Corrigendum
(Source: The Prostate)
Source: The Prostate - December 26, 2017 Category: Urology & Nephrology Authors: Thierry Muanza Tags: CORRIGENDUM Source Type: research
Prostate tumors downregulate microseminoprotein ‐beta (MSMB) in the surrounding benign prostate epithelium and this response is associated with tumor aggressiveness
ConclusionOur data suggest that aggressive prostate tumors suppress MSMB synthesis in the benign prostate and that this could explain why serum levels of MSMB are decreased in prostate cancer patients. This study suggests that markers for aggressive cancer can be found among factors altered in parallel in prostate tumors and in the adjacent benign tissue. (Source: The Prostate)
Source: The Prostate - December 18, 2017 Category: Urology & Nephrology Authors: Sofia Halin Bergstr öm, Helena Järemo, Maria Nilsson, Hanibal Hani Adamo, Anders Bergh Tags: ORIGINAL ARTICLE Source Type: research
Validation of histone deacetylase 3 as a therapeutic target in castration ‐resistant prostate cancer
ConclusionsOur studies provide strong rationale for the near‐term development of specific HDAC3 inhibitors for the treatment of CRPC. (Source: The Prostate)
Source: The Prostate - December 15, 2017 Category: Urology & Nephrology Authors: Abigail B. McLeod, James P. Stice, Suzanne E. Wardell, Holly M. Alley, Ching ‐yi Chang, Donald P. McDonnell Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: The Prostate)
Source: The Prostate - December 12, 2017 Category: Urology & Nephrology Tags: ISSUE INFORMATION Source Type: research
Candidate diagnostic miRNAs that can detect cancer in prostate biopsy
ConclusionsOur sequencing analyses identified several candidate diagnostic miRNAs and confirmed some which have previously been reported as diagnostic in prostate malignancy. The results of this study suggest also that some of selected miRNAs can differentiate between non‐malignant and malignant prostates even when neoplastic cells are missing from the studied specimen. (Source: The Prostate)
Source: The Prostate - December 11, 2017 Category: Urology & Nephrology Authors: Agnieszka Paziewska, Michal Mikula, Michalina Dabrowska, Maria Kulecka, Krzysztof Goryca, Artur Antoniewicz, Jakub Dobruch, Andrzej Borowka, Piotr Rutkowski, Jerzy Ostrowski Tags: ORIGINAL ARTICLE Source Type: research
Issue Information ‐ Editorial Board
(Source: The Prostate)
Source: The Prostate - December 4, 2017 Category: Urology & Nephrology Tags: Issue Information Source Type: research
Serum ‐free complete medium, an alternative medium to mimic androgen deprivation in human prostate cancer cell line models
ConclusionsMedia composition contributed to growth differences observed between CaP cells cultured in SFM or CSM. However, the differences in media composition did not impair CaP cell response to T‐stimulated growth, bicalutamide growth inhibition, metabolism of T, or dutasteride efficiency. SFM can be used as a better defined alternative to CSM for androgen deprivation experiments. (Source: The Prostate)
Source: The Prostate - December 1, 2017 Category: Urology & Nephrology Authors: Michael V. Fiandalo, John H. Wilton, Krystin M. Mantione, Carol Wrzosek, Kristopher M. Attwood, Yue Wu, James L. Mohler Tags: ORIGINAL ARTICLE Source Type: research
Mediterranean diet after prostate cancer diagnosis and urinary and sexual functioning: The health professionals follow ‐up study
ConclusionsAmong men with prostate cancer, diet intake after diagnosis was not significantly associated with urinary or sexual function, although some relationships appeared to differ among men with and without symptoms prior to their prostate cancer diagnosis. Higher vegetable intake and lower polyunsaturated fat intake after prostate cancer diagnosis may be associated with better urinary function. However, this analysis was exploratory, and further research is needed to better delineate these relationships and guide dietary recommendations for men with prostate cancer. (Source: The Prostate)
Source: The Prostate - December 1, 2017 Category: Urology & Nephrology Authors: Scott R. Bauer, Erin L. Van Blarigan, Meir J. Stampfer, June M. Chan, Stacey A. Kenfield Tags: ORIGINAL ARTICLE Source Type: research
A carbon 21 steroidal metabolite from progestin, 20 β‐hydroxy‐5α‐dihydroprogesterone, stimulates the androgen receptor in prostate cancer cells
ConclusionsUnder ADT, 20β‐OHDHP synthesized intracellularly from accumulated progestin in PC cells may accelerate cell growth via stimulation of both wAR and mAR. This pathway may represent an interesting candidate for targeted therapy. (Source: The Prostate)
Source: The Prostate - December 1, 2017 Category: Urology & Nephrology Authors: Takashi Ando, Tsutomu Nishiyama, Itsuhiro Takizawa, Yoshimichi Miyashiro, Noboru Hara, Yoshihiko Tomita Tags: ORIGINAL ARTICLE Source Type: research
GOLM1 promotes prostate cancer progression through activating PI3K ‐AKT‐mTOR signaling
ConclusionGOLM1 acts as a critical oncogene by promoting PCa cell proliferation, migration and invasion, and inhibiting apoptosis. GOLM1 plays oncogenic functions mainly through activating PI3K‐AKT‐mTOR signaling pathway. Therefore, agents that block PI3K‐AKT‐mTOR signaling pathway could be used in PCa patients with GOLM1 up‐regulation. (Source: The Prostate)
Source: The Prostate - November 28, 2017 Category: Urology & Nephrology Authors: Guang Yan, Yi Ru, Kerong Wu, Fengqi Yan, Qinhao Wang, Jingxiang Wang, Tao Pan, Mei Zhang, Hua Han, Xia Li, Lian Zou Tags: REVIEW ARTICLE Source Type: research
Genetic factors influencing prostate cancer risk in Norwegian men
Norway has one of the highest rates of death due to prostate cancer (PCa) in the world. To assess the contribution of both common and rare single nucleotide variants (SNPs) to the prostate cancer burden in Norway, we assessed the frequency of the established prostate cancer susceptibility allele, HOXB13 G84E, as well as a series of validated, common PCa risk SNPs in a Norwegian PCa population of 779 patients. The G84E allele was observed in 2.3% of patients compared to 0.7% of control individuals, OR = 3.8, P = 1 × 10‐4. While there was a trend toward an earlier age at diagnosis, overall the clinicopathologi...
