Editorial Board
(Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - September 8, 2018 Category: Sleep Medicine Source Type: research

The Balance of Sleep: Role of the Vestibular Sensory System
The vestibular system encodes linear and angular head motion supporting numerous functions from gaze stabilization and postural control, to high-level cortical functions involving spatial cognition, including self-body perception, verticality perception, orientation, navigation and spatial memory. At the brainstem and mesencephalic levels, the vestibular organs also influence postural blood pressure regulation, bone density and muscle composition via specific vestibulo-sympathetic efferences and have been shown to act as a powerful synchronizer of circadian rhythms. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - September 8, 2018 Category: Sleep Medicine Authors: Stephane Besnard, Brahim Tighilet, Christian Chabbert, Martin Hitier, Joseph Toulouse, Anne Legall, Marie-Laure Machado, Paul F. Smith Tags: Clinical Review Source Type: research

Obstructive Sleep Apnea and the Metabolic Syndrome: The Road to Clinically-Meaningful Phenotyping, Improved Prognosis, and Personalized Treatment
Obstructive sleep apnea (OSA) is an increasingly prevalent sleep disorder characterized by upper airway obstruction during sleep, resulting in breathing pauses, intermittent hypoxia, and fragmented sleep. In parallel, the constellation of adverse health outcomes associated with prolonged obesity, such as insulin resistance, elevated blood pressure, triglycerides, and reduced high-density lipoprotein cholesterol – termed metabolic syndrome –raises the risk of cardiovascular morbidity and mortality, type 2 diabetes, and all-cause mortality. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - September 3, 2018 Category: Sleep Medicine Authors: Jordan Gaines, Alexandros N. Vgontzas, Julio Fernandez-Mendoza, Edward O. Bixler Tags: Clinical Review Source Type: research

Response to Letter to Editor “Optical coherence tomography (OCT) findings in obstructive sleep apnea“ by Piotr Kanclerz
We thank the reader for his comments concerning our review on obstructive sleep apnea syndrome (OSAS) and the eye (especially the retina and the optic nerve). Piotr Kanclerz reviewed the studies reporting the OCT findings of the optic nerve in OSAS subjects. Most particularly, the authors cited the following reference1 “Grzybowski A, Ascaso FJ, Mateo J, Cabezón L, Casas P. Other Neurological Disorders: Migraine, Neurosarcoidosis, Schizophrenia, Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS). (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - August 31, 2018 Category: Sleep Medicine Authors: Marielle Mentek, Florent Aptel, Diane Godin-Ribuot, Renaud Tamisier, Jean-Louis Pepin, Christophe Chiquet Tags: Reply Source Type: research

Determining the likelihood that fatigue was present in a road accident: A theoretical review and suggested accident taxonomy
Estimates in developed countries of the extent to which fatigue contributes to road accidents range from as low as 5% to as high as 50% of all accidents. Compared with other causes of road accidents (e.g. speeding, drink-driving), the variability in these estimates is exceptionally high and may be indicative of the difficulty in determining the likelihood of fatigue as a cause of road accidents.This review compares differences in the way road accidents are classified as fatigue-related (or not) by expert panels and road safety regulators, highlighting conflicting conceptual approaches, lack of consistency, and the poor psy...
Source: Sleep Medicine Reviews - August 29, 2018 Category: Sleep Medicine Authors: Drew Dawson, Amy C. Reynolds, Hans P.A. Van Dongen, Matthew J.W. Thomas Tags: Theoretical Review Source Type: research

Optical coherence tomography (OCT) findings in obstructive sleep apnea
We have read the article by Mentek et al., however, we believe some discussion would be of benefit.1 The authors describe vascular disorders of the retina and the optic nerve in patients affected by obstructive sleep apnea (OSA). When reviewing results of eye tests of this disorder, it is necessary to mention that OSA itself presents alterations in particular ophthalmic examinations. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - August 29, 2018 Category: Sleep Medicine Authors: Piotr Kanclerz, Andrzej Grzybowski Tags: Letter to the editor Source Type: research

Brain structural and functional alterations in insomnia disorder: more “homogeneous” research is needed
The authors declare no potential conflicts of interest regarding the authorship and publication. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - August 26, 2018 Category: Sleep Medicine Authors: Hua Liu, HaiCun Shi, PingLei Pan Tags: Letter to the editor Source Type: research

Reply to Hua Liu, HaiCun Shi and PingLei Pan: Coordinate based meta-analyses in a medium sized literature: considerations, limitations and road ahead
We thank Liu and colleagues for their interest in and thoughtful comments on our neuroimaging meta-analysis on insomnia disorder (1). In their commentary, the authors highlight the conceptual and technical diversity among current neuroimaging approaches, including those that were integrated in our recent analysis. We completely concur with their summary on these differences, as indeed different modalities and analysis methods reveal different neurobiological features (2, 3). Therefore, we would like to focus on what we perceive as the critical question arising from this commentary, namely whether the findings obtained by t...
Source: Sleep Medicine Reviews - August 26, 2018 Category: Sleep Medicine Authors: Masoud Tahmasian, Khadijeh Noori, Fateme Samea, Mojtaba Zarei, Kai Spiegelhalder, Simon B. Eickhoff, Eus Van Someren, Habibolah Khazaie, Claudia R. Eickhoff Tags: Reply Source Type: research

