Macrophage roles in the clearance of apoptotic cells and control of inflammation in the prostate gland after castration
ConclusionsCD68+ macrophages phagocytose apoptotic cell corpses and activate the LAP pathway, thereby contributing to the preservation of a non‐inflammed microenvironment. Marked inflammation was detected when autophagy blockers were administered to castrated animals. (Source: The Prostate)
Source: The Prostate - November 14, 2017 Category: Urology & Nephrology Authors: Juliete A.F. Silva, Alexandre Bruni ‐Cardoso, Taize M. Augusto, Danilo M. Damas‐Souza, Guilherme O. Barbosa, Sérgio L. Felisbino, Dagmar R. Stach‐Machado, Hernandes F. Carvalho Tags: ORIGINAL ARTICLE Source Type: research
Altered mitochondrial genome content signals worse pathology and prognosis in prostate cancer
ConclusionsContrary to other cancer types, prostate cancer tissue shows no universally depleted mtDNA content. Rather, the change in mtDNA content is highly variable, mirroring known prostate cancer genome heterogeneity. Patients with high mtDNA content have an unfavorable pathology, while a high mtDNA content in normal adjacent prostate tissue is associated with worse prognosis. (Source: The Prostate)
Source: The Prostate - November 14, 2017 Category: Urology & Nephrology Authors: Anton M. F. Kalsbeek, Eva K. F. Chan, Judith Grogan, Desiree C. Petersen, Weerachai Jaratlerdsiri, Ruta Gupta, Ruth J. Lyons, Anne ‐Maree Haynes, Lisa G. Horvath, James G. Kench, Phillip D. Stricker, Vanessa M. Hayes Tags: ORIGINAL ARTICLE Source Type: research
Enhanced radiosensitization of enzalutamide via schedule dependent administration to androgen ‐sensitive prostate cancer cells
ConclusionsOur data indicates that ENZA acts as a much stronger radiosensitizer compared to ADT. We have also observed that its efficacy is schedule dependent and related to increased levels of DNA damage and a delay of DNA repair processes. Finally, the initial abrogation of DNA‐PKcs activity by AR inhibition and its subsequent recovery might represent an important mechanism by which PCa cells acquire resistance to combined anti‐androgen and XRT treatment. This work suggests a new use of ENZA in combination with XRT that could be applicable in clinical trial settings for patients with early and intermediate hormone re...
Source: The Prostate - November 14, 2017 Category: Urology & Nephrology Authors: Maryam Ghashghaei, Miltiadis Paliouras, Mitra Heravi, Hamed Bekerat, Mark Trifiro, Tamim M. Niazi, Thierry Muanza Tags: ORIGINAL ARTICLE Source Type: research
Influence of the neural microenvironment on prostate cancer
ConclusionNerves play a role in the homeostasis of normal epithelial tissues and are involved in prostate cancer tumor survival. This study confirms that interactions between human cancer and nerves are essential to disease progression. This work may make a major impact in general cancer treatment strategies, as nerve/cancer interactions are likely important in other cancers as well. Targeting the neural microenvironment may represent a therapeutic approach for the treatment of human prostate cancer. (Source: The Prostate)
Source: The Prostate - November 13, 2017 Category: Urology & Nephrology Authors: Christian Coarfa, Diego Florentin, NagiReddy Putluri, Yi Ding, Jason Au, Dandan He, Ahmed Ragheb, Anna Frolov, George Michailidis, MinJae Lee, Dov Kadmon, Brian Miles, Christopher Smith, Michael Ittmann, David Rowley, Arun Sreekumar, Chad J. Creighton, Gu Tags: ORIGINAL ARTICLE Source Type: research
Hyperlipidemia is associated with an increased risk of clinical benign prostatic hyperplasia
ConclusionsHyperlipidemia is associated with an increased risk of clinical BPH. (Source: The Prostate)
Source: The Prostate - November 9, 2017 Category: Urology & Nephrology Authors: Hung ‐Jen Shih, Chun‐Jen Huang, Jui‐An Lin, Ming‐Chang Kao, Yen‐Chun Fan, Pei‐Shan Tsai Tags: ORIGINAL ARTICLE Source Type: research
Milk and other dairy foods in relation to prostate cancer recurrence: Data from the cancer of the prostate strategic urologic research endeavor (CaPSURE ™)
ConclusionIn conclusion, whole milk consumption after prostate cancer diagnosis was associated with increased risk of recurrence, particularly among very overweight or obese men. Men with prostate cancer who choose to drink milk should select non‐fat or low‐fat options. (Source: The Prostate)
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: David Tat, Stacey A. Kenfield, Janet E. Cowan, Jeanette M. Broering, Peter R. Carroll, Erin L. Van Blarigan, June M. Chan Tags: ORIGINAL ARTICLE Source Type: research
Circulating microRNAs and treatment response in the Phase II SWOG S0925 study for patients with new metastatic hormone ‐sensitive prostate cancer
ConclusionsBaseline plasma miR‐141, miR‐200a, and miR‐375 levels are associated with baseline CTC count. Baseline miR‐375 was also associated with the trial endpoint of 28‐week PSA response. Our results provide evidence that circulating miRNA biomarkers may have value as prognostic biomarkers and warrant further study in larger prospective clinical trials. (Source: The Prostate)
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: Heather H. Cheng, Melissa Plets, Hongli Li, Celestia S. Higano, Catherine M. Tangen, Neeraj Agarwal, Nicholas J. Vogelzang, Maha Hussain, Ian M. Thompson, Muneesh Tewari, Evan Y. Yu Tags: ORIGINAL ARTICLE Source Type: research
