsky, Jeffrey W. Nix, Maria J. Merino, Baris Turkbey, Peter L. Choyke, Bradford J. Wood, Pet Tags: Original article Source Type: research

Multi-institutional evaluation of the prognostic significance of EZH2 expression in high-grade upper tract urothelial carcinoma
Enhancer of zeste homolog 2 is a methyltransferase encoded by the EZH2 gene, whose role in upper tract urothelial carcinoma (UTUC) is poorly understood. We sought to evaluate the prognostic value of EZH2 expression in UTUC. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - May 7, 2018 Category: Urology & Nephrology Authors: Nirmish Singla, Laura-Maria Krabbe, Ahmet M. Aydin, Vandana Panwar, Solomon L. Woldu, Yuval Freifeld, Christopher G. Wood, Jose A. Karam, Alon Z. Weizer, Jay D. Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Marco Roscigno, Christian Bolenz, Tags: Original article Source Type: research

Finasteride does not prevent bladder cancer: A secondary analysis of the Medical Therapy for Prostatic Symptoms Study
This study aims to evaluate whether dihydrotestosterone-mediated androgen activity has an impact on BC incidence in a cohort of men included in a clinical trial of finasteride vs. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - May 3, 2018 Category: Urology & Nephrology Authors: Niranjan J. Sathianathen, Yunhua Fan, Stephanie L. Jarosek, Nathan L. Lawrentschuk, Badrinath R. Konety Tags: Original article Source Type: research

Establishment of the optimal follow-up schedule after radical prostatectomy
Monitoring the serum level of prostate specific antigen (PSA) is indispensable for surveillance after radical therapy, and the aim of this study was to establish the optimal follow-up schedule. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - May 2, 2018 Category: Urology & Nephrology Authors: Kazuhiro Matsumoto, Naoya Niwa, Seiya Hattori, Toshikazu Takeda, Shinya Morita, Takeo Kosaka, Ryuichi Mizuno, Toshiaki Shinojima, Eiji Kikuchi, Hiroshi Asanuma, Mototsugu Oya Tags: Original article Source Type: research

Cover 2 -- Masthead
(Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - May 1, 2018 Category: Urology & Nephrology Source Type: research

Editorial Board
(Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - May 1, 2018 Category: Urology & Nephrology Source Type: research

Table of Contents
(Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - May 1, 2018 Category: Urology & Nephrology Source Type: research

Physician visits and the timing of skeletal-related events among men newly diagnosed with metastatic prostate cancer: A cohort analysis
Men diagnosed with metastatic prostate cancer (PCa) are at increased risk for skeletal complications which are associated with significant morbidity and mortality. Although both the urologist and the medical oncologist play important roles in the management of patients with advanced PCa, there is limited information regarding their role in the context of skeletal complications. The current study investigated these relationships among newly diagnosed metastatic patients with PCa. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - April 30, 2018 Category: Urology & Nephrology Authors: Eberechukwu Onukwugha, Husam Albarmawi, Kai Sun, C. Daniel Mullins, Abdalla Aly, Arif Hussain Tags: Original article Source Type: research

Psychological and functional effect of different primary treatments for prostate cancer: A comparative prospective analysis
The aim of the study was to comparatively evaluate the psychological and functional effect of different primary treatments in patients with prostate cancer. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - April 26, 2018 Category: Urology & Nephrology Authors: Alessandro Sciarra, Alessandro Gentilucci, Stefano Salciccia, Magnus Von Heland, Giam Piero Ricciuti, Vittorio Marzio, Federico Pierella, Daniela Musio, Vincenzo Tombolini, Viviana Frantellizzi, Massimo Pasquini, Annalisa Maraone, Alessio Guandalini, Mart Tags: Original article Source Type: research

Detection of urothelial carcinoma, upper tract urothelial carcinoma, bladder carcinoma, and urothelial carcinoma with gross hematuria using selected urine-DNA methylation biomarkers: A prospective, single-center study
Hematuria is the most common symptom of urothelial carcinomas (UC) but is often idiopathic. Cystoscopy is expensive which involves considerable patient discomfort, and conventional urine cytology for noninvasive UC detection and disease monitoring suffers from poor sensitivity. We aim to evaluate the performance of genes selected from a previous study in detecting UC, especially among patients with gross hematuria, as well as upper tract urothelial carcinoma (UTUC) and bladder carcinoma separately, in voided urine samples. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - April 26, 2018 Category: Urology & Nephrology Authors: Run-Qi Guo, Geng-Yan Xiong, Kai-Wei Yang, Lei Zhang, Shi-Ming He, Yan-Qing Gong, Qun He, Xue-Ying Li, Zi-Cheng Wang, Zhen-Qing Bao, Xue-Song Li, Kai Zhang, Li-Qun Zhou Tags: Original article Source Type: research

Lifestyle and nutritional modifiable factors in the prevention and treatment of bladder cancer
Bladder cancer is one of the top 5 most common cancers diagnosed in the U.S. It is also one of the most expensive cancers to treat through the life course given its high rate of recurrence. While cigarette smoking and occupational exposures have been firmly established as risk factors, it is less certain whether modifiable lifestyle factors such as diet and physical activity play roles in bladder cancer etiology and prognosis. This literature review based on a PubMed search summarizes the research to date on key dietary factors, types of physical activity, and smoking in relation to bladder cancer incidence, and discusses ...
Source: Urologic Oncology: Seminars and Original Investigations - April 24, 2018 Category: Urology & Nephrology Authors: Marilyn L. Kwan, Brandon Garren, Matthew E. Nielsen, Li Tang Tags: Seminars Article Source Type: research