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Myopic maculopathy: Current status and proposal for a new classification and grading system (ATN)
Publication date: Available online 1 November 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Jorge Ruiz-Medrano, Javier A. Montero, Ignacio Flores-Moreno, Luis Arias, Alfredo García-Layana, José M. Ruiz-MorenoAbstractMyopia is a highly frequent ocular disorder worldwide and pathologic myopia is the 4th most common cause of irreversible blindness in developed countries. Pathologic myopia is especially common in East Asian countries. Ocular alterations associated with pathologic myopia, especially those involving the macular area—defined as myopic maculopathy—are the leading causes of vision loss in patient...
Source: Progress in Retinal and Eye Research - November 2, 2018 Category: Opthalmology Source Type: research

The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases
Publication date: Available online 30 October 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Tine Van Bergen, Isabelle Etienne, Fiona Cunningham, Lieve Moons, Reinier O. Schlingemann, Jean H.M. Feyen, Alan StittAbstractPlacental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family. Upon binding to VEGF- and neuropilin-receptor sub-types, PlGF modulates a range of neural, glial and vascular cell responses that are distinct from VEGF-A. As PlGF expression is selectively associated with pathological angiogenesis and inflammation, its blockade does not affect the healthy vasculat...
Source: Progress in Retinal and Eye Research - October 30, 2018 Category: Opthalmology Source Type: research

ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function
Publication date: Available online 25 October 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Blake R. Hopiavuori, Robert E. Anderson, Martin-Paul AgbagaAbstractELOngation of Very Long chain fatty acids-4 (ELOVL4) is an elongase responsible for the biosynthesis of very long chain (VLC, ≥C28) saturated (VLC-SFA) and polyunsaturated (VLC-PUFA) fatty acids in brain, retina, skin, Meibomian glands, and testes. Fascinatingly, different mutations in this gene have been reported to cause vastly different phenotypes in humans. Heterozygous inheritance of seven different mutations in the coding sequence and 5’ untran...
Source: Progress in Retinal and Eye Research - October 26, 2018 Category: Opthalmology Source Type: research

Immune regulation in the aging retina
Publication date: Available online 20 October 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Mei Chen, Chang Luo, Jiawu Zhao, Gayathri Devarajan, Heping XuAbstractThe retina is an immune privileged tissue, which is protected from external and internal insults by its blood-retinal barriers and immune suppressive microenvironment. Apart from the avoidance and tolerance strategies, the retina is also protected by its own defense system, i.e., microglia and the complement system. The immune privilege and defense mechanisms work together to maintain retinal homeostasis. During aging, the retina is at an increased ri...
Source: Progress in Retinal and Eye Research - October 20, 2018 Category: Opthalmology Source Type: research

3D cell-laden polymers to release bioactive products in the eye
Publication date: Available online 18 October 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Gorka Orive, Edorta Santos-Vizcaino, Jose Luis Pedraz, Rosa Maria Hernandez, Julia E. Vela Ramirez, Alireza Dolatshahi-Pirouz, Ali Khademhosseini, Nicholas A. Peppas, Dwaine F. EmerichAbstractMillions of people worldwide suffer from debilitating, progressive, and often permanent loss of vision without any viable treatment options. The complex physiological barriers of the eye contribute to the difficulty in developing novel therapies by limiting our ability to deliver therapeutics in a sustained and controlled manner; e...
Source: Progress in Retinal and Eye Research - October 19, 2018 Category: Opthalmology Source Type: research

The clinical relevance of visualising the peripheral retina
Publication date: Available online 10 October 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Nicola Quinn, Lajos Csincsik, Erin Flynn, Christine Curcio, Szilard Kiss, SriniVas R. Sadda, Ruth Hogg, Tunde Peto, Imre LengyelAbstractRecent developments in imaging technologies now allow the documentation, qualitative and quantitative evaluation of peripheral retinal lesions. As wide field retinal imaging, capturing both the central and peripheral retina up to 200° eccentricity, is becoming readily available the question is: what is it that we gain by imaging the periphery? Based on accumulating evidence it is clear...
Source: Progress in Retinal and Eye Research - October 11, 2018 Category: Opthalmology Source Type: research

Presbyopia: Effectiveness of correction strategies
Publication date: Available online 19 September 2018Source: Progress in Retinal and Eye ResearchAuthor(s): James S. Wolffsohn, Leon N. DaviesAbstractPresbyopia is a global problem affecting over a billion people worldwide. The prevalence of unmanaged presbyopia is as high as 50% of those over 50 years of age in developing world populations due to a lack of awareness and accessibility to affordable treatment, and is even as high as 34% in developed countries. Definitions of presbyopia are inconsistent and varied, so we propose a redefinition that states “presbyopia occurs when the physiologically normal age-related reduct...
Source: Progress in Retinal and Eye Research - September 21, 2018 Category: Opthalmology Source Type: research

