The impact of statin use on the efficacy of abiraterone acetate in patients with castration ‐resistant prostate cancer
ConclusionsContrary to our initial hypothesis, there was a trend toward longer (rather than shorter) AA duration in statin users in the entire DFCI cohort and in the enzalutamide‐ and docetaxel‐naïve JHU patients. Together, these results do not support the hypothesis that statins interfere with AA efficacy. (Source: The Prostate)
Source: The Prostate - August 1, 2017 Category: Urology & Nephrology Authors: Lauren C. Harshman, Lillian Werner, Abhishek Tripathi, Xiaodong Wang, Benjamin L. Maughan, Emmanuel S. Antonarakis, Mari Nakabayashi, Rana McKay, Mark Pomerantz, Lorelei A. Mucci, Mary ‐Ellen Taplin, Christopher J. Sweeney, Gwo‐Shu Mary Lee, Philip W. Tags: ORIGINAL ARTICLE Source Type: research
Epigenetic risk score improves prostate cancer risk assessment
ConclusionsIn men diagnosed with PCa, DNA‐methylation profiling can detect under‐sampled high‐risk PCa in prostate biopsy specimens through a field effect. Predictive accuracy increased when EpiScore was combined with other clinical risk factors. These results suggest that EpiScore could aid in the detection of occult high‐grade disease at the time of diagnosis, thereby improving the selection of candidates for Active Surveillance. (Source: The Prostate)
Source: The Prostate - August 1, 2017 Category: Urology & Nephrology Authors: Leander Van Neste, Jack Groskopf, William E. Grizzle, George W. Adams, Mark S. DeGuenther, Peter N. Kolettis, James E. Bryant, Gary P. Kearney, Michael C. Kearney, Wim Van Criekinge, Sandra M. Gaston Tags: ORIGINAL ARTICLE Source Type: research
Immunoaffinity based methods are superior to kits for purification of prostate derived extracellular vesicles from plasma samples
ConclusionsWhile attractive due to their ease of use, EV purification kits do not provide substantial improvements in isolation of EVs from biofluids such as plasma. Immunoaffinity approaches are more efficient and economical and will also eliminate a significant portion of plasma proteins which is necessary for downstream approaches. (Source: The Prostate)
Source: The Prostate - August 1, 2017 Category: Urology & Nephrology Authors: Sabine I. Brett, Fabrice Lucien, Charles Guo, Karla C. Williams, Yohan Kim, Paul N. Durfee, C. J. Brinker, Joseph I. Chin, Jun Yang, Hon S. Leong Tags: ORIGINAL ARTICLE Source Type: research
Prognostic nutritional index predicts initial response to treatment and prognosis in metastatic castration ‐resistant prostate cancer patients treated with abiraterone
ConclusionIndependent of PSA level variation, PNI level elevation during the first month of AA treatment and high baseline PNI level were significantly correlated with initial response to AA treatment. In addition, low pretreatment PNI level is a negative independent prognosticator of survival outcomes in mCRPC treated with AA and also increases the accuracy of established prognostic model. (Source: The Prostate)
Source: The Prostate - July 28, 2017 Category: Urology & Nephrology Authors: Liancheng Fan, Xiao Wang, Chenfei Chi, Yanqing Wang, Wen Cai, Xiaoguang Shao, Fan Xu, Jiahua Pan, Yinjie Zhu, Xun Shangguan, Zhixiang Xin, Jianian Hu, Shaowei Xie, Rui Wang, Lixin Zhou, Baijun Dong, Wei Xue Tags: ORIGINAL ARTICLE Source Type: research
The impact of multifocal perineural invasion on biochemical recurrence and timing of adjuvant androgen ‐deprivation therapy in high‐risk prostate cancer following radical prostatectomy
