Progress in Retinal and Eye Research 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Stromal keratophakia: Corneal inlay implantation
Publication date: Available online 4 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Andri K. Riau, Yu-Chi Liu, Gary H.F. Yam, Jodhbir S. MehtaAbstractStromal keratophakia was first performed by José Ignacio Barraquer in the 1960s. The refractive lamellar keratoplasty technique was intensely pursued in the 1980s as a method to alter corneal refractive power. However, because sculpting of the donor stromal lenticule and lamellar keratectomy of the recipient's cornea were performed with a mechanical microkeratome, the quality of the cut was inconsistent. Consequently, the refractive outcomes of the lent...
Source: Progress in Retinal and Eye Research - September 8, 2019 Category: Opthalmology Source Type: research
Innate immune response in retinal homeostasis and inflammatory disorders
Publication date: Available online 7 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Yusuke Murakami, Keijiro Ishikawa, Shintaro Nakao, Koh-Hei SonodaAbstractInnate immune cells such as neutrophils, monocyte-macrophages and microglial cells are pivotal for the health and disease of the retina. For the maintenance of retinal homeostasis, these cells and immunosuppressive molecules in the eye actively regulate the induction and the expression of inflammation in order to prevent excessive activation and subsequent tissue damage. In the disease context, these regulatory mechanisms are modulated genetically...
Source: Progress in Retinal and Eye Research - September 8, 2019 Category: Opthalmology Source Type: research
Diurnal rodents as pertinent animal models of human retinal physiology and pathology
Publication date: Available online 6 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Daniela M. Verra, Benjamin S. Sajdak, Dana K. Merriman, David HicksAbstractThis presentation will survey the retinal architecture, advantages, and limitations of several lesser-known rodent species that provide a useful diurnal complement to rats and mice. These diurnal rodents also possess unusually cone-rich photoreceptor mosaics that facilitate the study of cone cells and pathways. Species to be presented include principally the Sudanian Unstriped Grass Rat and Nile Rat (Arvicanthis spp.), the Fat Sand Rat (Psammomy...
Source: Progress in Retinal and Eye Research - September 8, 2019 Category: Opthalmology Source Type: research
Retinal stem cell transplantation: Balancing safety and potential
Publication date: Available online 5 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Mandeep S. Singh, Susanna S. Park, Thomas A. Albini, M. Valeria Canto-Soler, Henry Klassen, Robert E. MacLaren, Masayo Takahashi, Aaron Nagiel, Steven D. Schwartz, Kapil BhartiAbstractStem cell transplantation holds great promise as a potential treatment for currently incurable retinal degenerative diseases that cause poor vision and blindness. Recently, safety data have emerged from several Phase I/II clinical trials of retinal stem cell transplantation. These clinical trials, usually run in partnership with academic ...
Source: Progress in Retinal and Eye Research - September 6, 2019 Category: Opthalmology Source Type: research
Membrane-associated mucins of the ocular surface new genes, new protein functions and new biological roles in human and mouse
Publication date: Available online 4 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): M.Elizabeth Fini, Shinwu Jeong, Haiyan Gong, Rafael Martinez-Carrasco, Nora M.V. Laver, Minako Hijikata, Naoto Keicho, Pablo ArgüesoAbstractThe mucosal glycocalyx of the ocular surface constitutes the point of interaction between the tear film and the apical epithelial cells. Membrane-associated mucins (MAMs) are the defining molecules of the glycocalyx in all mucosal epithelia. Long recognized for their biophysical properties of hydration, lubrication, anti-adhesion and repulsion, MAMs maintain the wet ocular surface...
Source: Progress in Retinal and Eye Research - September 5, 2019 Category: Opthalmology Source Type: research
Stromal keratophakia
Publication date: Available online 4 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Andri K. Riau, Yu-Chi Liu, Gary H.F. Yam, Jodhbir S. MehtaAbstractStromal keratophakia was first performed by José Ignacio Barraquer in the 1960s. The refractive lamellar keratoplasty technique was intensely pursued in the 1980s as a method to alter corneal refractive power. However, because sculpting of the donor stromal lenticule and lamellar keratectomy of the recipient's cornea were performed with a mechanical microkeratome, the quality of the cut was poor and inconsistent. Consequently, the refractive outcomes of...
Source: Progress in Retinal and Eye Research - September 4, 2019 Category: Opthalmology Source Type: research
Understanding the complexity of the matrix metalloproteinase system and its relevance to age-related diseases: Age-related macular degeneration and Alzheimer's disease
Publication date: Available online 29 August 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Ali A. Hussain, Yunhee Lee, John MarshallAbstractExtracellular matrices (ECMs) are maintained by tightly coupled processes of continuous synthesis and degradation. The degradative arm is mediated by a family of proteolytic enzymes called the matrix metalloproteinases (MMPs). These enzymes are released as latent proteins (pro-MMPs) and on activation are capable of degrading most components of an ECM. Activity of these enzymes is checked by the presence of tissue inhibitors of MMPs (TIMPs) and current opinion holds that th...
