[Chronic obstructive pulmonary disease and cardiovascular diseases - 'cardiopulmonary continuum'].
Abstract
Chronic obstructive pulmonary disease (COPD) is characterised by persistent airflow limitation and extrapulmonary comorbidities, which contribute to the overall severity. Some risk factors, with tobacco smoking as the most serious one, lead to a chronic, systemic inflammation that plays the main role in the pathogenesis of COPD and comorbidities, including cardiovascular diseases (CVD). The course of COPD is diverse; it depends on pathologies in the respiratory system and on other organ dysfunctions. CVDs are the most commonly recognised comorbidities in COPD patients. The severity and natural cou...
Source: Pneumonologia i Alergologia Polska - October 27, 2014 Category: Respiratory Medicine Authors: Batura-Gabryel H, Grabicki M Tags: Pneumonol Alergol Pol Source Type: research
POLASTMA - the Polish National Programme of Early Diagnosis and Therapy of Asthma.
Abstract
Asthma represents a growing health, social, and economic issue as it affects a considerable part of the population, adversely affecting patients' quality of life, while its chronic character and severity of symptoms impair family life. It has been estimated that 12% of the population of Poland (4.5 million) suffer from asthma and 16% report wheezes (5.7 million). In order to improve asthma care and patient outcomes, evidence-based recommendations must not only be developed, but also disseminated and implemented at a national and local level, which is key for integration into clinical practice. For...
Source: Pneumonologia i Alergologia Polska - October 27, 2014 Category: Respiratory Medicine Authors: Kuna P, Kupczyk M, Kupryś-Lipińska I Tags: Pneumonol Alergol Pol Source Type: research
[Changes in the newest recommendations on Asthma Management and Prevention - GINA Report 2014. What should we pay attention to?].
PMID: 25133806 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Kupryś-Lipińska I, Kuna P Tags: Pneumonol Alergol Pol Source Type: research
Epidemiological situation of tuberculosis in Poland: Part II. What are the causes of the different epidemiological situation in various regions of Poland?
CONCLUSIONS: In conclusion, the greater number of patients lost from observation, together with the higher density of population in the regions from Group I in comparison with those from Group II, seems to be partly responsible for the difference in the epidemiological situation in the two regions. It is also possible that some patients from Group I are more susceptible to infection and disease caused by Mycobacterium tuberculosis due to their ancestors, who lived in the east of Europe.
PMID: 25133807 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Rowińska-Zakrzewska E, Korzeniewska-Koseła M, Roszkowski-Śliż K Tags: Pneumonol Alergol Pol Source Type: research
Bronchoscopy in immediate diagnosis of smear negative tuberculosis.
CONCLUSIONS: The results of the present study suggests an important place of bronchoscopy in immediate diagnosis of suspected smear negative tuberculosis, thus avoiding inadvertent delays in diagnosing and instituting appropriate treatment.
PMID: 25133808 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Kumar R, Singh M, Gupta N, Goel N Tags: Pneumonol Alergol Pol Source Type: research
Stratification of patients with COPD according to the 2011 GOLD report.
CONCLUSIONS: The COPD population is heterogeneous in reference to the symptoms, value of FEV1, and susceptibility to exacerbations. Clinical symptoms assessed using validated questionnaires characterized COPD patients better than the value of spirometric parameters (which are necessary for diagnosis of this disease). Some patients were difficult to classify, especially those belonging to category C.
PMID: 25133809 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Grzelewska-Rzymowska I, Patora-Mikołajczyk J, Górski P Tags: Pneumonol Alergol Pol Source Type: research
Prognostic value of serum C-reactive protein (CRP) and cytokeratin 19 fragments (Cyfra 21-1) but not carcinoembryonic antigen (CEA) in surgically treated patients with non-small cell lung cancer.
CONCLUSIONS: In the present study, concerning surgically treated NSCLC patients, preoperative CRP > 10 mg/L and Cyfra 21-1 > 2 ng/mL were the only negative prognostic indicators, while pT and p-stage were significant postoperative prognostic indicators.
