Progress in Retinal and Eye Research 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Neuropathic keratopathy
Publication date: Available online 23 April 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Harminder S. Dua, Dalia G. Said, Elisabeth M. Messmer, Maurizio Rolando, Jose M. Benitez-del-Castillo, Parwez N. Hossain, Alex J. Shortt, Gerd Gerling, Mario Nubile, Francisco C. Figueiredo, Saaeha Rauz, Leonardo Mastropasqua, Paolo Rama, Christophe BaudouinAbstractNeurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. Sensory nerves serve nociceptor and trophic...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Zika and the Eye: Pieces of a Puzzle
Publication date: Available online 24 April 2018Source: Progress in Retinal and Eye ResearchAuthor(s): João Rafael de Oliveira Dias, Camila V. Ventura, Bruno de Paula Freitas, Juliana Prazeres, Liana O. Ventura, Vasco Bravo-Filho, Tomas Aleman, Albert Icksang Ko, Andréa Zin, Rubens Belfort, Mauricio Maia, the Zika Virus Study GroupAbstractZika virus (ZIKV) is an arbovirus mainly transmitted to humans by mosquitoes from Aedes genus. Other ways of transmission include the perinatal and sexual routes, blood transfusion, and laboratory exposure. Although the first human cases were registered in 1952 in African countries, out...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Evolution of the vertebrate corneal stroma
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): Elena Koudouna, Moritz Winkler, Eric Mikula, Tibor Juhasz, Donald J. Brown, James V. JesterAbstractAlthough the cornea is the major refractive element of the eye, the mechanisms controlling corneal shape and hence visual acuity remain unknown. To begin to address this question we have used multiphoton, non-linear optical microscopy to image second harmonic generated signals (SHG) from collagen to characterize the evolutionary and structural changes that occur in the collagen architecture of the corneal stroma. Our studies show that ...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Cataract, phacoemulsification and intraocular pressure: Is the anterior segment anatomy the missing piece of the puzzle?
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): Marisse Masis Solano, Shan C. LinAbstractCataract extraction is a safe and effective surgery that has a lowering effect on the intraocular pressure. The specific mechanisms for this effect are still unclear. A direct inflammatory effect on the trabecular meshwork, alteration of the blood aqueous barrier, changes in the ciliary body and mechanical changes of the anterior segment anatomy are the key to understand cataract surgery and it's effects on aqueous humor dynamics. Additionally, with the advent of AS OCT, changes in the anteri...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Neural control of choroidal blood flow
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): Anton Reiner, Malinda E.C. Fitzgerald, Nobel Del Mar, Chunyan LiAbstractThe choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory nerve fibers that regulate choroidal blood flow in birds and mammals, and presumably other vertebrate classes as well. The parasympathetic innervation has been shown to vasodilate and increase choroidal blood flow, the sympathetic input has been shown to vasoconstrict and decrease choroidal blood flow, and the sensory input has been shown to both convey pain and thermal infor...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Epigenetics, microbiota, and intraocular inflammation: New paradigms of immune regulation in the eye
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): Xiaofeng Wen, Xiao Hu, Li Miao, Xiaofei Ge, Yuhua Deng, Paul W. Bible, Lai WeiAbstractSight threatening immune responses that damage the eye characterize intraocular inflammatory diseases. These diseases including uveitis and age-related macular degeneration are worryingly common and quality of life shattering. Genetic studies in past decades significantly advanced our understanding of the etiology of these devastating diseases. Unfortunately, patient genetics alone failed to adequately explain disease origin, susceptibility, and pr...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): Jean-Sébastien Joyal, Marin L. Gantner, Lois E.H. Smith (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
The pupillary light responses of animals; a review of their distribution, dynamics, mechanisms and functions
Publication date: Available online 1 May 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Ronald H. DouglasAbstractThe timecourse and extent of changes in pupil area in response to light are reviewed in all classes of vertebrate and cephalopods. Although the speed and extent of these responses vary, most species, except the majority of teleost fish, show extensive changes in pupil area related to light exposure. The neuromuscular pathways underlying light-evoked pupil constriction are described and found to be relatively conserved, although the precise autonomic mechanisms differ somewhat between species. In mamm...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Editorial Board
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Optical coherence tomography angiography
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): Richard F. Spaide, James G. Fujimoto, Nadia K. Waheed, Srinivas R. Sadda, Giovanni StaurenghiAbstractOptical coherence tomography (OCT) was one of the biggest advances in ophthalmic imaging. Building on that platform, OCT angiography (OCTA) provides depth resolved images of blood flow in the retina and choroid with levels of detail far exceeding that obtained with older forms of imaging. This new modality is challenging because of the need for new equipment and processing techniques, current limitations of imaging capability, and ra...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Basal Tear Osmolarity as a metric to estimate body hydration and dry eye severity
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): C. Willshire, A.J. Bron, E.A. Gaffney, E. Ian PearceAbstractThe osmolarities of various bodily fluids, including tears, saliva and urine, have been used as indices of plasma osmolality, a measure of body hydration, while tear osmolarity is used routinely in dry eye diagnosis, the degree of tear hyperosmolarity providing an index of disease severity. Systemic dehydration, due to inadequate water intake or excessive water loss is common in the elderly population, has a high morbidity and may cause loss of life. Its diagnosis is often ...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
A new perspective on lipid research in age-related macular degeneration
Publication date: Available online 4 May 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Elisabeth M. van Leeuwen, Eszter Emri, Benedicte M.J. Merle, Johanna M. Colijn, Eveline Kersten, Audrey Cougnard-Gregoire, Sascha Dammeier, Magda Meester-Smoor, Frances M. Pool, Eiko K. de Jong, Cécile Delcourt, Eduardo Rodrigez-Bocanegra, Marc Biarnés, Philip J. Luthert, Marius Ueffing, Caroline C.W. Klaver, Everson Nogoceke, Anneke I. den Hollander, Imre LengyelAbstractThere is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoprot...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
The Drosophila light-activated TRP and TRPL channels - Targets of the phosphoinositide signaling cascade
Publication date: Available online 5 May 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Ben Katz, Baruch MinkeAbstractThe Drosophila light-activated Transient Receptor Potential (TRP) channel is the founding member of a large and diverse family of channel proteins. It is now established that TRP channels are evolutionarily conserved and are found in many organisms and tissues. This review outlines the progress made in our understanding of Drosophila phototransduction with a focus on the light sensitive TRP channels. The visual system of Drosophila has remarkable capabilities, such as single photon sensitivity, ...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors
Publication date: Available online 6 June 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Frans Vinberg, Jeannie Chen, Vladimir J. KefalovAbstractCalcium plays important roles in the function and survival of rod and cone photoreceptor cells. Rapid regulation of calcium in the outer segments of photoreceptors is required for the modulation of phototransduction that drives the termination of the flash response as well as light adaptation in rods and cones. On a slower time scale, maintaining proper calcium homeostasis is critical for the health and survival of photoreceptors. Decades of work have established that ...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
NAD+ and sirtuins in retinal degenerative diseases: A look at future therapies
Publication date: Available online 12 June 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Jonathan B. Lin, Rajendra S. ApteAbstractRetinal degenerative diseases are a major cause of morbidity in modern society because visual impairment significantly decreases the quality of life of patients. A significant challenge in treating retinal degenerative diseases is their genetic and phenotypic heterogeneity. However, despite this diversity, many of these diseases share a common endpoint involving death of light-sensitive photoreceptors. Identifying common pathogenic mechanisms that contribute to photoreceptor death i...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
