Towards the application of precision medicine in age-related Macular Degeneration
Publication date: Available online 29 November 2017 Source:Progress in Retinal and Eye Research Author(s): Raffaella Cascella, Claudia Strafella, Valerio Caputo, Valeria Errichiello, Stefania Zampatti, Filippo Milano, Saverio Potenza, Silvestro Mauriello, Giuseppe Novelli, Federico Ricci, Andrea Cusumano, Emiliano Giardina The review essentially describes genetic and non-genetic variables contributing to the onset and progression of exudative Age-related Macular Degeneration (AMD) in Italian population. In particular, AMD susceptibility within Italian population is contributed to by genetic variants, accounti...
Source: Progress in Retinal and Eye Research - November 29, 2017 Category: Opthalmology Source Type: research

Retinal lipid and glucose metabolism and angiogenesis in the retina
Publication date: Available online 22 November 2017 Source:Progress in Retinal and Eye Research Author(s): Jean-Sebastien Joyal, Mari Gantner, Lois E.H. Smith (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - November 24, 2017 Category: Opthalmology Source Type: research

Retinal vasculature development in health and disease
Publication date: Available online 10 November 2017 Source:Progress in Retinal and Eye Research Author(s): Senthil Selvam, Tejas Kumar, Marcus Fruttiger Development of the retinal vasculature is based on highly coordinated signalling between different cell types of the retina, integrating internal metabolic requirements with external influences such as the supply of oxygen and nutrients. The developing mouse retinal vasculature is a useful model system to study these interactions because it is experimentally accessible for intra ocular injections and genetic manipulations, can be easily imaged and develops in a simila...
Source: Progress in Retinal and Eye Research - November 10, 2017 Category: Opthalmology Source Type: research

Mechanisms of macular edema: Beyond the surface
Publication date: Available online 7 November 2017 Source:Progress in Retinal and Eye Research Author(s): Alejandra Daruich, Alexandre Matet, Alexandre Moulin, Laura Kowalczuk, Michaël Nicolas, Alexandre Sellam, Pierre-Raphaël Rothschild, Samy Omri, Emmanuelle Gélizé, Laurent Jonet, Kimberley Delaunay, Yvonne De Kozak, Marianne Berdugo, Min Zhao, Patricia Crisanti, Francine Behar-Cohen Macular edema consists of intra- or subretinal fluid accumulation in the macular region. It occurs during the course of numerous retinal disorders and can cause severe impairment of central vision. Major causes of macul...
Source: Progress in Retinal and Eye Research - November 7, 2017 Category: Opthalmology Source Type: research

Development of the hyaloid, choroidal and retinal vasculatures in the fetal human eye
Publication date: Available online 2 November 2017 Source:Progress in Retinal and Eye Research Author(s): Gerard A. Lutty, D. Scott McLeod The development of the ocular vasculatures is perfectly synchronized to provide the nutritional and oxygen requirements of the forming human eye. The fetal vasculature of vitreous, which includes the hyaloid vasculature, vasa hyaloidea propria, and tunica vasculosa lentis, initially develops around 4–6 weeks gestation (WG) by hemo-vasculogenesis (development of blood and blood vessels from a common progenitor, the hemangioblast). This transient fetal vasculature expands around 12 ...
Source: Progress in Retinal and Eye Research - November 2, 2017 Category: Opthalmology Source Type: research