Long sleep duration and health outcomes: A systematic review, meta-analysis and meta-regression
We examined the dose-response relationship between long sleep duration and health outcomes including mortality and the incidence of diabetes mellitus, hypertension, cardiovascular diseases, stroke, coronary heart diseases, obesity, depression and dyslipidemia. We collected data from 5,134,036 participants from 137 prospective cohort studies. For the independent variable, we categorized participants at baseline as having long sleep duration or normal sleep duration. Risk ratios (RRs) for mortality and incident health conditions during follow-up were calculated through meta-analyses of adjusted data from individual studies. ...
Source: Sleep Medicine Reviews - July 4, 2017 Category: Sleep Medicine Authors: Maki Jike, Osamu Itani, Norio Watanabe, Daniel J. Buysse, Yoshitaka Kaneita Tags: Clinical Review Source Type: research

Insomnia disorder in adolescence: Diagnosis, impact, and treatment
Insomnia disorder is very common in adolescents; it is particularly manifest in older adolescents and girls, with a prevalence comparable to that of other major psychiatric disorders (e.g., depressive disorders). However, insomnia disorder in adolescence is poorly characterized, under-recognized, under-diagnosed, and under-treated, and the reason for the female preponderance for insomnia that emerges after puberty is largely unknown. Insomnia disorder goes beyond an individual complaint of poor sleep or a sleep state misperception, and there is emerging evidence supporting the association of insomnia symptoms in adolescent...
Source: Sleep Medicine Reviews - July 1, 2017 Category: Sleep Medicine Authors: Massimiliano de Zambotti, Aimee Goldstone, Ian M. Colrain, Fiona C. Baker Tags: Clinical Review Source Type: research

Insomnia disorder in adolescence: diagnosis, impact, and treatment
Insomnia disorder is very common in adolescents; it is particularly manifest in older adolescents and girls, with a prevalence comparable to that of other major psychiatric disorders (e.g., depressive disorders). However, insomnia disorder in adolescence is poorly characterized, under-recognized, under-diagnosed, and under-treated, and the reason for the female preponderance for insomnia that emerges after puberty is largely unknown. Insomnia disorder goes beyond an individual complaint of poor sleep or a sleep state misperception, and there is emerging evidence supporting the association of insomnia symptoms in adolescent...
Source: Sleep Medicine Reviews - July 1, 2017 Category: Sleep Medicine Authors: Massimiliano de Zambotti, Aimee Goldstone, Ian M. Colrain, Fiona C. Baker Tags: Clinical Review Source Type: research

Phenotypic approaches to positional therapy for obstructive sleep apnoea
I thank Drs. Oksenberg and Gadoth for highlighting the important role that positional therapy may play in the treatment of obstructive sleep apnoea (OSA) according to a phenotypic approach [1]. The recent phenotyping review in this journal [2] focused on physiological mechanisms with potential clinical application. Clinical phenotypes such as supine OSA has been the feature of other recent comprehensive reviews and research articles that eloquently highlight the therapeutic potential of positional therapy and how changes in body position alter the phenotypic traits that cause OSA (e.g. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - June 24, 2017 Category: Sleep Medicine Authors: Danny J. Eckert Tags: Commentary Source Type: research

Incidence of narcolepsy after H1N1 influenza and vaccinations: systematic review and meta-analysis
An increased incidence of narcolepsy was seen in many countries after the pandemic H1N1 influenza vaccination campaign in 2009-2010. The H1N1 vaccine - narcolepsy connection is based on observational studies that are prone to various biases, e.g. confounding by H1N1 infection, and ascertainment, recall and selection biases. A direct pathogenic link has, however, remained elusive. We conducted a systematic review and meta-analysis to analyze the magnitude of H1N1 vaccination related risk and to examine if there was any association with H1N1 infection itself. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - June 20, 2017 Category: Sleep Medicine Authors: Tomi Sarkanen, Anniina Alakuijala, Yves Dauvilliers, Markku Partinen Tags: Clinical Review Source Type: research

Complementary and alternative therapies for restless legs syndrome: An evidence-based systematic review
Restless legs syndrome (RLS) is defined as an irresistible urge to move the legs, which is usually accompanied by paresthesias or dysesthesias at least twice weekly, and affects 2% –4% of adults in Europe and North America. This systematic review assesses the current complementary and alternative options for RLS and the potential benefits of those treatments on sleep quality, mood disorder, and quality of life. A systematic search of the PubMed, Embase, Cochrane, and Web of Science databases was conducted. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - June 19, 2017 Category: Sleep Medicine Authors: Xiao-Min Xu, Yang Liu, Shi-Yu Jia, Mei-Xue Dong, Du Cao, You-Dong Wei Tags: Clinical Review Source Type: research

Complementary and Alternative Therapies for Restless Leg Syndrome: An Evidence-Based Systematic Review
Restless leg syndrome (RLS) is defined as an irresistible urge to move the legs, which is usually accompanied by paresthesias or dysesthesias, and affects 2% to 4% of adults in Europe and North America at least twice weekly. This systematic review assesses the current complementary and alternative options for RLS and the potential benefits of those treatments on sleep quality, mood disorder, and quality of life. A systematic search of the PubMed, Embase, Cochrane, and Web of Science databases was conducted. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - June 19, 2017 Category: Sleep Medicine Authors: Xiao-Min Xu, Yang Liu, Si-Yu Jia, Mei-Xue Dong, Du Cao, You-Dong Wei Source Type: research

