Urologic Oncology: Seminars and Original Investigations This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Immunohistochemical expression of Ki-67, Cyclin D1, p16INK4a, and Survivin as a predictive tool for recurrence and progression-free survival in papillary urothelial bladder cancer pTa / pT1 G2 (WHO 1973)
The incidence of urothelial bladder cancer (UBC) has increased during the last decades; in western countries, it is the fourth most common tumor type, after prostate, lung, and colorectal cancer [1]. UBC has a worldwide incidence of 294,345, and 88,315 cases per year in men and women (European prevalence of 112,819, and 30,736 cases, respectively). (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Jos é Antonio March-Villalba, David Ramos-Soler, Pilar Soriano-Sarrió, David Hervás-Marín, Laura Martínez-García, José María Martínez-Jabaloyas Tags: Original Article Source Type: research

Management of bone and metabolic effects of androgen deprivation therapy
Androgen Deprivation Therapy (ADT) has established roles in the neoadjuvant treatment of high risk localized prostate cancer (CaP) together with radiotherapy, and in biochemically recurrent nonmetastatic, and metastatic disease. Use of gonadotrophin-releasing hormone (GnRH) analogs as a means of blocking testosterone production is currently the most commonly used ADT modality. As long-term survival in men receiving ADT is the norm, it is appropriate to focus on identification and mitigation of adverse effects of this therapy. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Nicholas Russell, Mathis Grossmann Tags: Seminars Article Source Type: research

Exercise medicine for the management of androgen deprivation therapy-related side effects in prostate cancer
Androgen deprivation therapy (ADT) is associated with considerable adverse side effects which compromise the health and wellbeing of many men with prostate cancer. Exercise has been identified as a therapy to help manage ADT-related treatment toxicities. This paper systematically reviews the scientific literature investigating the impact of exercise on men receiving ADT and discusses strategies to effectively implement exercise in clinical practice. The findings of this review demonstrate that exercise has therapeutic benefit for the management of ADT-related side effects. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Prue Cormie, Eva M Zopf Tags: Seminars Article Source Type: research

Optimal sampling scheme in men with abnormal multiparametric MRI undergoing MRI-TRUS fusion prostate biopsy
Prostate cancer is the most common cancer in men with an estimated incidence of over 164,000 new cases in 2018 in the United States [1]. As multiparametric magnetic resonance imaging (mpMRI) is becoming more available, the use of MRI-transrectal ultrasound (TRUS) fusion targeted prostate biopsy (TBx) is rising and has the potential of becoming the new standard of care [2]. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Yuval Freifeld, Yin Xi, Niccolo Passoni, Solomon Woldu, Brad Hornberger, Kenneth Goldberg, Aditya Bagrodia, Ganesh Raj, Vitaly Margulis, Jeffrey A. Cadeddu, Yair Lotan, Franto Francis, Ivan Pedrosa, Claus G. Roehrborn, Daniel N. Costa Tags: Original article Source Type: research

The requirement for immune infiltration and organization in the tumor microenvironment for successful immunotherapy in prostate cancer
Immunotherapy —particularly immune checkpoint blockade—has seen great success in many tumor types. However, checkpoint-based therapies have not demonstrated high levels of success in prostate cancer, and there is much to be learned from both the successes and failures of these treatments. Here we review the e vidence that composition of infiltrating immune cells in the tumor microenvironment is fundamental the response to immunotherapy. Additionally, we discuss the emerging idea that the organization of these immune cells may also be crucial to this response. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Caroline S. Jansen, Nataliya Prokhnevska, Haydn T. Kissick Tags: Seminars Article Source Type: research

Implications of micropapillary urothelial carcinoma variant on prognosis following radical cystectomy: A multi-institutional investigation
To determine the association of micropapillary urothelial carcinoma (MUC) variant histology with bladder cancer outcomes after radical cystectomy. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Anirban P. Mitra, Adrian S. Fairey, Eila C. Skinner, Stephen A. Boorjian, Igor Frank, Mark P. Schoenberg, Trinity J. Bivalacqua, M. Eric Hyndman, Adam C. Reese, Gary D. Steinberg, Michael C. Large, Christina A. Hulsbergen-van de Kaa, Harman M. Bruins, Sia Tags: Original Article Source Type: research

Tumor expression of miR-34a-3p is an independent predictor of recurrence in non –muscle-invasive bladder cancer and promising additional factor to improve predictive value of EORTC nomogram
Non –muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease characterized by a high primary tumor recurrence rate. Current prognostic systems used for predicting recurrence in individual patients have limitations and do not consider the biological background of this tumor type. Our study ai med to find microRNAs (miRNAs) associated with NMIBC recurrence. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Jaroslav Juracek, Michal Stanik, Petra Vesela, Lenka Radova, Jan Dolezel, Marek Svoboda, Ondrej Slaby Tags: Original article Source Type: research