Conclusions: Our findings suggest that detection of multi‐PNI in high‐risk RP specimens could be a prognosticator for early biochemical relapse post‐surgery. Initiation of adjuvant therapy may be appropriate in patients with multi‐PNI as soon as possible after surgery. (Source: The Prostate)
Source: The Prostate - July 28, 2017 Category: Urology & Nephrology Authors: Guangxi Sun, Rui Huang, Xingming Zhang, Pengfei Shen, Jing Gong, Jinge Zhao, Jiandong Liu, Qidun Tang, Kunpeng Shu, Xiaoxue Yin, Ni Chen, Hao Zeng Tags: ORIGINAL ARTICLE Source Type: research
A subset of high Gleason grade prostate carcinomas contain a large burden of prostate cancer syndecan ‐1 positive stromal cells
ConclusionsThe current study identifies PCSP cells as a novel, potentially migratory cell type, which is marked by Syndecan‐1 expression and is found in the stroma of prostate carcinomas, adjacent normal tissue, but not in non‐diseased prostate. A subset of poor prognosis high Gleason grade 5 tumors had a particularly high PCSP cell burden, suggesting an association between this unidentified cell type and tumor aggressiveness. (Source: The Prostate)
Source: The Prostate - July 26, 2017 Category: Urology & Nephrology Authors: Benjamin Sharpe, Dhafer A. Alghezi, Claire Cattermole, Mark Beresford, Rebecca Bowen, John Mitchard, Andrew D. Chalmers Tags: ORIGINAL ARTICLE Source Type: research
TEX15: A DNA repair gene associated with prostate cancer risk in Han Chinese
ConclusionsOur study provided preliminary evidence that the rare variant Q1631H in DNA repair gene TEX15 is associated with prostate cancer risk. This finding complements known common prostate cancer risk‐associated variants and suggests the possible role of DNA repair genes in prostate cancer development. (Source: The Prostate)
Source: The Prostate - July 21, 2017 Category: Urology & Nephrology Authors: Xiaoling Lin, Zhongzhong Chen, Peng Gao, Zhimei Gao, Haitao Chen, Jun Qi, Fang Liu, Dingwei Ye, Haowen Jiang, Rong Na, Hongjie Yu, Rong Shi, Daru Lu, Siqun Lilly Zheng, Zengnan Mo, Yinghao Sun, Qiang Ding, Jianfeng Xu Tags: ORIGINAL ARTICLE Source Type: research
Investigating the role of the IGF axis as a predictor of biochemical recurrence in prostate cancer patients post ‐surgery
ConclusionsLow PTEN is associated with BCR and this association is strongly modified by high INSR and high AKT expression. Measurement of these proteins could help inform appropriate patient selection for postoperative adjuvant therapy and prevent BCR. (Source: The Prostate)
Source: The Prostate - July 20, 2017 Category: Urology & Nephrology Authors: Kieran J. Breen, Amanda O'Neill, Lisa Murphy, Yue Fan, Susie Boyce, Noel Fitzgerald, Emma Dorris, Lauren Brady, Stephen P. Finn, Brian D. Hayes, Ann Treacy, Ciara Barrett, Mardiana Abdul Aziz, Elaine W. Kay, John M. Fitzpatrick, R. William G. Watson Tags: ORIGINAL ARTICLE Source Type: research
Effect of radical prostatectomy on levels of cancer related epitopes in circulating macrophages of patients with clinically localized prostate cancer
ConclusionsThe present study demonstrates that surgical removal of the primary tumor leads to a significant decrease of Apo10 and TKTL1 expressing macrophages. This observation further encourages studies assessing the optimal clinical utility of EDIM‐based detection of Apo10 and TKTL1 in patients with PC. (Source: The Prostate)
Source: The Prostate - July 20, 2017 Category: Urology & Nephrology Authors: Tilman Todenh öfer, Jörg Hennenlotter, Gabriel Keller, Tim Neumann, Arnulf Stenzl, Jens Bedke Tags: ORIGINAL ARTICLE Source Type: research
Characterization of adenoviral transduction profile in prostate cancer cells and normal prostate tissue
