Pulmonary embolism in a young male with tuberculosis and factor V Leiden.
We present a case of a 31-year-old male diagnosed with TB after a 2-month delay. He was treated with an anticoagulant for pulmonary embolism (PE) complicated by pulmonary infarction, and with antibiotics for presumed bacterial pneumonia. The patient did not improve despite in-hospital treatment. Finally, TB was diagnosed with positive sputum smear for acid fast bacilli and subsequent culture of Mycobacterium tuberculosis. Antituberculous therapy was uneventful and the patient was discharged home. Thrombophilia screening revealed a heterozygous factor V Leiden mutation. This case report emphasises that although there is a s...
Source: Pneumonologia i Alergologia Polska - May 10, 2014 Category: Respiratory Medicine Authors: Skowroński M, Elikowski W, Halicka A, Barinow-Wojewódzki A Tags: Pneumonol Alergol Pol Source Type: research
[A 24-year-old male patient with pulmonary veno-occlusive disease - case report].
We report the case of a 24-year-old male patient with increasing dyspnea and exercise intolerance treated with calcium channel blockers and glucocorticosteroids, due to suspicion of pulmonary hypertension and interstitial lung disease, until lung biopsy was performed and a diagnosis of PVOD was established on the basis of the histological analysis of the lung biopsy sample. This case highlights that pulmonary veno-occlusive disease is a disorder that is difficult to diagnose and resistant to medical treatment, which is particularly poor prognostic factor. Due to poor response to medical therapy and high mortality in patien...
Source: Pneumonologia i Alergologia Polska - May 10, 2014 Category: Respiratory Medicine Authors: Cwiek E, Przemęcka M, Marczak J, Kuś J, Langfort R, Górski P Tags: Pneumonol Alergol Pol Source Type: research
Lung abscess due to Streptococcus pneumoniae: a case series and brief review of the literature.
Abstract
Anaerobes used to be the most common cause of community-acquired lung abscess, and Streptococcus species used to be the second most common cause. In recent years, this has been changing. Klebsiella pneumoniae is now an increasing cause of community- acquired lung abscess, but Streptococcus species continue to be major pathogens. Necrotizing pneumonia has generally been regarded as a rare complication of pneumococcal infection in adults. Type 3 Streptococcus pneumoniae was the single most common type implicated in necrosis; however, many other serotypes were implicated. This entity predominately in...
Source: Pneumonologia i Alergologia Polska - May 10, 2014 Category: Respiratory Medicine Authors: Nicolini A, Cilloniz C, Senarega R, Ferraioli G, Barlascini C Tags: Pneumonol Alergol Pol Source Type: research
[Immune alterations in lung cancer - the new therapeutic approach].
Abstract
Lung cancer is the main cause of cancer death worldwide. An advanced stage of the disease at the time of diagnosis, observed in the majority of cases, does not allow for introduction of radical treatment or makes the treatment ineffective. Lung cancer as a solid tumour with a very low antigenicity escapes immune surveillance, and cytotoxic cells attack. Cytotoxic lymphocytes play a key role in anticancer defence, but the population of these cells individually differs. Many suppressor and regulatory mechanisms inhibit the recognition of tumour antigens by dendritic and cytotoxic cell activation. Th...
Source: Pneumonologia i Alergologia Polska - May 10, 2014 Category: Respiratory Medicine Authors: Domagała-Kulawik J, Osińska I Tags: Pneumonol Alergol Pol Source Type: research
[Influence of inhaler and fine particle on efficacy of inhalation therapy in COPD].
Abstract
Orally inhaled products delivered via inhalation exert their effect directly to the target organ. This allows to administer a very low dose of a drug compared with an oral route with similar clinical effect and significantly reduced toxicity. However inhalation therapy is also limited by several factors. Delivery of the desired dose of the drug to the airways depends on a type of the inhaler - pressurised metered-dose inhaler (pMDI) or dry powder inhaler (DPI), inhaler characteristics (low or high internal resistance, diameter of particles and distribution of the generated aerosol fine particles),...
Source: Pneumonologia i Alergologia Polska - May 10, 2014 Category: Respiratory Medicine Authors: Sliwiński P, Chazan R, Dąbrowiecki P, Jahnz-Różyk K, Mróz R, Pirożyński M Tags: Pneumonol Alergol Pol Source Type: research
[Current methods to detect EGFR gene mutations as predictive factor for targeted therapies in non-small cell lung cancer - is there a "golden standard" in diagnostics?].
Abstract
According to current Polish and international recommendations, detection of EGFR gene somatic mutations is the essential part of routine diagnostic algorithm in advanced NSCLC patients considered for tyrosine kinase inhibitor therapy. Molecular heterogeneity of tumor tissue and cytology materials used for molecular diagnostics is challenging for classic methods of genetic analysis, such as Sanger sequencing, driving the development and implementation of specialized, highly sensitive techniques for mutations detection. Constant, dynamic progress in molecular biology techniques, particularly develop...
