The coexistence of Cushing syndrome and gynecomastia as the manifestations of adrenocortical carcinoma
Publication date: Available online 4 July 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Mongkontida Umphonsathien, Panudda Srichomkwun, Patinut Buranasupkajorn, Thiti Snabboon (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 5, 2018 Category: Universities & Medical Training Source Type: research

Sequential bilateral PVTT successfully controlled by radiotherapy and sorafenib, respectively
Publication date: Available online 30 June 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Yung-Ning Huang, Yang-Bor Lu, Sheng-Nan Lu (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 1, 2018 Category: Universities & Medical Training Source Type: research

Influence of tidal volume on ventilation distribution and oxygenation during one-lung  ventilation
Publication date: July 2018 Source:The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 7 Author(s): Wei Wang, Mei-Ying Xu, Jing-Xiang Wu, Zhan-Qi Zhao (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - June 30, 2018 Category: Universities & Medical Training Source Type: research

Simplified scoring system for prediction of mortality in acute suppurative cholangitis
Publication date: July 2018 Source:The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 7 Author(s): Barış Doğu Yıldız, Sabri Özden, Barış Saylam, Fahri Martlı, Mesut Tez Our objective in this study was to identify the factors contributing to mortality in acute suppurative cholangitis which could be tested easily in every emergency clinic. This is a retrospective study enrolling 104 patients with acute suppurative cholangitis. Demographic and laboratory data were collected for analysis. In univariant analysis red cell distribution width, total bilirubin level, intensive care unit admission was identi...
Source: The Kaohsiung Journal of Medical Sciences - June 30, 2018 Category: Universities & Medical Training Source Type: research

Effects of perineural invasion in prostate needle biopsy on tumor grade and biochemical recurrence rates after radical prostatectomy
Publication date: July 2018 Source:The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 7 Author(s): Serdar Celik, Ozan Bozkurt, Omer Demir, Ozgur Gurboga, Burcin Tuna, Kutsal Yorukoglu, Guven Aslan To predict local invasive disease before retropubic radical prostatectomy (RRP), the correlation of perineural invasion (PNI) on prostate needle biopsy (PNB) and RRP pathology data and the effect of PNI on biochemical recurrence (BR) were researched. For patients with RRP performed between 2005 and 2014, predictive and pathologic prognostic factors were assessed. Initially all and D'Amico intermediate-risk group...
Source: The Kaohsiung Journal of Medical Sciences - June 30, 2018 Category: Universities & Medical Training Source Type: research

Reversible pisa syndrome related to the interaction between lithium and clotiapine: Case report
Publication date: Available online 28 June 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Sheng-Yun Huang, Min-Wei Huang, Shih-Yen Tseng, Li-Chung Huang (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - June 29, 2018 Category: Universities & Medical Training Source Type: research

Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms
This study suggested that the presence of lymphatic or distant metastases at diagnosis is an independent risk factor for poor prognosis in patients with GEP-NENs. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - June 21, 2018 Category: Universities & Medical Training Source Type: research

Early functional improvement after stroke correlates with cardiovascular fitness
In conclusion, these results suggest that cardiovascular fitness appears to increase after complementary program in early stroke rehabilitation, and better cardiovascular fitness may be associated with greater functional improvement. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - June 16, 2018 Category: Universities & Medical Training Source Type: research

Did AFP-L3 save ultrasonography in community screening?
Publication date: Available online 11 June 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Chih-Wei Yen, Yuan-Hung Kuo, Jing-Houng Wang, Kuo-Chin Chang, Kwong-Ming Kee, Shu-Feng Hung, Yi Chen, Lin-San Tsai, Shu-Chuan Chen, Chao-Hung Hung, Sheng-Nan Lu In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, bu...
Source: The Kaohsiung Journal of Medical Sciences - June 12, 2018 Category: Universities & Medical Training Source Type: research

