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Impaired cutaneous T-cell attracting chemokine elevation and adipose-derived stromal cell migration in a high-glucose environment cause poor diabetic wound healing
In this study, we introduced adipose-derived stromal cells (ADSCs) into wound sites and demonstrated that the local transplantation of ADSCs accelerated DM-related wound healing. Furthermore, the migration ability of ADSCs, which diminishes in a high-glucose environment, was partially restored by the exogenous replenishment of the cutaneous T-cell attracting chemokine (CTACK/CCL27). Our findings suggest that CTACK is a potential novel therapeutic target in DM-related wound healing. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - May 31, 2018 Category: Universities & Medical Training Source Type: research

Recent review of transcatheter closure of atrial septal defect
Publication date: Available online 30 May 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Ming-Chun Yang, Jiunn-Ren Wu Atrial septal defect (ASD) is one of the two most common congenital heart diseases in children and adult. After the application of catheter intervention for ASD, this became an alternative treatment other than surgery from late 1990. In 2001, the procedure was further approved by the US Food and Drug Administration (FDA), and become the first choice for most cases of secundum type of ASD worldwide. The success rate is more than 98% in literature reviews, with low complication rates in ...
Source: The Kaohsiung Journal of Medical Sciences - May 31, 2018 Category: Universities & Medical Training Source Type: research

Mir-483 inhibits colon cancer cell proliferation and migration by targeting TRAF1
Publication date: Available online 24 May 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Zi-Yu Niu, Wen-Li Li, Da-Lei Jiang, Yan-Song Li, Xiang-Jun Xie MicroRNAs are important regulators during human growth and development. Emerging evidence indicates that microRNAs play important roles in colorectal cancer. The aim of this study is to reveal the biological function and direct target gene of miR-483 in colorectal cancer. The biological function of miR-483 on the proliferation and migration of colon cancer cells was then examined by Edu assay and transwell assay, respectively. Our findings revealed ...
Source: The Kaohsiung Journal of Medical Sciences - May 25, 2018 Category: Universities & Medical Training Source Type: research

Senior-L øken syndrome with IQCB1 mutation in Taiwan
Publication date: Available online 19 April 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Pei-Hua Yu, Yuh-Ren Kuo, Janine Altmüller, Daw-Yang Hwang (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research

Metabolic syndrome and vaspin in patients with bipolar disorder
Publication date: Available online 24 April 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Hulya Ertekin, Basak Sahin, Ali Metehan Caliskan, Ikbal Inanli, Yusuf Haydar Ertekin Metabolic disorders and abnormal levels of circulating adipokines have been reported in patients with bipolar disorder (BD). The aim of this study was to investigate the differences in the correlations of vaspin plasma levels and metabolic parameters between two groups: patients with BD and mentally healthy persons. We measured plasma levels of vaspin, metabolic parameters, and metabolic syndrome (MS) in 101 patients with BD ...
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research

Neuroprotective effect of tanshinone IIA against neuropathic pain in diabetic rats through the Nrf2/ARE and NF- κB signaling pathways
Publication date: Available online 27 April 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Fa-Bo Feng, Hai-Yan Qiu The study aims to investigate whether tanshinone (TSN) IIA affects diabetic neuropathic pain (DNP) via the Nrf2/AR and NF-κB signaling pathways. Rats were randomly assigned into DNP group, TSN group (injected with TSN IIA), TSN + DRB group (injected with TSN IIA and 15 mg/kg Nrf2/ARE inhibitors), TSN + PDTC group (injected with TSN IIA and 60 mg/kg NF-κB inhibitors) or control group. The first four groups were successfully established as DNP models after injection of streptozotoci...
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research

