A subset of high Gleason grade prostate carcinomas contain a large burden of prostate cancer syndecan ‐1 positive stromal cells

ConclusionsThe current study identifies PCSP cells as a novel, potentially migratory cell type, which is marked by Syndecan‐1 expression and is found in the stroma of prostate carcinomas, adjacent normal tissue, but not in non‐diseased prostate. A subset of poor prognosis high Gleason grade 5 tumors had a particularly high PCSP cell burden, suggesting an association between this unidentified cell type and tumor aggressiveness.

Source: The Prostate - July 26, 2017 Category: Urology & Nephrology Authors: Benjamin Sharpe, Dhafer A. Alghezi, Claire Cattermole, Mark Beresford, Rebecca Bowen, John Mitchard, Andrew D. Chalmers Tags: ORIGINAL ARTICLE Source Type: research