Progress in Retinal and Eye Research 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Epigenetics, microbiota, and intraocular inflammation: New paradigms of immune regulation in the eye
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): Xiaofeng Wen, Xiao Hu, Li Miao, Xiaofei Ge, Yuhua Deng, Paul W. Bible, Lai WeiAbstractSight threatening immune responses that damage the eye characterize intraocular inflammatory diseases. These diseases including uveitis and age-related macular degeneration are worryingly common and quality of life shattering. Genetic studies in past decades significantly advanced our understanding of the etiology of these devastating diseases. Unfortunately, patient genetics alone failed to adequately explain disease origin, susceptibility, and pr...
Source: Progress in Retinal and Eye Research - July 10, 2018 Category: Opthalmology Source Type: research
Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): Jean-Sébastien Joyal, Marin L. Gantner, Lois E.H. Smith (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - July 10, 2018 Category: Opthalmology Source Type: research
The pupillary light responses of animals; a review of their distribution, dynamics, mechanisms and functions
Publication date: Available online 1 May 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Ronald H. DouglasAbstractThe timecourse and extent of changes in pupil area in response to light are reviewed in all classes of vertebrate and cephalopods. Although the speed and extent of these responses vary, most species, except the majority of teleost fish, show extensive changes in pupil area related to light exposure. The neuromuscular pathways underlying light-evoked pupil constriction are described and found to be relatively conserved, although the precise autonomic mechanisms differ somewhat between species. In mamm...
Source: Progress in Retinal and Eye Research - July 10, 2018 Category: Opthalmology Source Type: research
Editorial Board
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - July 10, 2018 Category: Opthalmology Source Type: research
Optical coherence tomography angiography
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): Richard F. Spaide, James G. Fujimoto, Nadia K. Waheed, Srinivas R. Sadda, Giovanni StaurenghiAbstractOptical coherence tomography (OCT) was one of the biggest advances in ophthalmic imaging. Building on that platform, OCT angiography (OCTA) provides depth resolved images of blood flow in the retina and choroid with levels of detail far exceeding that obtained with older forms of imaging. This new modality is challenging because of the need for new equipment and processing techniques, current limitations of imaging capability, and ra...
Source: Progress in Retinal and Eye Research - July 10, 2018 Category: Opthalmology Source Type: research
Basal Tear Osmolarity as a metric to estimate body hydration and dry eye severity
Publication date: May 2018Source: Progress in Retinal and Eye Research, Volume 64Author(s): C. Willshire, A.J. Bron, E.A. Gaffney, E. Ian PearceAbstractThe osmolarities of various bodily fluids, including tears, saliva and urine, have been used as indices of plasma osmolality, a measure of body hydration, while tear osmolarity is used routinely in dry eye diagnosis, the degree of tear hyperosmolarity providing an index of disease severity. Systemic dehydration, due to inadequate water intake or excessive water loss is common in the elderly population, has a high morbidity and may cause loss of life. Its diagnosis is often ...
Source: Progress in Retinal and Eye Research - July 10, 2018 Category: Opthalmology Source Type: research
A new perspective on lipid research in age-related macular degeneration
Publication date: Available online 4 May 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Elisabeth M. van Leeuwen, Eszter Emri, Benedicte M.J. Merle, Johanna M. Colijn, Eveline Kersten, Audrey Cougnard-Gregoire, Sascha Dammeier, Magda Meester-Smoor, Frances M. Pool, Eiko K. de Jong, Cécile Delcourt, Eduardo Rodrigez-Bocanegra, Marc Biarnés, Philip J. Luthert, Marius Ueffing, Caroline C.W. Klaver, Everson Nogoceke, Anneke I. den Hollander, Imre LengyelAbstractThere is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoprot...
Source: Progress in Retinal and Eye Research - July 10, 2018 Category: Opthalmology Source Type: research
The Drosophila light-activated TRP and TRPL channels - Targets of the phosphoinositide signaling cascade
Publication date: Available online 5 May 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Ben Katz, Baruch MinkeAbstractThe Drosophila light-activated Transient Receptor Potential (TRP) channel is the founding member of a large and diverse family of channel proteins. It is now established that TRP channels are evolutionarily conserved and are found in many organisms and tissues. This review outlines the progress made in our understanding of Drosophila phototransduction with a focus on the light sensitive TRP channels. The visual system of Drosophila has remarkable capabilities, such as single photon sensitivity, ...