Source: The Prostate - November 27, 2017 Category: Urology & Nephrology Authors: Haitao Chen, Charles M. Ewing, Sigun Zheng, Eli M. Grindedaal, Kathleen A. Cooney, Kathleen Wiley, Srdjan Djurovic, Ole A. Andreassen, Karol Axcrona, Ian G. Mills, Jianfeng Xu, Lovise Maehle, Sophie D. Foss å, William B. Isaacs Tags: ORIGINAL ARTICLE Source Type: research
TRAF6 regulates proliferation of stromal cells in the transition and peripheral zones of benign prostatic hyperplasia via Akt/mTOR signaling
ConclusionsTRAF6 can promote the proliferation of stromal cells of BPH via Akt/mTOR signaling. Our results may make stromal TRAF6 responsible for zonal characteristic of BPH and as a promising therapeutic strategy for BPH treatment. (Source: The Prostate)
Source: The Prostate - November 24, 2017 Category: Urology & Nephrology Authors: Yun ‐Feng Shi, Dian‐Jun Yu, Chen‐Yi Jiang, Xing‐Jie Wang, Yi‐Ping Zhu, Rui‐Zhe Zhao, Zhong Lv, Xiao‐Wen Sun Tags: ORIGINAL ARTICLE Source Type: research
Capillarisin blocks prostate ‐specific antigen expression on activation of androgen receptor in prostate carcinoma cells
ConclusionsOur results indicated that Cap inhibited growth of LNCaP cells. Cap effectively suppressed androgen activation on AR‐mediated transactivation, which is AR‐dependent through AR degradation and dissociation of AR‐Hsp90 in prostate carcinoma cells. (Source: The Prostate)
Source: The Prostate - November 22, 2017 Category: Urology & Nephrology Authors: Ke ‐Hung Tsui, Ying‐Ling Chang, Tsui‐Hsia Feng, Chen‐Pang Hou, Yu‐Hsiang Lin, Pei‐Shan Yang, Bing‐Wei Lee, Horng‐Heng Juang Tags: ORIGINAL ARTICLE Source Type: research
Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells
ConclusionTelomere variability in prostate cells may be one mechanism through which smoking influences poor prostate cancer outcomes. (Source: The Prostate)
Source: The Prostate - November 22, 2017 Category: Urology & Nephrology Authors: Corinne E. Joshu, Sarah B Peskoe, Christopher M. Heaphy, Stacey A. Kenfield, Lorelei A. Mucci, Edward L. Giovannucci, Meir J. Stampfer, Ghilsuk Yoon, Thomas K. Lee, Jessica L. Hicks, Angelo M. De Marzo, Alan K. Meeker, Elizabeth A. Platz Tags: ORIGINAL ARTICLE Source Type: research
Long ‐term oral exposure to safe dose of bisphenol A in association with high‐fat diet stimulate the prostatic lesions in a rodent model for prostate cancer
ConclusionsThe results indicated that the methodology used was effective in generating metabolic changes, which directly compromised prostatic homeostasis. Diet and BPA appear to modulate the activation of the AR pathway and thereby optimize tumor establishment in the gerbil prostate. (Source: The Prostate)
Source: The Prostate - November 17, 2017 Category: Urology & Nephrology Authors: Camila H. Facina, Silvana G.P. Campos, Bianca F. Gon çalves, Rejane M. Góes, Patricia S.L. Vilamaior, Sebastião R. Taboga Tags: ORIGINAL ARTICLE Source Type: research
