Intraductal/ductal histology and lymphovascular invasion are associated with germline DNA ‐repair gene mutations in prostate cancer

ConclusionsPresence of intraductal/ductal histology and lymphovascular invasion appear to be associated with pathogenic germline DNA‐repair gene mutations in men with prostate cancer, and identification of these features may help to select patients for germline testing. NCCN guidelines may be inadequate in predicting which prostate cancer patients should undergo genetic screening.

Source: The Prostate - January 25, 2018 Category: Urology & Nephrology Authors: Pedro Isaacsson Velho, John L. Silberstein, Mark C. Markowski, Jun Luo, Tamara L. Lotan, William B. Isaacs, Emmanuel S. Antonarakis Tags: ORIGINAL ARTICLE Source Type: research