Progress in Retinal and Eye Research 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Retinal capillary perfusion: Spatial and temporal heterogeneity
Publication date: Available online 13 February 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Dao-Yi Yu, Stephen J. Cringle, Paula K. Yu, Chandrakumar Balaratnasingam, Andrew Mehnert, Marinko V. Sarunic, Dong An, Er-Ning SuAbstractThe central role of the cardiovascular system is to maintain adequate capillary perfusion. The spatially and temporally heterogeneous nature of capillary perfusion has been reported in some organs. However, such heterogeneous perfusion properties have not been sufficiently explored in the retina. Arguably, spatial and temporal heterogeneity of capillary perfusion could be more predomi...
Source: Progress in Retinal and Eye Research - February 13, 2019 Category: Opthalmology Source Type: research
Editorial Board
Publication date: January 2019Source: Progress in Retinal and Eye Research, Volume 68Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - January 23, 2019 Category: Opthalmology Source Type: research
Insights into photoreceptor ciliogenesis revealed by animal models
This report will update the reader on late developments in photoreceptor ciliogenesis and transition zone formation, specifically in mouse photoreceptors, focusing on early events in photoreceptor ciliogenesis. The connecting cilium, an elongated and narrow structure through which all outer segment proteins and membrane components must traffic, functions as a gate that controls access to the outer segment. Here we will review genes and their protein products essential for basal body maturation and for CC/TZ genesis, sorted by phenotype. Emphasis is given to naturally occurring mouse mutants and gene knockouts that interfer...
Source: Progress in Retinal and Eye Research - December 25, 2018 Category: Opthalmology Source Type: research
On the origin of proteins in human drusen: The meet, greet and stick hypothesis
Publication date: Available online 17 December 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Arthur A. Bergen, Swati Arya, Céline Koster, Matthew G. Pilgrim, Dagmara Wiatrek-Moumoulidis, Peter van der Spek, Stefanie M. Hauck, Camiel J.F. Boon, Eszter Emri, Alan J. Stewart, Imre LengyelAbstractRetinal drusen formation is not only a clinical hallmark for the development of age-related macular degeneration (AMD) but also for other disorders, such as Alzheimer's disease and renal diseases. The initiation and growth of drusen is poorly understood. Attention has focused on lipids and minerals, but relatively little...
Source: Progress in Retinal and Eye Research - December 17, 2018 Category: Opthalmology Source Type: research
Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance
Publication date: Available online 12 December 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Paul G. McMenamin, Daniel Saban, Samantha J. DandoAbstractIn the eye immune defenses must take place in a plethora of differing microenvironments ranging from the corneal and conjunctival epithelia facing the external environment to the pigmented connective tissue of the uveal tract containing smooth muscle, blood vessels and peripheral nerves to the innermost and highly protected neural retina. The extravascular environment of the neural retina, like the brain parenchyma, is stringently controlled to maintain conditio...
Source: Progress in Retinal and Eye Research - December 13, 2018 Category: Opthalmology Source Type: research
Posterior staphyloma in pathologic myopia
Publication date: Available online 8 December 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Kyoko Ohno-Matsui, Jost B. JonasAbstractA posterior staphyloma is an outpouching of a circumscribed region of the posterior fundus and has been considered a hallmark of pathologic myopia. Occurring in highly myopic eyes, it is histologically characterized by a relatively abrupt scleral thinning starting at the staphyloma edge, a pronounced de-arrangement of scleral collagen fibrils and a marked choroidal thinning, which is the most marked at the staphyloma edge and which occurs in addition to the axial elongation-associ...
Source: Progress in Retinal and Eye Research - December 9, 2018 Category: Opthalmology Source Type: research
Wnt Signaling in vascular eye diseases
Publication date: Available online 1 December 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Zhongxiao Wang, Chi-Hsiu Liu, Shuo Huang, Jing ChenAbstractThe Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both during the eye development and in vascular eye diseases. Wnt signaling participates in regulating multiple vascular beds in the eye including regression of the hyaloid vessels, and development of structured layers of vasculature in the retina. Loss-of-function mutations in Wnt signa...
Source: Progress in Retinal and Eye Research - December 2, 2018 Category: Opthalmology Source Type: research
Reconsidering the central role of mucins in dry eye and ocular surface diseases
Publication date: Available online 22 November 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Christophe Baudouin, Maurizio Rolando, Jose M. Benitez Del Castillo, Elisabeth M. Messmer, Francisco C. Figueiredo, Murat Irkec, Gysbert Van Setten, Marc LabetoulleAbstractMucins are key actors in tear film quality and tear film stability. Alteration of membrane-bound mucin expression on corneal and conjunctival epithelial cells and/or gel-forming mucin secretion by goblet cells (GCs) promotes in ocular surface diseases and dry eye disease (DED). Changes in the mucin layer may lead to enhanced tear evaporation eventual...