ConclusionsOur findings suggest that Ad can efficiently transduce prostate tumor cells in vitro as well as xenograft and normal prostate tissue in vivo, and further indicate that Ad could be a potentially powerful toolbox for future gene therapy of prostate diseases. (Source: The Prostate)
Source: The Prostate - July 20, 2017 Category: Urology & Nephrology Authors: Jianzhong Ai, Phillip W.L. Tai, Yi Lu, Jia Li, Hong Ma, Qin Su, Qiang Wei, Hong Li, Guangping Gao Tags: ORIGINAL ARTICLE Source Type: research
Issue Information ‐ Editorial Board
(Source: The Prostate)
Source: The Prostate - July 18, 2017 Category: Urology & Nephrology Tags: ISSUE INFORMATION Source Type: research
Insight into infection ‐mediated prostate damage: Contrasting patterns of C‐reactive protein and prostate‐specific antigen levels during infection
ConclusionsThese findings, which differ from those for PSA, suggest distinct mechanisms of elevation for hsCRP and PSA, and support both direct (eg, prostate infection) and indirect (eg, systemic inflammation‐mediated prostate cell damage) mechanisms for PSA elevation. Future studies should explore our PSA findings further for their relevance to both prostate cancer screening and risk. (Source: The Prostate)
Source: The Prostate - July 1, 2017 Category: Urology & Nephrology Authors: Melissa Milbrandt, Anke C. Winter, Remington L. Nevin, Ratna Pakpahan, Gary Bradwin, Angelo M. De Marzo, Debra J. Elliott, Charlotte A. Gaydos, William B. Isaacs, William G. Nelson, Nader Rifai, Lori J. Sokoll, Jonathan M. Zenilman, Elizabeth A. Platz, Si Tags: ORIGINAL ARTICLE Source Type: research
Ductal adenocarcinoma of the prostate: Clinical and biological profiles
Conclusionthese results suggest that, despite biological differences that highlighted DAC aggressiveness, the molecular classification recently proposed in conventional PCa could also be applied in DAC. (Source: The Prostate)
Source: The Prostate - July 1, 2017 Category: Urology & Nephrology Authors: Armelle Vinceneux, Franck Bruy ère, Olivier Haillot, Thomas Charles, Alexandre de la Taille, Laurent Salomon, Yves Allory, Idir Ouzaid, Laurence Choudat, Morgan Rouprêt, Eva Comperat, Nadine Houede, Jean‐Baptiste Beauval, Patrick Vourc'h, Gaëlle From Tags: ORIGINAL ARTICLE Source Type: research
Reclassification of prostate cancer risk using sequentially identified SNPs: Results from the REDUCE trial
ConclusionsRisk assessment using currently available SNPs is justified. Multiple GRS values from evolving sets of SNPs provide a valuable tool for better refining risk. (Source: The Prostate)
Source: The Prostate - July 1, 2017 Category: Urology & Nephrology Authors: Haitao Chen, Rong Na, Vignesh T. Packiam, Carly A. Conran, Deke Jiang, Sha Tao, Hongjie Yu, Xiaoling Lin, Wei Meng, S. Lilly Zheng, Charles B. Brendler, Brian T. Helfand, Jianfeng Xu Tags: ORIGINAL ARTICLE Source Type: research
Prostate health index significantly reduced unnecessary prostate biopsies in patients with PSA 2 ‐10 ng/mL and PSA > 10 ng/mL: Results from a Multicenter Study in China
ConclusionsResults from this study suggest that phi can be used to predict PCa and high‐grade disease in Chinese men with high PSA levels (>10 ng/mL). (Source: The Prostate)
Source: The Prostate - June 30, 2017 Category: Urology & Nephrology Authors: Rong Na, Dingwei Ye, Jun Qi, Fang Liu, Brian T. Helfand, Charles B. Brendler, Carly A. Conran, Vignesh Packiam, Jian Gong, Yishuo Wu, Siqun L. Zheng, Zengnan Mo, Qiang Ding, Yinghao Sun, Jianfeng Xu Tags: ORIGINAL ARTICLE Source Type: research
