Relationship of the MTHFD1 (rs2236225), eNOS (rs1799983), CBS (rs2850144) and ACE (rs4343) gene polymorphisms in a population of Iranian pediatric patients with congenital heart defects
Publication date: Available online 13 July 2017 Source:The Kaohsiung Journal of Medical Sciences Author(s): Mehri Khatami, Farzaneh Morteza Ratki, Saba Tajfar, Fatemeh Akrami Congenital heart defects are structural cardiovascular malformations that arise from abnormal formation of the heart or major blood vessels during the fetal period. To investigate the association of 4 single nucleotide polymorphisms (SNPs) in the MTHFD1, eNOS, CBS and ACE genes, we evaluated their relationship with CHD in Iranian patients. In this case–control study, a total of 102 children with CHD and 98 control children were enrolled. Four ...
Source: The Kaohsiung Journal of Medical Sciences - July 13, 2017 Category: Universities & Medical Training Source Type: research

Genetic diversity of multidrug-resistant Mycobacterium tuberculosis strains isolated from tuberculosis patients in Iran using MIRU-VNTR technique
In conclusion, this result represents MIRU-VNTR typing as a useful tool for studying genetic diversity of MDR-MTB in regional settings, and will help the health sectors to construct a preventive program for MDR-TB. Additionally, it can detect mixed infection which can facilitate management of treatment. (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 13, 2017 Category: Universities & Medical Training Source Type: research

Reply to “cost effectiveness of hepatitis C treatments: Need for a comprehensive evaluation”
Publication date: Available online 13 July 2017 Source:The Kaohsiung Journal of Medical Sciences Author(s): Pei-Chien Tsai, Ta-Wei Liu, Ming-Lung Yu (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - July 13, 2017 Category: Universities & Medical Training Source Type: research

Placental apoptosis in recurrent miscarriage
Publication date: Available online 13 July 2017 Source:The Kaohsiung Journal of Medical Sciences Author(s): Tarek A. Atia Apoptosis is an interactive and dynamic biological process involved in all phases of embryogenesis. We aimed to study the effect of placental apoptosis on recurrent miscarriage (RM). Placental tissue samples were collected from 40 women with RM (study group) and 30 women with sporadic spontaneous abortion (control group). Samples were prepared and stained immunohistochemically with markers for both the apoptotic protein (p53) and anti-apoptotic Bcl-2 antibodies. Our results showed that expression of ...
Source: The Kaohsiung Journal of Medical Sciences - July 13, 2017 Category: Universities & Medical Training Source Type: research

miR-206 enhances nasopharyngeal carcinoma radiosensitivity by targeting IGF1
Publication date: Available online 10 July 2017 Source:The Kaohsiung Journal of Medical Sciences Author(s): Tian Wang, Xin-Min Dong, Fu-Lin Zhang, Ji-Ren Zhang Radioresistance remains a major problem in nasopharyngeal carcinoma (NPC) treatment. However, the underlying molecular mechanisms of NPC radioresistance remain poorly understood. The present study aimed to investigate the potential role and mechanism of miR-206 in NPC radioresistance. We observed that miR-206 was down-regulated in radioresistant NPC cells. Furthermore, restoration of miR-206 in CNE2-IR cells suppressed enhanced radiosensitivity of NPC cells. I...
Source: The Kaohsiung Journal of Medical Sciences - July 10, 2017 Category: Universities & Medical Training Source Type: research