Reduced exosome miR-425 and miR-744 in the plasma represents the progression of fibrosis and heart failure
In this study, we detected the expression of 9 candidate miRNAs in the plasma exosome samples from 31 HF patients, and found the level of miR-21, miR-425 and miR-744 was altered. The downregulation of miR-425 and miR-744 was also found in angiotensin II treated cardiac fibroblasts. Through functional study, we identified that the reduction of miR-425 and miR-744 relates to overexpression of collagen 1 and α-SMA, which result in fibrogenesis of cardiac fibroblasts. Conversely, overexpression of miR-425 or miR-744 in cultured cardiac fibroblasts significantly abrogates angiotensin induced collagen formation and fibrogenesis...
Source: The Kaohsiung Journal of Medical Sciences - June 12, 2018 Category: Universities & Medical Training Source Type: research

Stitch guide technique for bicanalicular nasal intubation in single canalicular laceration reconstruction
We present a simple and effective way to achieve the bicanalicular nasal intubation for the single canalicular laceration. From Jan 2005 to Dec 2015, 20 patients (21 eyes) with upper or lower canalicular laceration were treated with the Crawford lacrimal intubation set by this stitch guide method. We used the eye pigtail probe and the steel probe of the intubation set to dispose a 4-0 Nylon suture as a guide to pull down the silicone tube to the nostril. The functional and anatomic success rates in the 20 eyes are 90% (18/20) and 85% (17/20) respectively. The average time for bicanalicular nasal intubation by this method i...
Source: The Kaohsiung Journal of Medical Sciences - June 12, 2018 Category: Universities & Medical Training Source Type: research

Lentiviral-mediated microRNA-26b up-regulation inhibits proliferation and migration of hepatocellular carcinoma cells
This study aims to investigate the effects of lentiviral-mediated miRNA-26b (miR-26b) on the proliferation and metastasis of HCC cells. The normal hepatic cell line HL-7702 and HCC cell lines HepG2 (without metastatic potential), SMMC-7721 (with low metastatic potential) and MHCC97H (with high metastatic potential) were purchased for our experiment. The lentiviral-mediated miR-26b overexpression (miR-26b-LV) and low expression (sh-miR-26b) were constructed to transfect the cells. The miR-26b expression and expressions of Karyopherin α-2 (KPNA2), matrix metalloproteinase 1 (MMP-1), MMP-7 and MMP-14 were determined by RT-qP...
Source: The Kaohsiung Journal of Medical Sciences - June 12, 2018 Category: Universities & Medical Training Source Type: research

MicroRNA-21 is upregulated during intestinal barrier dysfunction induced by ischemia reperfusion
In conclusion, miR-21 expression is upregulated during intestinal barrier dysfunction induced by IRI. miR-21 may play an important role in the regulation of intestinal barrier function. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - June 8, 2018 Category: Universities & Medical Training Source Type: research

Role of PERK-eIF2 α signaling pathway in fetal male rats with hypospadias induced by di-n-butyl phthalate
This study aims to explore the role of PERK-eIF2α signaling pathway in fetal male rats with hypospadias induced by maternal exposure to di-n-butyl phthalate (DBP). DBP was used to treat pregnant SD rats by gastric intubation from gestation day (GD) 14–18 to construct a hypospadias rat model. The amount, weight, anogenital distance (AGD), and hypospadias incidence of rats were recorded and the genital tubercle (GT) of fetal male rats was collected on GD 19. Western blotting was performed to detect the expressions of PERK-eIF2α pathway- and autophagy-related proteins, and cell apoptosis was detected using TUNEL method. T...
Source: The Kaohsiung Journal of Medical Sciences - June 5, 2018 Category: Universities & Medical Training Source Type: research

Prognostic predictive value of TLR4 polymorphisms in Han Chinese population with hypertrophic cardiomyopathy
Publication date: Available online 2 June 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Ke Han, Yan-Ping Li Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disease and is an important cause of sudden death in patients of all ages. The aim of this study was to find out whether Toll-like receptor-4 (TLR4) polymorphism is associated with HCM. To explore the association between TLR4 gene polymorphisms and HCM, 486 HCM patients and 214 healthy controls were enrolled in a case–control study of Chinese Han population. Two single nucleotide polymorphisms (SNPs) in the promoter region o...
Source: The Kaohsiung Journal of Medical Sciences - June 3, 2018 Category: Universities & Medical Training Source Type: research