[Granulomatosis with polyangiitis - clinical picture and review of current treatment options].
Abstract
Granulomatosis with polyangiitis (GPA) is a rare disease of unknown aetiology, characterized by necrotizing inflammation of small and medium-sized vessels and formation of granulomas. The disease typically involves the upper and lower respiratory tracts and the kidneys, but it can occur in many other locations, often giving a surprising clinical picture. The majority of patients have autoantibodies against cytoplasm of neutrophils (ANCA), of which a pathogenetic role is postulated. The disease affects mostly middle-aged and elderly people, with a predominance of Caucasians. Before the era of immun...
Source: Pneumonologia i Alergologia Polska - January 17, 2014 Category: Respiratory Medicine Authors: Lembicz M, Batura-Gabryel H, Nowicka A Tags: Pneumonol Alergol Pol Source Type: research
[Lung function assessment in the elderly].
PMID: 24142777 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Franczuk M Tags: Pneumonol Alergol Pol Source Type: research
[Tuberculosis and HIV in the world, in Europe and in Poland].
PMID: 24142778 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Rowińska-Zakrzewska E Tags: Pneumonol Alergol Pol Source Type: research
Incidence of tuberculosis and mycobacteriosis among HIV-infected patients - clinical and epidemiological analysis of patients from north-eastern Poland.
CONCLUSION: In our material of 389 HIV-infected patients, tuberculosis was diagnosed in 41 (10.5%) and mycobacterial diseases in 4 (1.03%). In 42% of co-infected patients (HIV+TB or mycobacteriosis) the diagnosis of both diseases was made at the same time. In these patients, a deep deficit of cellular immunity (CD4 < 50 cells/μL) was observed more frequently than in patients diagnosed with TB or mycobacteriosis in the later course of HIV. HIV RNA viral load was significantly higher in the group diagnosed simultaneously than in the remaining patients with HIV and TB or mycobacteriosis coinfection.
PMID: 24142779...
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Lucejko M, Grzeszczuk A, Rogalska M, Flisiak R Tags: Pneumonol Alergol Pol Source Type: research
Quality of spirometry in the elderly.
CONCLUSIONS: The most common error was the lack of a plateau at the end of exhalation. Therefore, paying particular attention to the final phase of exhalation during spirometry should, as a result, increase the percentage of correctly performed spirometric tests in the elderly.
PMID: 24142780 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Czajkowska-Malinowska M, Tomalak W, Radliński J Tags: Pneumonol Alergol Pol Source Type: research
The application of MDCT in the diagnosis of chest trauma.
CONCLUSIONS: MDCT was a valuable diagnostic method in recognition of chest trauma, characterized by high sensitivity and specificity in the assessment of life-threatening injures and for depicting tracheal and bronchial injuries. The diagnostic value of CXR was low. The compatibility of MCTD and intraoperative assessment was confirmed, with the exception of diaphragm injures and lung laceration. Change of treatment modality was certified after MDCT in 83% of patients.
PMID: 24142781 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Błasińska-Przerwa K, Pacho R, Bestry I Tags: Pneumonol Alergol Pol Source Type: research
Efficacy and safety of a 12-week therapy with a new formulation of fluticasone propionate at doses of 125 and 250 μg administered through a new generation cyclohaler twice daily, in comparison to fluticasone propionate 500 μg dry powder inhaler twice dail.
CONCLUSIONS: Fluticasone administered through the new generation cyclohaler, compared to original fluticasone DPI, allows a twofold reduction in drug dose, retaining in new formulation clinical efficacy that corresponds to the reference drug at twice the dose. New formulation of fluticasone administered through the new generation cyclohaler has a safety profile clinically comparable to the reference drug.
PMID: 24142782 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Kupryś-Lipińska I, Tworek D, Vanderbist F, Bocheńska-Marciniak M, Kuna P Tags: Pneumonol Alergol Pol Source Type: research
Transthyretin amyloidosis with pulmonary involvement in a patient with monoclonal gammapathy.
We report on concomitant monoclonal gammapathy of undermined significance (MGUS) and amyloidosis with non-mutated transthyretin with diffuse lesions in lung parenchyma. A female patient, 67 years old, was admitted with dyspnoea, malaise, weight loss, and disseminated radiological lesions in the lungs. On lung HRCT, signs of pulmonary hypertension, alveolar and interstitial involvement, with thickening of septal lines were found. Echocardiography revealed severe pulmonary hypertension, and electromyography revealed sensoromotoric polyneuropathy with axon and myelin damage. Pathological assessment of lung specimens revealed ...