Source: Pneumonologia i Alergologia Polska - May 10, 2014 Category: Respiratory Medicine Authors: Skroński M, Szpechciński A, Chorostowska-Wynimko J Tags: Pneumonol Alergol Pol Source Type: research
[Usefulness of IGRA and tuberculin skin test in diagnosis of latent tuberculosis infection in the groups threatened with occupational risk factors - commentary to article of D. Borkowska et al].
PMID: 24793157 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - May 10, 2014 Category: Respiratory Medicine Authors: Targowski T Tags: Pneumonol Alergol Pol Source Type: research
[Systemic treatment of patients with non small cell lung cancer: from nihilism to hope].
PMID: 24615191 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - March 15, 2014 Category: Respiratory Medicine Authors: Jacek Jassem JJ Tags: Pneumonol Alergol Pol Source Type: research
Impact of chronic obstructive pulmonary disease (COPD) on patient's life and his family.
CONCLUSIONS: The results of the study confirmed the significant impact of the disease and addiction to smoking not only on patients' life but also on their families.
PMID: 24615192 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - March 15, 2014 Category: Respiratory Medicine Authors: Kupryś-Lipińska I, Kuna P Tags: Pneumonol Alergol Pol Source Type: research
Factors influencing adherence to treatment in COPD patients and its relationship with disease exacerbations.
CONCLUSIONS: Lack of systematic treatment is the main risk factor for COPD exacerbations and hospitalisation rate. A subjective sense of relief after drugs is a factor improving patients' compliance.
PMID: 24615193 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - March 15, 2014 Category: Respiratory Medicine Authors: Wiśniewski D, Porzezińska M, Gruchała-Niedoszytko M, Niedoszytko M, Słomiński JM, Jassem E Tags: Pneumonol Alergol Pol Source Type: research
Hypofractionated conformal radiotherapy in combination with chemotherapy in limited disease small cell lung cancer patients.
CONCLUSIONS: Shorter duration of RT using hypofractionation results in encouraging outcomes and acceptable toxicity. Completion of all planned CHT cycles is the most important factor for OS.
PMID: 24615194 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - March 15, 2014 Category: Respiratory Medicine Authors: Socha J, Guzowska A, Tyc-Szczepaniak D, Szczęsna A, Kępka L Tags: Pneumonol Alergol Pol Source Type: research
Analysis of treatment results in primary germ cell tumours with mediastinal location: own experience.
CONCLUSIONS: Primary mediastinal germ cell tumours have worse prognosis than do those with gonadal location. Based on our observations and review of the literature, it can be concluded that the results of treatment of non-seminoma type germ cell tumours with primary mediastinal location remain poor. Patients who develop early recurrence or progression during first-line chemotherapy are particularly at risk of unfavourable outcome. Identification of new standards of treatment in tumours resistant to cisplatin require further studies evaluating the effectiveness of new generation cytostatic drugs.
PMID: 24615195 [Pub...
Source: Pneumonologia i Alergologia Polska - March 15, 2014 Category: Respiratory Medicine Authors: Kowalski DM, Knetki-Wróblewska M, Winiarczyk K, Jaśkiewicz P, Orłowski T, Langfort R, Krzakowski M, Olszewski M Tags: Pneumonol Alergol Pol Source Type: research
Health-promoting activities performed by nurses for patients with COPD.
CONCLUSIONS: Nurses' activities in relation to patients suffering from COPD have a mainly educational nature, but unfortunately they are casual, occasional and unplanned. Planned and formal inclusion of nurses in the process of realisation of health promotion programs for patients with COPD is recommended, i.e. by planning funds for the tasks which can be performed by them. More attention should be payed to professional training of nurses for realisation of the process of health education, especially anti-smoking intervention.
PMID: 24615196 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - March 15, 2014 Category: Respiratory Medicine Authors: Dobrowolska B, Mazurek H, Slusarska B, Zarzycka D, Charzyńska-Gula M, Cuber T Tags: Pneumonol Alergol Pol Source Type: research
[The role of systemic therapies of non-small cell lung cancer and malignant pleural mesothelioma: updated expert recommendations].
This article presents the current evidence- based recommendations for the use of these methods in clinical practice in NSCLC and malignant pleural mesothelioma.
PMID: 24615197 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - March 15, 2014 Category: Respiratory Medicine Authors: Jassem J, Biernat W, Bryl M, Chorostowska-Wynimko J, Dziadziuszko R, Krawczyk P, Kordek R, Kowalski DM, Krzakowski M, Olszewski W, Orłowski T, Ramlau R, Witold Rzyman WR Tags: Pneumonol Alergol Pol Source Type: research
[Diagnostic difficulties in diagnosis of Hodgkin's disease in a young man - a case report].
Conclusions: Mediastinal tumours may cause diagnostic difficulties and, to avoid mistakes, typical histological studies should be complemented by targeted immunohistochemical tests.
PMID: 24615198 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - March 15, 2014 Category: Respiratory Medicine Authors: Adam Bubel AB, Rogoziński P, Wandzel P, Krzysztof Bruliński KB Tags: Pneumonol Alergol Pol Source Type: research
