A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancer

ConclusionsWhile overall CHEK2 mutations were not significantly more common in men with lethal compared to low‐risk PCa, the specific CHEK2 mutation, c.1100delC, appears to contribute to an increased risk of lethal PCa in European American men.

Source: The Prostate - March 9, 2018 Category: Urology & Nephrology Authors: Yishuo Wu, Hongjie Yu, S. Lilly Zheng, Rong Na, Mufaddal Mamawala, Tricia Landis, Kathleen Wiley, Jacqueline Petkewicz, Sameep Shah, Zhuqing Shi, Kristian Novakovic, Michael McGuire, Charles B. Brendler, Qiang Ding, Brian T. Helfand, H. Ballentine Carter, Tags: ORIGINAL ARTICLE Source Type: research