Mutational landscape of non-muscle-invasive bladder cancer
Non-muscle-invasive bladder cancer (NMIBC) includes stage Ta and stage T1 tumors and carcinoma in situ (CIS). Grading of Ta tumors subdivides these lesions into papillary urothelial neoplasms of low malignant potential and low- and high-grade noninvasive papillary urothelial carcinoma. CIS is by definition high-grade and the majority of stage T1 tumors are of high-grade. This pathologic heterogeneity is associated with divergent clinical outcome, with significantly worse prognosis for patients with T1 tumors or CIS. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Carolyn D. Hurst, Margaret A. Knowles Tags: Seminars article Source Type: research

Loss of BAP1 expression in metastatic tumor tissue is an event of poor prognosis in patients with metastatic clear cell renal cell carcinoma
To evaluate the prognostic impact of the protein expression of both PBRM1 and BAP1 in metastatic tissue of patients with metastatic clear cell renal cell carcinoma (ccRCC). (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Walter Henriques da Costa, Aline Fusco Fares, Stephania M. Bezerra, Mariana A Morini, Ligia Alencar de Toledo Benigno, Diego Abreu Clavijo, Lucas Fornazieri, Maur ício Murce Rocha, Isabela Werneck da Cunha, Stenio de Cassio Zequi Tags: Original Article Source Type: research

Variation in surgical treatment patterns for patients with prostate cancer in the United States: Do patients in academic hospitals fare better?
With prostate cancer (CaP) screening, overtreatment of low-risk CaP remains a concern. We investigated the patterns of radical prostatectomy (RP) for pathologic insignificant (iCaP) and significant CaP (sCaP) as well as variations between academic and nonacademic hospitals. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Aydin Pooli, Amirali Salmasi, Izak Faiena, Andrew T. Lenis, David C. Johnson, Cedric Lebacle, Alexandra Drakaki, Kiran Gollapudi, Jeremy Blumberg, Allan J. Pantuck, Karim Chamie Tags: Original Article Source Type: research

Serum testosterone level as possible predictive marker in androgen receptor axis-targeting agents and taxane chemotherapies for castration-resistant prostate cancer
Currently, several therapeutic options for castration-resistant prostate cancer (CRPC) are available, for which predictive biomarkers have not been established. Therefore, we aimed to reveal the association between pretreatment serum testosterone level and antitumor outcomes when treated with androgen receptor axis-targeting agents and taxane chemotherapies for CRPC. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Masaki Shiota, Eiji Kashiwagi, Tomohiko Murakami, Ario Takeuchi, Kenjiro Imada, Junichi Inokuchi, Katsunori Tatsugami, Masatoshi Eto Tags: Original Article Source Type: research

Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A expression ratios in urinary cell-free DNA for discriminating bladder cancer from hematuria
In this study, we compared ucfDNA gene expression levels between patients with bladder cancer (BC) and those with hematuria, and determined whether they could be used as a noninvasive urine-based marker. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Yanjie Xu, Ye-Hwan Kim, Pildu Jeong, Xuan-Mei Piao, Young Joon Byun, Ho Won Kang, Won Tae Kim, Jong-Young Lee, Isaac Y. Kim, Sung-Kwon Moon, Yung Hyun Choi, Seok Joong Yun, Wun-Jae Kim Tags: Original Article Source Type: research

Hospital length of stay following radical cystectomy for muscle-invasive bladder cancer: Development and validation of a population-based prediction model
Length of hospital stay for patients following radical cystectomy is an important determinant for improved quality of care. We sought to develop and validate a predictive model for length of hospital stay following radical cystectomy. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 13, 2018 Category: Urology & Nephrology Authors: Mohamed D. Ray-Zack, Yong Shan, Hemalkumar B. Mehta, Xiaoying Yu, Ashish M. Kamat, Stephen B. Williams Tags: Original article Source Type: research

Radical prostatectomy after previous TUR-P: Oncological, surgical, and functional outcomes
To examine oncological, surgical, and functional outcomes of radical prostatectomy (RP) in patients with history of transurethral resection of the prostate (TUR-P). (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - November 12, 2018 Category: Urology & Nephrology Authors: Raisa S. Pompe, Sami-Ramzi Leyh-Bannurah, Felix Preisser, Georg Salomon, Markus Graefen, Hartwig Huland, Pierre I. Karakiewicz, Derya Tilki Tags: Original article Source Type: research

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(Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - October 30, 2018 Category: Urology & Nephrology Source Type: research