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Did AFP-L3 save ultrasonography in community screening?
Publication date: Available online 11 June 2018Source: The Kaohsiung Journal of Medical SciencesAuthor(s): Chih-Wei Yen, Yuan-Hung Kuo, Jing-Houng Wang, Kuo-Chin Chang, Kwong-Ming Kee, Shu-Feng Hung, Yi Chen, Lin-San Tsai, Shu-Chuan Chen, Chao-Hung Hung, Sheng-Nan LuAbstractIn the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the u...
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

Reduced exosome miR-425 and miR-744 in the plasma represents the progression of fibrosis and heart failure
In this study, we detected the expression of 9 candidate miRNAs in the plasma exosome samples from 31 HF patients, and found the level of miR-21, miR-425 and miR-744 was altered. The downregulation of miR-425 and miR-744 was also found in angiotensin II treated cardiac fibroblasts. Through functional study, we identified that the reduction of miR-425 and miR-744 relates to overexpression of collagen 1 and α-SMA, which result in fibrogenesis of cardiac fibroblasts. Conversely, overexpression of miR-425 or miR-744 in cultured cardiac fibroblasts significantly abrogates angiotensin induced collagen formation and fibrogenesis...
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

Stitch guide technique for bicanalicular nasal intubation in single canalicular laceration reconstruction
We present a simple and effective way to achieve the bicanalicular nasal intubation for the single canalicular laceration. From Jan 2005 to Dec 2015, 20 patients (21 eyes) with upper or lower canalicular laceration were treated with the Crawford lacrimal intubation set by this stitch guide method. We used the eye pigtail probe and the steel probe of the intubation set to dispose a 4-0 Nylon suture as a guide to pull down the silicone tube to the nostril. The functional and anatomic success rates in the 20 eyes are 90% (18/20) and 85% (17/20) respectively. The average time for bicanalicular nasal intubation by this method i...
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

Lentiviral-mediated microRNA-26b up-regulation inhibits proliferation and migration of hepatocellular carcinoma cells
This study aims to investigate the effects of lentiviral-mediated miRNA-26b (miR-26b) on the proliferation and metastasis of HCC cells. The normal hepatic cell line HL-7702 and HCC cell lines HepG2 (without metastatic potential), SMMC-7721 (with low metastatic potential) and MHCC97H (with high metastatic potential) were purchased for our experiment. The lentiviral-mediated miR-26b overexpression (miR-26b-LV) and low expression (sh-miR-26b) were constructed to transfect the cells. The miR-26b expression and expressions of Karyopherin α-2 (KPNA2), matrix metalloproteinase 1 (MMP-1), MMP-7 and MMP-14 were determined by RT-qP...
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

Early functional improvement after stroke correlates with cardiovascular fitness
In conclusion, these results suggest that cardiovascular fitness appears to increase after complementary program in early stroke rehabilitation, and better cardiovascular fitness may be associated with greater functional improvement. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms
This study suggested that the presence of lymphatic or distant metastases at diagnosis is an independent risk factor for poor prognosis in patients with GEP-NENs. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

Reversible pisa syndrome related to the interaction between lithium and clotiapine: Case report
Publication date: Available online 28 June 2018Source: The Kaohsiung Journal of Medical SciencesAuthor(s): Sheng-Yun Huang, Min-Wei Huang, Shih-Yen Tseng, Li-Chung Huang (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

Sequential bilateral PVTT successfully controlled by radiotherapy and sorafenib, respectively
Publication date: Available online 30 June 2018Source: The Kaohsiung Journal of Medical SciencesAuthor(s): Yung-Ning Huang, Yang-Bor Lu, Sheng-Nan Lu (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

Effects of perineural invasion in prostate needle biopsy on tumor grade and biochemical recurrence rates after radical prostatectomy
Publication date: July 2018Source: The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 7Author(s): Serdar Celik, Ozan Bozkurt, Omer Demir, Ozgur Gurboga, Burcin Tuna, Kutsal Yorukoglu, Guven AslanAbstractTo predict local invasive disease before retropubic radical prostatectomy (RRP), the correlation of perineural invasion (PNI) on prostate needle biopsy (PNB) and RRP pathology data and the effect of PNI on biochemical recurrence (BR) were researched. For patients with RRP performed between 2005 and 2014, predictive and pathologic prognostic factors were assessed. Initially all and D'Amico intermediate-risk group pa...
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

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Publication date: July 2018Source: The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 7Author(s): (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

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Publication date: July 2018Source: The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 7Author(s): (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

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Publication date: July 2018Source: The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 7Author(s): (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

Recent review of transcatheter closure of atrial septal defect
Publication date: July 2018Source: The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 7Author(s): Ming-Chun Yang, Jiunn-Ren WuAbstractAtrial septal defect (ASD) is one of the two most common congenital heart diseases in children and adult. After the application of catheter intervention for ASD, this became an alternative treatment other than surgery from late 1990. In 2001, the procedure was further approved by the US Food and Drug Administration (FDA), and become the first choice for most cases of secundum type of ASD worldwide. The success rate is more than 98% in literature reviews, with low complication rates ...
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

IGF-1 defends against chronic-stress induced depression in rat models of chronic unpredictable mild stress through the PI3K/Akt/FoxO3a pathway
This study aims to investigate the role of IGF-1 in chronic-stress induced depression through the PI3K/Akt/FoxO3a pathway. A rat model of chronic unpredictable mild stress (CUMS) was established. In total, 48 rats were randomized into control (normal rats), CUMS (CUMS modeled rats) and CUMS + IGF-1 (injection of IGF-1 before CUMS modeling) groups. Body weight, horizontal (number of horizontal crossing) and vertical activity (rearing times), and sucrose consumption were identified one day before and after the open-field test. The mRNA and protein expression of PI3K, Akt, FoxO3a and Bim in the hippocampus was measured by R...
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research

MiR-217 is involved in the carcinogenesis of gastric cancer by down-regulating CDH1 expression
In conclusion, we constructed the negative correlation between miR-217 and CDH1 level in GC patients and cells; unveiled part of the miR-217 function during the pathogenesis of GC. These findings may give insight into understanding the mechanism of GC pathogenesis and provide new biomarkers for clinical diagnosis. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2018 Category: Universities & Medical Training Source Type: research