The orally active pterocarpanquinone LQB ‐118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress
ConclusionLQB‐118 is a developing and orally active pterocarpanquinone agent that effectively kills PCa cells through quinone reduction and ROS generation. The inhibition SOD1 expression enhances LQB‐118 activity, presumably by impairing the cellular antioxidant response. (Source: The Prostate)
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: Thiago Martino, Tarana A. Kudrolli, Binod Kumar, Isis Salviano, Andr é Mencalha, Marsen Garcia P. Coelho, Graça Justo, Paulo R. Ribeiro Costa, Kátia C. Carvalho Sabino, Shawn E. Lupold Tags: ORIGINAL ARTICLE Source Type: research
GLUT1 regulates cell glycolysis and proliferation in prostate cancer
ConclusionsGLUT1 may play an important role in PCa progression via mediating glycolysis and proliferation. Our study also indicated a potential crosstalk between GLUT1‐mediated glycolysis and androgen sensitivity in PCa. (Source: The Prostate)
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: Hengjun Xiao, Jun Wang, Weixin Yan, Yubin Cui, Zheng Chen, Xin Gao, Xingqiao Wen, Jun Chen Tags: ORIGINAL ARTICLE Source Type: research
FOXP3+ regulatory T cells in normal prostate tissue, postatrophic hyperplasia, prostatic intraepithelial neoplasia, and tumor histological lesions in men with and without prostate cancer
ConclusionsOur results may suggest a possible pathway through which PAH develops directly into prostate cancer in the presence of CD4+ Tregs and indicate that transformation of the anti‐tumor immune response may be initiated even before the primary tumor is established. (Source: The Prostate)
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: Sabina Davidsson, Ove Andren, Anna ‐Lena Ohlson, Jessica Carlsson, Swen‐Olof Andersson, Francesca Giunchi, Jennifer R. Rider, Michelangelo Fiorentino Tags: ORIGINAL ARTICLE Source Type: research
Sarcosine influences apoptosis and growth of prostate cells via cell ‐type specific regulation of distinct sets of genes
ConclusionsOur comparative study brings evidence that sarcosine affects not only metastatic PCa cells, but also their malignant and non‐malignant counterparts and induces very similar changes in cells behavior, but via distinct cell‐type specific targets. (Source: The Prostate)
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: Miguel A. Merlos Rodrigo, Vladislav Strmiska, Eva Horackova, Hana Buchtelova, Petr Michalek, Marie Stiborova, Tomas Eckschlager, Vojtech Adam, Zbynek Heger Tags: ORIGINAL ARTICLE Source Type: research
Penetration and pharmacokinetics of non ‐steroidal anti‐inflammatory drugs in rat prostate tissue
ConclusionsThis study for the first time reported the relative prostate tissue penetration of four NSAIDs. The pharmacokinetic data indicated that celecoxib has the highest penetration and retention in rat prostate tissues. Therefore, celecoxib may be considered as a better choice for the treatment CP/CPPS involving NSAIDs. (Source: The Prostate)
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: Venkata K. Yellepeddi, Jayashree Radhakrishnan, Rajan Radhakrishnan Tags: ORIGINAL ARTICLE Source Type: research
99mTc ‐MIP‐1404‐SPECT/CT for the detection of PSMA‐positive lesions in 225 patients with biochemical recurrence of prostate cancer
ConclusionSPECT/CT with 99mTc‐labeled MIP‐1404 has a high probability in detecting PSMA‐positive lesions in patients with elevated PSA. Statistical analysis disclosed significant relationship between quantitative 99mTc‐MIP‐1404 uptake, PSA level, and Gleason score. (Source: The Prostate)
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: Christian Schmidkonz, Claudia Hollweg, Michael Beck, Julia Reinfelder, Theresa I. Goetz, James C. Sanders, Daniela Schmidt, Olaf Prante, Tobias B äuerle, Alexander Cavallaro, Michael Uder, Bernd Wullich, Peter Goebell, Torsten Kuwert, Philipp Ritt Tags: ORIGINAL ARTICLE Source Type: research
Estrogen receptor signaling in prostate cancer: Implications for carcinogenesis and tumor progression
ConclusionsIncreasing evidences demonstrate that local estrogen signaling mechanisms are required for prostate carcinogenesis and tumor progression. Despite the recent progress in this research topic, the translation of the current information into potential therapeutic applications remains highly challenging and clearly warrants further investigation. (Source: The Prostate)
Source: The Prostate - November 2, 2017 Category: Urology & Nephrology Authors: Helmut Bonkhoff Tags: REVIEW ARTICLE Source Type: research
Platelets harbor prostate cancer biomarkers and the ability to predict therapeutic response to abiraterone in castration resistant patients
ConclusionAnalyzing tumor‐derived biomarkers in platelets of CRPC patients enabled prediction of the outcome after abiraterone therapy with higher accuracy than baseline serum PSA or PSA response. (Source: The Prostate)
Source: The Prostate - November 2, 2017 Category: Urology & Nephrology Authors: Lee ‐Ann Tjon‐Kon‐Fat, Marie Lundholm, Mona Schröder, Thomas Wurdinger, Camilla Thellenberg‐Karlsson, Anders Widmark, Pernilla Wikström, Rolf Jonas Andreas Nilsson Tags: ORIGINAL ARTICLE Source Type: research
