Osteoblast ‐derived factors promote metastatic potential in human prostate cancer cells, in part via non‐canonical transforming growth factor β (TGFβ) signaling
The Prostate,Volume 78, Issue 6, Page 446-456, May 1, 2018. (Source: The Prostate)
Source: The Prostate - January 31, 2018 Category: Urology & Nephrology Source Type: research
Metastatic prostate cancer ‐associated P62 inhibits autophagy flux and promotes epithelial to mesenchymal transition by sustaining the level of HDAC6
The Prostate,Volume 78, Issue 6, Page 426-434, May 1, 2018. (Source: The Prostate)
Source: The Prostate - January 31, 2018 Category: Urology & Nephrology Source Type: research
Circulating microRNAs in plasma as potential biomarkers for the early detection of prostate cancer
The Prostate,Volume 78, Issue 6, Page 411-418, May 1, 2018. (Source: The Prostate)
Source: The Prostate - January 31, 2018 Category: Urology & Nephrology Source Type: research
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The Prostate,Volume 78, Issue 6, Page 446-456, May 1, 2018. (Source: The Prostate)
Source: The Prostate - January 31, 2018 Category: Urology & Nephrology Source Type: research
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The Prostate,Volume 78, Issue 6, Page 426-434, May 1, 2018. (Source: The Prostate)
Source: The Prostate - January 31, 2018 Category: Urology & Nephrology Source Type: research
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The Prostate,Volume 78, Issue 6, Page 411-418, May 1, 2018. (Source: The Prostate)
Source: The Prostate - January 31, 2018 Category: Urology & Nephrology Source Type: research
Metastatic prostate cancer ‐associated P62 inhibits autophagy flux and promotes epithelial to mesenchymal transition by sustaining the level of HDAC6
ConclusionP62 promotes metastasis of PCA by sustaining the level of P62 to inhibit autophagy and promote epithelial‐to‐mesenchymal transition. (Source: The Prostate)
Source: The Prostate - January 31, 2018 Category: Urology & Nephrology Authors: Xianhan Jiang, Yiqiao Huang, Xue Liang, Funeng Jiang, Yongzhong He, Tian Li, Guibin Xu, Haibo Zhao, Weiqing Yang, Ganggang Jiang, Zhengming Su, Lingke Jiang, Leyuan Liu Tags: ORIGINAL ARTICLE Source Type: research
Circulating microRNAs in plasma as potential biomarkers for the early detection of prostate cancer
ConclusionsThere was no miRNA associated with PC diagnosis after adjusting for age and P‐values; however, moderate correlations between miRNAs and serum PSA were observed. Further investigation between miRNAs and PC risk is warranted in a larger population at high risk for PC. (Source: The Prostate)
Source: The Prostate - January 31, 2018 Category: Urology & Nephrology Authors: Alicia C. McDonald, Manish Vira, Jing Shen, Martin Sanda, Jay D. Raman, Jason Liao, Dattatraya Patil, Emanuela Taioli Tags: ORIGINAL ARTICLE Source Type: research
Accuracy of standardized 12 ‐core template biopsies versus non‐standardized biopsies for detection of Epstein Grade 5 prostate cancer regarding the histology of the prostatectomy specimen
ConclusionDetection rates of highly aggressive Epstein Grade 5 prostate cancer vary considerably according to the biopsy technique. EAU Guideline compliant 12‐core template biopsies increase the detection rates of Epstein Grade 5 prostate cancer. (Source: The Prostate)
Source: The Prostate - January 25, 2018 Category: Urology & Nephrology Authors: Christoph W ürnschimmel, Pietro Grande, Marco Moschini, Matteo Ferrari, Livio Mordasini, Agostino Mattei Tags: ORIGINAL ARTICLE Source Type: research
Anatomical localization and clinical impact of sentinel lymph nodes based on patterns of pelvic lymphatic drainage in clinically localized prostate cancer
The Prostate,Volume 78, Issue 6, Page 419-425, May 1, 2018. (Source: The Prostate)
Source: The Prostate - January 25, 2018 Category: Urology & Nephrology Source Type: research
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The Prostate,Volume 78, Issue 6, Page 419-425, May 1, 2018. (Source: The Prostate)
Source: The Prostate - January 25, 2018 Category: Urology & Nephrology Source Type: research
Anatomical localization and clinical impact of sentinel lymph nodes based on patterns of pelvic lymphatic drainage in clinically localized prostate cancer
ConclusionsOver 90% of positive sentinel lymph nodes were identified at two predominant sites. Priority should be given to the removal of these sentinel lymph nodes, which are located closer to the prostate, in pelvic lymph node dissection. Particular attention should be paid to identifying these nodes to reduce the possibility of overlooking lymph node metastasis. (Source: The Prostate)
Source: The Prostate - January 25, 2018 Category: Urology & Nephrology Authors: Jun Miki, Takafumi Yanagisawa, Shunsuke Tsuzuki, Keiichiro Mori, Fumihiko Urabe, Sotaro Kayano, Takashi Yorozu, Shun Sato, Takahiro Kimura, Hiroyuki Takahashi, Koichi Kishimoto, Shin Egawa Tags: ORIGINAL ARTICLE Source Type: research
Intraductal/ductal histology and lymphovascular invasion are associated with germline DNA ‐repair gene mutations in prostate cancer
ConclusionsPresence of intraductal/ductal histology and lymphovascular invasion appear to be associated with pathogenic germline DNA‐repair gene mutations in men with prostate cancer, and identification of these features may help to select patients for germline testing. NCCN guidelines may be inadequate in predicting which prostate cancer patients should undergo genetic screening. (Source: The Prostate)
Source: The Prostate - January 25, 2018 Category: Urology & Nephrology Authors: Pedro Isaacsson Velho, John L. Silberstein, Mark C. Markowski, Jun Luo, Tamara L. Lotan, William B. Isaacs, Emmanuel S. Antonarakis Tags: ORIGINAL ARTICLE Source Type: research
p62 as a therapeutic target for inhibition of autophagy in prostate cancer
Conclusionsp62 has a high potential to be developed as a therapeutic target. Verteporfin represents a prototypical agent with therapeutic potential against prostate cancer through inhibition of autophagy by a novel mechanism of p62 inhibition. (Source: The Prostate)
Source: The Prostate - January 25, 2018 Category: Urology & Nephrology Authors: Lei Wang, Donghern Kim, James T.F. Wise, Xianglin Shi, Zhuo Zhang, Robert S. DiPaola Tags: ORIGINAL ARTICLE Source Type: research
Rare germline mutations in African American men diagnosed with early ‐onset prostate cancer
ConclusionsProtein‐truncating mutations in BRCA2 and BRIP1 were discovered in African American men diagnosed with early‐onset prostate cancer. Further study is necessary to determine the role of rare, missense variants to prostate cancer incidence, and progression in this group of high‐risk men. (Source: The Prostate)
Source: The Prostate - January 22, 2018 Category: Urology & Nephrology Authors: Jennifer L. Beebe ‐Dimmer, Kimberly A. Zuhlke, Anna M. Johnson, Daniel Liesman, Kathleen A. Cooney Tags: ORIGINAL ARTICLE Source Type: research
