A carbon 21 steroidal metabolite from progestin, 20 β‐hydroxy‐5α‐dihydroprogesterone, stimulates the androgen receptor in prostate cancer cells

ConclusionsUnder ADT, 20β‐OHDHP synthesized intracellularly from accumulated progestin in PC cells may accelerate cell growth via stimulation of both wAR and mAR. This pathway may represent an interesting candidate for targeted therapy.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fpros.23460

Source: The Prostate - December 1, 2017 Category: Urology & Nephrology Authors: Takashi Ando, Tsutomu Nishiyama, Itsuhiro Takizawa, Yoshimichi Miyashiro, Noboru Hara, Yoshihiko Tomita Tags: ORIGINAL ARTICLE Source Type: research