Source: Progress in Retinal and Eye Research - August 30, 2019 Category: Opthalmology Source Type: research
Lessons learned from quantitative fundus autofluorescence
Publication date: Available online 28 August 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Janet R. Sparrow, Tobias Duncker, Kaspar Schuerch, Maarjaliis Paavo, Jose Ronaldo Lima de CarvalhoAbstractQuantitative fundus autofluorescence (qAF) is an approach that is built on a confocal scanning laser platform and used to measure the intensity of the inherent autofluorescence of retina elicited by short-wavelength (488 nm) excitation. Being non-invasive, qAF does not interrupt tissue architecture, thus allowing for structural correlations. The spectral features, cellular origin and topographic distribution of the...
Source: Progress in Retinal and Eye Research - August 28, 2019 Category: Opthalmology Source Type: research
Scleral structure and biomechanics
Publication date: Available online 11 August 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Craig Boote, Ian A. Sigal, Rafael Grytz, Yi Hua, Thao D. Nguyen, Michael J.A. GirardAbstractAs the eye's main load-bearing connective tissue, the sclera is centrally important to vision. In addition to cooperatively maintaining refractive status with the cornea, the sclera must also provide stable mechanical support to vulnerable internal ocular structures such as the retina and optic nerve head. Moreover, it must achieve this under complex, dynamic loading conditions imposed by eye movements and fluid pressures. Recent ...
Source: Progress in Retinal and Eye Research - August 13, 2019 Category: Opthalmology Source Type: research
Editorial Board
Publication date: July 2019Source: Progress in Retinal and Eye Research, Volume 71Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - August 6, 2019 Category: Opthalmology Source Type: research
Cellular mechanisms of hereditary photoreceptor degeneration – Focus on cGMP
Publication date: Available online 30 July 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Michael Power, Soumyaparna Das, Karin Schütze, Valeria Marigo, Per Ekström, François Paquet-DurandAbstractThe cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood, a problem that is exacerbated by the enormous genetic heterogeneity of this disease group. However, the last decade has yielded a wealth of new knowledge on degenerative pathways and their diversity. Notably, a central role of cGMP-signalling has surfaced for photoreceptor cell death triggered by a subset of disease...
Source: Progress in Retinal and Eye Research - August 1, 2019 Category: Opthalmology Source Type: research
Persistent remodeling and neurodegeneration in late-stage retinal degeneration
Publication date: Available online 26 July 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Rebecca L. Pfeiffer, Bryan William Jones, Robert E. MarcAbstractRetinal remodeling is a progressive series of negative plasticity revisions that arise from retinal degeneration, and are seen in retinitis pigmentosa, age-related macular degeneration and other forms of retinal disease. These processes occur regardless of the precipitating event leading to degeneration. Retinal remodeling then culminates in a late-stage neurodegeneration that is indistinguishable from progressive central nervous system (CNS) proteinopathies. ...
Source: Progress in Retinal and Eye Research - July 26, 2019 Category: Opthalmology Source Type: research
Central serous chorioretinopathy: Towards an evidence-based treatment guideline
Publication date: Available online 15 July 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Thomas J. van Rijssen, Elon H.C. van Dijk, Suzanne Yzer, Kyoko Ohno-Matsui, Jan E.E. Keunen, Reinier O. Schlingemann, Sobha Sivaprasad, Giuseppe Querques, Susan M. Downes, Sascha Fauser, Carel B. Hoyng, Felice Cardillo Piccolino, Jay K. Chhablani, Timothy Y.Y. Lai, Andrew J. Lotery, Michael Larsen, Frank G. Holz, K. Bailey Freund, Lawrence A. Yannuzzi, Camiel J.F. BoonAbstractCentral serous chorioretinopathy (CSC) is a common cause of central vision loss, primarily affecting men 20–60 years of age. To date, no consensus ...
Source: Progress in Retinal and Eye Research - July 17, 2019 Category: Opthalmology Source Type: research
Axon injury signaling and compartmentalized injury response in glaucoma
Publication date: Available online 10 July 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Stephanie B. Syc-Mazurek, Richard T. LibbyAbstractAxonal degeneration is an active, highly controlled process that contributes to beneficial processes, such as developmental pruning, but also to neurodegeneration. In glaucoma, ocular hypertension leads to vision loss by killing the output neurons of the retina, the retinal ganglion cells (RGC). Multiple processes have been proposed to contribute to and/or mediate axonal injury in glaucoma including: neuroinflammation, loss of neurotropic factors, dysregulation of the neuro...
Source: Progress in Retinal and Eye Research - July 10, 2019 Category: Opthalmology Source Type: research
Immune reactions after modern lamellar (DALK, DSAEK, DMEK) versus conventional penetrating corneal transplantation
Publication date: Available online 3 July 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Deniz Hos, Mario Matthaei, Felix Bock, Kazuichi Maruyama, Maria Notara, Thomas Clahsen, Yanhong Hou, Viet Nhat Hung Le, Ann-Charlott Salabarria, Jens Horstmann, Bjoern O. Bachmann, Claus CursiefenAbstractIn the past decade, novel lamellar keratoplasty techniques such as Deep Anterior Lamellar Keratoplasty (DALK) for anterior keratoplasty and Descemet stripping automated endothelial keratoplasty (DSAEK)/Descemet membrane endothelial keratoplasty (DMEK) for posterior keratoplasty have been developed. DALK eliminates the possi...
Source: Progress in Retinal and Eye Research - July 4, 2019 Category: Opthalmology Source Type: research
