Exploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data ‐independent acquisition (DIA) mass spectrometry

DiscussionIn this prospective study, we have established a sensitive and reliable oncoproteomic pipeline for the analysis of both fresh and formalin‐fixed human PCa tissue. We identified multiple pathways known to be radiation‐responsive and have established a powerful database of candidates and pathways with no current association with RT. This information may be beneficial in the advancement of personalized therapies and potentially, predictive biomarkers.

Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Authors: Simon P. Keam, Twishi Gulati, Cristina Gamell, Franco Caramia, Cheng Huang, Ralf B. Schittenhelm, Oded Kleifeld, Paul J. Neeson, Ygal Haupt, Scott G. Williams Tags: ORIGINAL ARTICLE Source Type: research