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Kruczak K, Duplaga M, Sanak M, Papla B, Soja J, Niżankowska-Mogilnicka E, Sładek K Tags: Pneumonol Alergol Pol Source Type: research
Fatal clinical outcome in a patient with sarcoidosis-lymphoma syndrome.
Abstract
A 62-year-old female suspected of malignant disease underwent a splenectomy that revealed noncaseating granulomas in the histological specimen. Chest X-ray (CXR) and lung CT scans suggested sarcoidosis stage II. TBLB showed noncaseating granulomas. A diagnosis of sarcoidosis was made. Initially no treatment was needed as partial remission on CXR and normal lung function were observed. During the follow up she underwent open lung biopsy and axillary lymph node biopsy because of radiological progression with presence of CXR opacities imitating metastases and recurrent lymphadenopathy. No malignant c...
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Goljan-Geremek A, Puścińska E, Bednarek M, Nowiński A, Kamiński D, Ptak J, Bestry I, Langfort R, Staszewska M, Gorecka D Tags: Pneumonol Alergol Pol Source Type: research
[A surprising diagnosis in a male with a tumour of the chest wall - not always lung cancer].
We present a history of a man referred to our department suspected of lung tumour infiltrating the chest wall. Additionally, bone metastatic disease was diagnosed (ribs, vertebral bodies and skull). Thanks to a wide diagnostic approach, ductal cancer of the breast was finally diagnosed, a neoplasm that is extremely rare in male patients, usually presenting as a definite nodule in the nipple area of the breast. This case shows the importance of careful histological evaluation of the chest wall tumour.
PMID: 24142785 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Lewandowska K, Błasińska-Przerwa K, Szołkowska M, Langfort R, Bartosiewicz M, Maszkowska-Kopij K, Kupis W, Kuś J Tags: Pneumonol Alergol Pol Source Type: research
[Interstitial lung disease in patients with polymyositis and dermatomyositis - report of three cases].
We present three cases of PM/DM-related ILD in middle-aged men, with a different clinical and radiological presentation. In all cases, apart from imaging (plain X-ray and HRCT of the chest) and pulmonary function tests, histological evaluation of lung changes was performed. In two cases non-specific interstitial pneumonitis (NSIP) was diagnosed, and in the third - organizing pneumonia along with sarcoid changes in the lymph nodes. Because of decreased pulmonary function all patients were treated with systemic corticosteroids and two of them additionally with azathioprine or cyclophosphamide, and the outcome was good in all...
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Bartosiewicz M, Siemion-Szcześniak I, Sobiecka M, Wyrostkiewicz D, Radwan-Röhrenschef P, Lewandowska K, Langfort R, Oniszh K, Franczuk M, Kuś J Tags: Pneumonol Alergol Pol Source Type: research
[Ischaemic heart disease and hypertension in patients with chronic obstructive pulmonary disease and obstructive sleep apnoea].
Abstract
Chronic obstructive pulmonary disease (COPD) affects almost 10% of the adult population of our country; obstructive sleep apnoea is increasingly being recognized and concerns, according to accepted criteria, 2-9% of females and 4-24% of men. The greatest mortality in chronic obstructive pulmonary disease is not caused by respiratory failure, but cardiovascular complications, including ischaemic heart disease. Obstructive sleep apnoea in half the cases is complicated by hypertension, often refractory to antihypertensive therapy. The paper discusses the pathogenesis of ischaemic heart disease in pat...
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Głuszek J Tags: Pneumonol Alergol Pol Source Type: research
[Thromboprophylaxis in patients with lung disease].
PMID: 24142788 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Dybowska M, Kuca P, Tomkowski W Tags: Pneumonol Alergol Pol Source Type: research
[Advancess in bronchoscopic techniques].
PMID: 24142789 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Chciałowski A Tags: Pneumonol Alergol Pol Source Type: research
[Relationship between obstructive sleep apnea and metabolic sydrome].
PMID: 23996879 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - September 4, 2013 Category: Respiratory Medicine Authors: Januszewicz A, Prejbisz A, Florczak E Tags: Pneumonol Alergol Pol Source Type: research