New concepts in the diagnosis and management of choroidal metastases
Publication date: Available online 19 September 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Thibaud Mathis, Pauline Jardel, Olivier Loria, Benoit Delaunay, Anh-minh Nguyen, Francesco Lanza, Carlo Mosci, Jean-Pierre Caujolle, Laurent Kodjikian, Juliette ThariatAbstractThe most frequent site of ocular metastasis is the choroid. The occurrence of choroidal metastases has increased steadily due to the longer survival of metastatic patients and the improvement of diagnostic tools. Fundoscopy, ultrasonography, and fluorescein angiography are now complemented by indocyanine green angiography and optical coherence t...
Source: Progress in Retinal and Eye Research - September 21, 2018 Category: Opthalmology Source Type: research

Editorial Board
Publication date: September 2018Source: Progress in Retinal and Eye Research, Volume 66Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - September 15, 2018 Category: Opthalmology Source Type: research

Patient-derived induced pluripotent stem cells for modelling genetic retinal dystrophies
Publication date: Available online 11 September 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Leah P. Foltz, Dennis O. CleggAbstractThe human retina is a highly complex tissue that makes up an integral part of our central nervous system. It is astonishing that our retina works seamlessly to provide one of our most critical senses, and it is equally devastating when a disease destroys a portion of the retina and robs people of their vision. After decades of research, scientists are beginning to understand retinal cells in a way that can benefit the millions of individuals suffering from inherited blindness. Thi...
Source: Progress in Retinal and Eye Research - September 12, 2018 Category: Opthalmology Source Type: research

The peripheral eye: A neurogenic area with potential to treat retinal pathologies?
Publication date: Available online 8 September 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Marta Fernández-Nogales, Verónica Murcia-Belmonte, Holly Yu Chen, Eloísa HerreraAbstractNumerous degenerative diseases affecting visual function, including glaucoma and retinitis pigmentosa, are produced by the loss of different types of retinal cells. Cell replacement therapy has emerged as a promising strategy for treating these and other retinal diseases. The retinal margin or ciliary body (CB) of mammals has been proposed as a potential source of cells to be used in degenerative conditions affecting the retina b...
Source: Progress in Retinal and Eye Research - September 8, 2018 Category: Opthalmology Source Type: research

Gene therapy for visual loss: Opportunities and concerns
Publication date: Available online 29 August 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Jia Hui Lee, Jiang-Hui Wang, Jinying Chen, Fan Li, Thomas L. Edwards, Alex W. Hewitt, Guei-Sheung LiuAbstractMany clinical trials using gene therapy have shown significant therapeutic benefits and exceptional safety records. Increasing evidence is verifying the long sought-after promise that gene therapy will genetically ‘cure’ some severely disabling diseases. In particular, the first gene therapy bioproduct for RPE65-associated Leber's congenital amaurosis, which was approved by the US Food and Drug Administration ...
Source: Progress in Retinal and Eye Research - August 29, 2018 Category: Opthalmology Source Type: research

Adaptive optics imaging of the human retina
Publication date: Available online 27 August 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Stephen A. Burns, Ann E. Elsner, Kaitlyn A. Sapoznik, Raymond L. Warner, Thomas J. GastAbstractAdaptive Optics (AO) retinal imaging has provided revolutionary tools to scientists and clinicians for studying retinal structure and function in the living eye. From animal models to clinical patients, AO imaging is changing the way scientists are approaching the study of the retina. By providing cellular and subcellular details without the need for histology, it is now possible to perform large scale studies as well as to und...
Source: Progress in Retinal and Eye Research - August 28, 2018 Category: Opthalmology Source Type: research

Corrigendum to molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspective progress in retinal and eye research (2018) Vol 63,107-131
Publication date: Available online 11 August 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Marina França Dias, Kwangsic Joo, Jessica A. Kemp, Silvia Ligório Fialho, Armando da Silva Cunha, Se Joon Woo, Young Jik Kwon (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - August 11, 2018 Category: Opthalmology Source Type: research

Neurotrophic keratopathy
Publication date: Available online 23 April 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Harminder S. Dua, Dalia G. Said, Elisabeth M. Messmer, Maurizio Rolando, Jose M. Benitez-del-Castillo, Parwez N. Hossain, Alex J. Shortt, Gerd Geerling, Mario Nubile, Francisco C. Figueiredo, Saaeha Rauz, Leonardo Mastropasqua, Paolo Rama, Christophe BaudouinAbstractNeurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. Sensory nerves serve nociceptor and trophi...
Source: Progress in Retinal and Eye Research - August 3, 2018 Category: Opthalmology Source Type: research