Low-grade inflammation in the relationship between sleep disruption, dysfunctional adiposity, and cognitive decline in aging
Aging is characterized by a progressive increase in proinflammatory status. This state, known as inflammaging, has been associated with cognitive decline in normal and pathological aging. However, this relationship has been inconsistently reported, likely because it is conditioned by other factors also affected by the aging process. Sleep and adiposity are two factors in particular that show significant alterations with aging and have been related to both cognitive decline and inflammaging. Given the consequences this state also has for brain integrity and cognition, we discuss here evidence supporting the potential mediat...
Source: Sleep Medicine Reviews - August 16, 2018 Category: Sleep Medicine Authors: Mercedes Atienza, Jacob Ziontz, Jose L. Cantero Tags: Theoretical Review Source Type: research

Influence of sleep on developing brain functions and structures in children and adolescents: A systematic review
This systematic review examined the associations between sleep and brain functions and structures in children and adolescents aged 1 to 17 years. Included studies (n=24) were peer-reviewed and met the a priori determined population (apparently healthy children and adolescents aged 1 year to 17 years), intervention/exposure/comparator (various sleep characteristics including duration, architecture, quality, timing), and outcome criteria (brain functions and/or brain structures, excluding cognitive function outcomes). (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - August 14, 2018 Category: Sleep Medicine Authors: Caroline Dutil, Jeremy J. Walsh, Ryan B. Featherstone, Katie E. Gunnell, Mark S. Tremblay, Reut Gruber, Shelly K. Weiss, Kimberly A. Cote, Margaret Sampson, Jean-Philippe Chaput Tags: Clinical Review Source Type: research

Biomarkers of dementia in obstructive sleep apnea
Epidemiologic and mechanistic evidence is increasingly supporting the notion that obstructive sleep apnea is a risk factor for dementia. Hence, the identification of patients at risk of cognitive decline due to obstructive sleep apnea may significantly improve preventive strategies and treatment decision-making. Cerebrospinal fluid and blood biomarkers obtained through genomic, proteomic and metabolomic approaches are improving the ability to predict incident dementia. Therefore, fluid biomarkers have the potential to predict vulnerability to neurodegeneration in individuals with obstructive sleep apnea, as well as deepen ...
Source: Sleep Medicine Reviews - August 13, 2018 Category: Sleep Medicine Authors: Andr ée-Ann Baril, Julie Carrier, Alexandre Lafrenière, Simon Warby, Judes Poirier, Ricardo S. Osorio, Najib Ayas, Marie-Pierre Dubé, Dominique Petit, Nadia Gosselin, Canadian Sleep and Circadian Network Tags: Clinical Review Source Type: research

Linking Sleep Disturbance To Idiopathic Male Infertility
Recently published data suggests that male fertility has declined over the past four decades. The reasons for the decline are unclear with up to 50% of cases of male infertility remaining unexplained (idiopathic male infertility). Whilst environmental factors and rising rates of obesity have been implicated, there is now growing evidence that sleep disturbance may be an independent causative factor. Indeed, the prevalence of sleep disturbance appears to be increasing in parallel with deterioration in population sperm quality, a commonly used surrogate marker of male fertility. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - August 3, 2018 Category: Sleep Medicine Authors: Gaurie Palnitkar, Craig L. Phillips, Camilla M. Hoyos, Anthony J. Marren, Mark C. Bowman, Brendon J. Yee Tags: Theoretical Review Source Type: research

Targeting volume overload and overnight rostral fluid shift: a new perspective to treat sleep apnea
Sleep apnea is a common condition associated with increased morbidity and mortality. Continuous positive airway pressure and oral appliances are efficient for treating sleep apnea; however, they are often poorly tolerated. Therefore, alternative therapies are needed. Overnight rostral fluid shift has been implicated in the pathogenesis of sleep apnea, particularly in conditions associated with fluid overload. Fluid shift predisposes to both obstructive and central sleep apnea, with the type of sleep apnea being related to whether the fluid shifts from the legs into the neck or chest, respectively. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - August 3, 2018 Category: Sleep Medicine Authors: E. Perger, E.M. Jutant, S. Redolfi Tags: Clinical Review Source Type: research

Climate Change and Sleep: A Systematic Review of the Literature and Conceptual Framework
From disaster related stress causing insomnia, to poor air quality causing sleep related breathing problems, climate change poses a potentially serious threat to human sleep. We conducted a systematic review evaluating the relationship between climate change and human sleep in the PubMed, Scopus, and Cochrane databases from 1980 through 2017 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion criteria included epidemiologic studies published in English that reported observational population data on human sleep and its relationship to climate change, temperature, e...
Source: Sleep Medicine Reviews - August 3, 2018 Category: Sleep Medicine Authors: Daniel I. Rifkin, Michael W. Long, Melissa J. Perry Tags: Clinical Review Source Type: research

How does sleep restriction therapy for insomnia work? A systematic review of mechanistic evidence and the introduction of the Triple-R model
For over 30 years sleep restriction therapy (SRT) has been used to treat insomnia but we know very little about how this therapy exerts its effects. When SRT was first described, it was hypothesised to treat insomnia by addressing four key factors: strengthening homeostatic sleep pressure, inhibiting perpetuating practices (excessive time in bed), attenuating hyperarousal and tightening regulatory control of sleep by the endogenous circadian pacemaker. We conducted a systematic literature review in search of evidence for these putative mechanisms-of-action. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - July 15, 2018 Category: Sleep Medicine Authors: Leonie F. Maurer, Colin A. Espie, Simon D. Kyle Tags: Clinical Review Source Type: research