Source: Progress in Retinal and Eye Research - July 10, 2018 Category: Opthalmology Source Type: research
Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors
Publication date: Available online 6 June 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Frans Vinberg, Jeannie Chen, Vladimir J. KefalovAbstractCalcium plays important roles in the function and survival of rod and cone photoreceptor cells. Rapid regulation of calcium in the outer segments of photoreceptors is required for the modulation of phototransduction that drives the termination of the flash response as well as light adaptation in rods and cones. On a slower time scale, maintaining proper calcium homeostasis is critical for the health and survival of photoreceptors. Decades of work have established that ...
Source: Progress in Retinal and Eye Research - July 10, 2018 Category: Opthalmology Source Type: research
NAD+ and sirtuins in retinal degenerative diseases: A look at future therapies
Publication date: Available online 12 June 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Jonathan B. Lin, Rajendra S. ApteAbstractRetinal degenerative diseases are a major cause of morbidity in modern society because visual impairment significantly decreases the quality of life of patients. A significant challenge in treating retinal degenerative diseases is their genetic and phenotypic heterogeneity. However, despite this diversity, many of these diseases share a common endpoint involving death of light-sensitive photoreceptors. Identifying common pathogenic mechanisms that contribute to photoreceptor death i...
Source: Progress in Retinal and Eye Research - July 10, 2018 Category: Opthalmology Source Type: research
The dynamic receptive fields of retinal ganglion cells
Publication date: Available online 23 June 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Sophia Wienbar, Gregory W. SchwartzAbstractRetinal ganglion cells (RGCs) were one of the first classes of sensory neurons to be described in terms of a receptive field (RF). Over the last six decades, our understanding of the diversity of RGC types and the nuances of their response properties has grown exponentially. We will review the current understanding of RGC RFs mostly from studies in mammals, but including work from other vertebrates as well. We will argue for a new paradigm that embraces the fluidity of RGC RFs wit...
Source: Progress in Retinal and Eye Research - July 10, 2018 Category: Opthalmology Source Type: research
Real-world outcomes in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor inhibitors
We describe the development of global registries, in particular the Fight Retinal Blindness! registry that originated in Australia, the United Kingdom AMD Electronic Medical Records User Group and the IRIS registry in the USA. Real-world observations relating to efficacy, safety and resource utilisation of intravitreal anti-VEGF therapy for neovascular AMD are then summarised. Novel observations that would have been challenging to identify in a clinical trial setting are then highlighted, including the risk of late disease reactivation, outcomes in second versus first treated eyes, and the increased risk of posterior capsu...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Personalised genome editing – The future for corneal dystrophies
Publication date: Available online 31 January 2018Source: Progress in Retinal and Eye ResearchAuthor(s): C.B. Tara Moore, Kathleen A. Christie, John Marshall, M. Andrew NesbitAbstractThe potential of personalised genome editing reaching the clinic has come to light due to advancements in the field of gene editing, namely the development of CRISPR/Cas9. The different mechanisms of repair used to resolve the double strand breaks (DSBs) mediated by Cas9 allow targeting of a wide range of disease causing mutations. Collectively, the corneal dystrophies offer an ideal platform for personalised genome editing; the majority of co...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
Neuroprotective strategies for retinal disease
Publication date: Available online 23 February 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Machelle T. Pardue, Rachael S. AllenAbstractDiseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of sight affects patient quality of life and puts an economic burden both on individuals and the greater healthcare system. Despite the urgent need for treatments, few effective options currently exist in the clinic. Here, we review research on promising neuroprotective strategies that promot...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
The immunopathogenesis of chronic and relapsing autoimmune uveitis – Lessons from experimental rat models
Publication date: Available online 27 February 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Maria Diedrichs-Möhring, Ulrike Kaufmann, Gerhild WildnerAbstractAutoimmune diseases usually follow a relapsing-remitting or a chronic progressive course. To understand the underlying immunopathogenesis we investigated experimental Lewis rat models displaying both disease types, which were only dependent on the autoantigen peptide used for immunization. Retinal S-Antigen-peptide PDSAg induces chronic, monophasic disease, whilst interphotoreceptor retinoid-binding protein (IRBP)-peptide R14 causes a spontaneously relap...
Source: Progress in Retinal and Eye Research - July 5, 2018 Category: Opthalmology Source Type: research