Source: Progress in Retinal and Eye Research - November 23, 2018 Category: Opthalmology Source Type: research
Return of function after CNS axon regeneration: Lessons from injury-responsive intrinsically photosensitive and alpha retinal ganglion cells
Publication date: Available online 17 November 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Martin Berry, Zubair Ahmed, Ann LoganAbstractThis review addresses issues relating to the survival and axon regeneration of both intrinsically photosensitive retinal ganglion cells (ipRGC) and αRGC, and possible ensuing patterns of functional recovery after optic nerve crush, all of which are broadly relevant to recovery from injury in the central nervous system (CNS) as whole. Although much needs to be clarified about the connectivity, function and patterns of myelination of regenerated CNS axons, the results of rece...
Source: Progress in Retinal and Eye Research - November 18, 2018 Category: Opthalmology Source Type: research
Corneal pain and experimental model development
Publication date: Available online 16 November 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Tina B. McKay, Yashar Seyed-Razavi, Chiara E. Ghezzi, Gabriela Dieckmann, Thomas J.F. Nieland, Dana M. Cairns, Rachel E. Pollard, Pedram Hamrah, David L. KaplanAbstractThe cornea is a valuable tissue for studying peripheral sensory nerve structure and regeneration due to its avascularity, transparency, and dense innervation. Somatosensory innervation of the cornea serves to identify changes in environmental stimuli at the ocular surface, thereby promoting barrier function to protect the eye against injury or infection....
Source: Progress in Retinal and Eye Research - November 17, 2018 Category: Opthalmology Source Type: research
Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives
Publication date: Available online 13 November 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Sylvia J. Gasparini, Sílvia Llonch, Oliver Borsch, Marius AderAbstractThe mammalian retina displays no intrinsic regenerative capacities, therefore retinal degenerative diseases such as age-related macular degeneration (AMD) or retinitis pigmentosa (RP) result in a permanent loss of the light-sensing photoreceptor cells. The degeneration of photoreceptors leads to vision impairment and, in later stages, complete blindness. Several therapeutic strategies have been developed to slow down or prevent further retinal degen...
Source: Progress in Retinal and Eye Research - November 14, 2018 Category: Opthalmology Source Type: research
Biomechanics of the human lens and accommodative system: Functional relevance to physiological states
Publication date: Available online 12 November 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Kehao Wang, Barbara K. PierscionekAbstractThe ability of the human lens to accommodate is mediated by the ciliary muscle and zonule; the manifest optical power changes depend on the shape and material properties of the lens. The latter are difficult to measure with accuracy and, given the dynamic aspects of accommodation and the ageing of cells and tissues, the biomechanics of the lens is neither fixed nor constant. A range of techniques have been developed to measure both ageing trends and spatial variations in the me...
Source: Progress in Retinal and Eye Research - November 12, 2018 Category: Opthalmology Source Type: research
Editorial Board
Publication date: November 2018Source: Progress in Retinal and Eye Research, Volume 67Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - November 11, 2018 Category: Opthalmology Source Type: research
Stemming retinal regeneration with pluripotent stem cells
Publication date: Available online 9 November 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Zi-Bing Jin, Mei-Ling Gao, Wen-Li Deng, Kun-Chao Wu, Sunao Sugita, Michiko Mandai, Masayo TakahashiAbstractCell replacement therapy is a promising treatment for irreversible retinal cell death in diverse diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis pigmentosa (RP) and glaucoma. These diseases are all characterized by the degeneration of one or two retinal cell types that cannot regenerate spontaneously in humans. Aberrant retinal pigment epithelial (RPE) cells can be observed ...
Source: Progress in Retinal and Eye Research - November 11, 2018 Category: Opthalmology Source Type: research
Metabolomics in the study of retinal health and disease
Publication date: Available online 10 November 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Inês Laíns, Mari Gantner, Salome Murinello, Jessica A. Lasky-Su, Joan W. Miller, Martin Friedlander, Deeba HusainAbstractMetabolomics is the qualitative and quantitative assessment of the metabolites (small molecules < 1.5 kDa) in body fluids. The metabolites are the downstream of the genetic transcription and translation processes and also downstream of the interactions with environmental exposures; thus, they are thought to closely relate to the phenotype, especially for multifactorial diseases. In the la...
Source: Progress in Retinal and Eye Research - November 11, 2018 Category: Opthalmology Source Type: research
