Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1

We recently determined that a novel oncogene, IPO11 from 5q12, participates in bladder cancer (BCa) progression. However, the biological function of IPO11 and the molecular mechanisms through which it contributes to BCa progression remain unclear. The aim of this study was to investigate the role of IPO11 in BCa aggressiveness and elucidate the molecular mechanisms underlying its effects in BCa.

Source: Urologic Oncology: Seminars and Original Investigations - March 27, 2018 Category: Urology & Nephrology Authors: Junjie Zhao, Lei Shi, Shuxiong Zeng, Chong Ma, Weidong Xu, Zhensheng Zhang, Qingzuo Liu, Peng Zhang, Yinghao Sun, Chuanliang Xu Tags: Original article Source Type: research