Effect of blood purification on serum miR-126 and VEGF levels in the process of atherosclerosis in uremic patients under maintenance hemodialysis
This study aims to study the influence of different blood purification approaches on the expression of miR-126 and VEGF serum levels in the development of atherosclerosis in uremic patients under maintenance hemodialysis (MHD). A total of 207 MHD patients with uremia were divided into HD (hemodialysis, n = 60), HDF (hemodiafiltration, n = 72), and HD + HP (hemodialysis + hemoperfusion, n = 75) groups based on different purification approaches. Eighty individuals who underwent physical examinations during the same period constituted the healthy controls. The serum levels of miR-126 and VEGF were examined by qRT-PC...
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research

Ultrasound-guided intertumoral injection of contrast agents combined with human p53 gene for the treatment of breast cancer
The objective of this study was to investigate the effects of ultrasound-guided injection of ultrasound contrast agents (UCAs) and the p53 gene on the treatment of rats with breast cancer (BC). Assembly of the p53 expression vector as well as that of a rat model with BC consisted of 200 successfully modeled rats randomly divided into 5 groups: p53 gene introduction, p53 gene introduction + ultrasound irradiation, p53 gene introduction + UCAs, p53 gene introduction + UCA + ultrasound irradiation, and UCA + ultrasound irradiation groups. Expression of p53 was detected via quantitative real-time polymerase chain rea...
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research

Eruptive vellus hair cysts in an unusual location with atypical pathological features
Publication date: May 2018 Source:The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 5 Author(s): Yang-Yi Chen, Cheng-Che E. Lan (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research

Increased frequency of AMP-activated protein kinase-positive spinal motor neurons after sciatic nerve injury in a mouse model
In this study, we used a sciatic nerve crushed mouse model to detect the expression of AMPK in sciatic nerve and spinal motor neurons at 1 week, 2 weeks and 3 weeks after injury by immunofluorescence staining. Electrophysiological and histopathological studies were used to confirm the nerve injury and regeneration. Our results showed that frequency of AMPK-positive spinal motor neurons was significantly higher on day 7 after sciatic nerve crush (SNC) and peaked on day 14. No expression of AMPK was detected in axons of the sciatic nerve before and after the injury. Taken together, our study suggested a possible role of AMPK...
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research

Risk factors for nasal bleeding in patients undergoing transnasal gastrointestinal endoscopy
Publication date: May 2018 Source:The Kaohsiung Journal of Medical Sciences, Volume 34, Issue 5 Author(s): Mitsuyo Mieda, Hiroshi Miyashita, Hiroyuki Osawa, Tomosuke Hirasawa, Nobuko Makino, Sachiko Toma, Takeshi Tomiyama, Yoshimasa Miura, Alan K. Lefor, Hironori Yamamoto Transnasal endoscopy is widely used in screening for upper gastrointestinal lesions because of less associated pain. Nasal bleeding is the most severe adverse effect, but specific risk factors have not been identified. The aim of this study is to identify risk factors for nasal bleeding during transnasal endoscopy. Nasal bleeding occurred in 1...
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research

Definite intensity-modulated radiotherapy with concurrent chemotherapy more than 4 cycles improved survival for patients with locally-advanced or inoperable esophageal squamous cell carcinoma
In conclusion, definite radiotherapy with concurrent chemotherapy ≥4 cycles improved the survival for patients with inoperable or locally-advanced esophageal squamous cell carcinoma. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research

Alteration in CD8+ T cell subsets in enterovirus-infected patients: An alarming factor for type 1 diabetes mellitus
This study was conducted to investigate the relationship between enteroviral infection and type 1 diabetes mellitus in an Iranian population, and suggestion a predicting approach for susceptible subjects. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research

Downregulated MALAT1 relates to recurrent pregnancy loss via sponging miRNAs
In conclusion, MALAT1 as a functional lncRNA controls cell proliferation, apoptosis, migration, invasion and modulates blood vessel formation. Down regulated MALAT1 induced disordered cross-talk between embryo and mother is one of the factor contributes to the pathogenesis of RPL. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research

Hepatic epithelioid hemangioendothelioma: Challenges in the preoperative diagnosis
Publication date: Available online 18 May 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Lan Zhang, Xin-Ju Chen, Jeong-Min Lee, Song-Shei Lin (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: research