GOLM1 promotes prostate cancer progression through activating PI3K ‐AKT‐mTOR signaling

ConclusionGOLM1 acts as a critical oncogene by promoting PCa cell proliferation, migration and invasion, and inhibiting apoptosis. GOLM1 plays oncogenic functions mainly through activating PI3K‐AKT‐mTOR signaling pathway. Therefore, agents that block PI3K‐AKT‐mTOR signaling pathway could be used in PCa patients with GOLM1 up‐regulation.

Source: The Prostate - November 28, 2017 Category: Urology & Nephrology Authors: Guang Yan, Yi Ru, Kerong Wu, Fengqi Yan, Qinhao Wang, Jingxiang Wang, Tao Pan, Mei Zhang, Hua Han, Xia Li, Lian Zou Tags: REVIEW ARTICLE Source Type: research