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The Prostate, Ahead of Print. (Source: The Prostate)
Source: The Prostate - March 11, 2018 Category: Urology & Nephrology Source Type: research
PBOV1 as a potential biomarker for more advanced prostate cancer based on protein and digital histomorphometric analysis
ConclusionsOur study demonstrates that the PBOV1 protein could be used to discriminate Grade Group 3 and above PCa. Additionally, the PBOV1 protein could be involved in modulating changes to the nuclear architecture of PCa cells. Confirmatory studies are warranted in an independent population for further validation. (Source: The Prostate)
Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Authors: Neil M. Carleton, Guangjing Zhu, Mikhail Gorbounov, M. Craig Miller, Kenneth J. Pienta, Linda M. S. Resar, Robert W. Veltri Tags: ORIGINAL ARTICLE Source Type: research
Detectable end of radiation prostate specific antigen assists in identifying men with unfavorable intermediate ‐risk prostate cancer at high risk of distant recurrence and cancer‐specific mortality
The Prostate, EarlyView. (Source: The Prostate)
Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Source Type: research
PBOV1 as a potential biomarker for more advanced prostate cancer based on protein and digital histomorphometric analysis
The Prostate, EarlyView. (Source: The Prostate)
Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Source Type: research
Exploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data ‐independent acquisition (DIA) mass spectrometry
The Prostate, EarlyView. (Source: The Prostate)
Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Source Type: research
The composition of prostate core matrisome in vivo and in vitro unveiled by mass spectrometric analysis
The Prostate, EarlyView. (Source: The Prostate)
Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Source Type: research
A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancer
The Prostate, EarlyView. (Source: The Prostate)
Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Source Type: research
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The Prostate, Ahead of Print. (Source: The Prostate)
Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Source Type: research
A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancer
ConclusionsWhile overall CHEK2 mutations were not significantly more common in men with lethal compared to low‐risk PCa, the specific CHEK2 mutation, c.1100delC, appears to contribute to an increased risk of lethal PCa in European American men. (Source: The Prostate)
Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Authors: Yishuo Wu, Hongjie Yu, S. Lilly Zheng, Rong Na, Mufaddal Mamawala, Tricia Landis, Kathleen Wiley, Jacqueline Petkewicz, Sameep Shah, Zhuqing Shi, Kristian Novakovic, Michael McGuire, Charles B. Brendler, Qiang Ding, Brian T. Helfand, H. Ballentine Carter, Tags: ORIGINAL ARTICLE Source Type: research
The composition of prostate core matrisome in vivo and in vitro unveiled by mass spectrometric analysis
ConclusionsArtificial activation of ECM remodeling seems to be a distinctive feature in in vitro models. In conclusion the constitution of ECM produced by prostate derived fibroblasts in vitro is similar, but not identical to the prostate ECM in vivo as shown here by mass spectrometric analysis. (Source: The Prostate)
Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Authors: Marjaana Ojalill, Pekka Rappu, Elina Siljam äki, Pekka Taimen, Peter Boström, Jyrki Heino Tags: ORIGINAL ARTICLE Source Type: research
Exploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data ‐independent acquisition (DIA) mass spectrometry
DiscussionIn this prospective study, we have established a sensitive and reliable oncoproteomic pipeline for the analysis of both fresh and formalin‐fixed human PCa tissue. We identified multiple pathways known to be radiation‐responsive and have established a powerful database of candidates and pathways with no current association with RT. This information may be beneficial in the advancement of personalized therapies and potentially, predictive biomarkers. (Source: The Prostate)
Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Authors: Simon P. Keam, Twishi Gulati, Cristina Gamell, Franco Caramia, Cheng Huang, Ralf B. Schittenhelm, Oded Kleifeld, Paul J. Neeson, Ygal Haupt, Scott G. Williams Tags: ORIGINAL ARTICLE Source Type: research