Does anaesthesia stop the clock?
Anyone who has undergone general anaesthesia (GA) remembers the strange state of disorientation lasting for quite some time after waking up. Until recently, the idea that one ’s biological clock had just “paused” for a few hours was not a concept that was considered to explain (part of) this discombobulation. Yet it seems that when we go into the operating room, we come out in another time zone, or rather, time stands still: in other words, GA induces jet-lag. Post -operative recovery may be hindered by circadian disruption and the resulting sleep disturbances, and may also impair mood, alertness, cognitive performan...
Source: Sleep Medicine Reviews - June 16, 2017 Category: Sleep Medicine Authors: Anna Wirz-Justice, Miriam Frank Source Type: research

Sleep quality during pregnancy: A meta-analysis
Women ’s sleep quality has been reported to change during pregnancy; prevalence estimates of poor sleep quality during pregnancy vary widely. To further understand the observed variation of findings, we conducted a meta-analysis to quantify the prevalence of poor sleep quality during pregnancy. Articles (N = 24) that reported prevalence of poor sleep quality as captured by the Pittsburgh sleep quality index (PSQI) ≥ 5 were included, with a total of 11,002 participants contributing data. PubMed, PsycINFO, and Web of Science databases were systematically searched. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - June 14, 2017 Category: Sleep Medicine Authors: Ivan D. Sedov, Emily E. Cameron, Sheri Madigan, Lianne M. Tomfohr-Madsen Source Type: research

The influence of antidepressants on restless legs syndrome and periodic limb movements: A systematic review
Restless legs syndrome is commonly co-morbid with medical conditions that are treated with antidepressant medications, such as depression, anxiety, fibromyalgia, and chronic insomnia disorder. Evidence from case reports and cross-sectional studies suggests that antidepressants may induce or worsen restless legs syndrome and increase periodic limb movements. We undertook a systematic review of the literature to identify and collate all prospective studies that measured restless legs syndrome symptoms and/or periodic limb movements following the introduction of an antidepressant. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - June 14, 2017 Category: Sleep Medicine Authors: Bhanu Prakash Kolla, Meghna P. Mansukhani, J. Michael Bostwick Tags: Clinical Review Source Type: research

Prevalence of adenoid hypertrophy: a systematic review and meta-analysis
The purpose of our review was to synthesize the existing literature about the prevalence of adenoid hypertrophy in children and adolescents confirmed by the reference standard – the nasoendoscopy. Six electronic databases and grey literature were searched. Studies were included if they reported the prevalence of adenoid hypertrophy confirmed via nasoendoscopy. Studies involving participants with associated comorbidities, fully diagnosed sleep apnea in their sample were excluded. The MAStARI tool assessed the potential risk of bias (RoB) among the studies, while the GRADE approach determined the level of evidence. (Source...
Source: Sleep Medicine Reviews - June 13, 2017 Category: Sleep Medicine Authors: Lara Pereira, John Monyror, Fabiana T. Almeida, Fernanda R. Almeida, Eliete Guerra, Carlos Flores-Mir, Camila Pach êco-Pereira Tags: Clinical Review Source Type: research

A systematic review of variables associated with sleep paralysis
Sleep paralysis is a relatively common but under-researched phenomenon. While the causes are unknown, a number of studies have investigated potential risk factors. In this article, we conducted a systematic review on the available literature regarding variables associated with both the frequency and intensity of sleep paralysis episodes. A total of 42 studies met the inclusion criteria. For each study, sample size, study site, sex and age of participants, sleep paralysis measure, and results of analyses looking at the relationship(s) between sleep paralysis and associated variable(s) were extracted. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - June 7, 2017 Category: Sleep Medicine Authors: Dan Denis, Christopher C. French, Alice M. Gregory Tags: Clinical Review Source Type: research

Diseases of the retina and the optic nerve associated with obstructive sleep apnea
The objective of this review is to synthetize the possible vascular disorders of the retina and the optic nerve associated with sleep apnea patients and to discuss the underlying pathophysiological hypotheses. Main mechanisms involved in the ocular complications of OSA are related to intermittent hypoxia, sympathetic system activation, oxidant stress, and deleterious effects of endothelin 1 (ET-1). (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - May 29, 2017 Category: Sleep Medicine Authors: Marielle Mentek, Florent Aptel, Diane Godin-Ribuot, Renaud Tamisier, Jean-Louis Pepin, Christophe Chiquet Tags: Clinical Review Source Type: research

Positional patients (PP) and Non Positional patients (NPP) are two dominant phenotypes that should be included in the phenotypic approaches to Obstructive Sleep Apnea
We have read with interest the important manuscript of Eckert DJ: “Phenotypic approaches to obstructive sleep apnea – New pathways for targeted therapy”1. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - May 27, 2017 Category: Sleep Medicine Authors: Arie Oksenberg, Natan Gadoth Source Type: research

The role of sleep in regulating structural plasticity and synaptic strength: Implications for memory and cognitive function
Dendritic spines are the major sites of synaptic transmission in the central nervous system. Alterations in the strength of synaptic connections directly affect the neuronal communication, which is crucial for brain function as well as the processing and storage of information. Sleep and sleep loss bidirectionally alter structural plasticity, by affecting spine numbers and morphology, which ultimately can affect the functional output of the brain in terms of alertness, cognition, and mood. Experimental data from studies in rodents suggest that sleep deprivation may impact structural plasticity in different ways. (Source: S...
Source: Sleep Medicine Reviews - May 18, 2017 Category: Sleep Medicine Authors: Frank Raven, Eddy A. Van der Zee, Peter Meerlo, Robbert Havekes Tags: Physiological Review Source Type: research