PMID: 25133810 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Szturmowicz M, Rudziński P, Kacprzak A, Langfort R, Bestry I, Broniarek-Samson B, Orłowski T Tags: Pneumonol Alergol Pol Source Type: research
Detecting Mycobacterium tuberculosis complex DNA, based on post-mortem examination of hilar lymph nodes with real-time PCR: initial study.
CONCLUSIONS: Real-time PCR Xpert MTB/RIF was capable of detecting M. tuberculosis complex DNA in a patient with tuberculosis recognised on autopsy. In the remaining patients, no M. tuberculosis complex DNA was found, in accordance with negative results of histological examination. Since the technology of cartridges has changed, it is no longer possible to use real-time PCR Xpert MTB/RIF (Cepheid USA) on post-mortem material.
PMID: 25133811 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Rzechorzek W, Szańkowska M, Szczepankiewicz B, Cyran-Chlebicka A, Safianowska A Tags: Pneumonol Alergol Pol Source Type: research
[Methodological recommendations for the diagnostics of EGFR gene mutations and ALK gene rearrangement in the selection of non-small-cell lung cancer patients to molecularly targeted therapies].
We present Polish methodological recommendations for molecular analysis of EGFR and ALK genetic abnormalities. Recommendations specify clinical indications for testing, sample types and handling, as well as requirements for laboratories performing molecular diagnostics.
PMID: 25133812 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Krawczyk P, Chorostowska-Wynimko J, Dziadziuszko R, Jassem J, Krzakowski M, Langfort R, Puacz E, Wasąg B, Wojas-Krawczyk K Tags: Pneumonol Alergol Pol Source Type: research
Immediate hypersensitivity reaction with mango.
We report a 50-year-old man with immediate type I hypersensitivity to mango, who developed cough, wheezing dyspnoea, generalised itching and abdominal discomfort after ingestion of mango. Life threatening event can also happen making it imperative to diagnose on time, so as to prevent significant morbidity and potential mortality.
PMID: 25133813 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Shah A, Gera K Tags: Pneumonol Alergol Pol Source Type: research
Granulomatosis with polyangiitis (Wegener's granulomatosis) with hard palate and bronchial perforations treated with rituximab - a case report.
We present a case of a 57-year-old woman suffering from granulomatosis with polyangiitis (GPA), who in the seventh months of immunosuppressive treatment (cyclophosphamide) progressed with new pulmonary changes and perforations of the hard palate and bronchi. Rituximab was introduced resulting in B-cell depletion and disappearance of anti-PR3 antibody. Palatal holes have substantially diminished and all bronchial perforations disappeared, covered by fibrous tissue. In the fourth month after rituximab administration, large scarring obstruction of the right main bronchus with upper and middle lobes atelectasis emerged. Becaus...
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Kosałka J, Bazan-Socha S, Zugaj A, Ignacak M, Zuk J, Sokołowska B, Musiał J Tags: Pneumonol Alergol Pol Source Type: research
[Pneumocystis pneumonia in HIV-infected patients with cytomegalovirus co-infection. Two case reports and a literature review].
Abstract
Pneumocystis pneumonia (PCP) is one of the infectious lung diseases diagnosed in HIV-infected patients. The pathogen responsible for the development of this opportunistic infection is an atypical fungus called Pneumocystis jiroveci. PCP remains the most common disorder diagnosed at the onset of acquired immunodeficiency syndrome (AIDS), especially in individuals not aware of their HIV infection. The most important risk factor of PCP development in HIV-infected person is the decrease of T CD4+ cell number below 200/mcL. Clinical symptoms consist of: chronic cough, dyspnoea and weakness. Arterial bl...
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Polaczek MM, Zych J, Oniszh K, Szopiński J, Grudny J, Roszkowski-Śliż K Tags: Pneumonol Alergol Pol Source Type: research
[Exercise-induced urticaria and angioedema - case report].
Abstract
Urticaria is a heterogeneous group of disorders, with various clinical manifestations and intensity of symptoms. Urticaria can be induced with a wide variety of environmental stimuli, such as cold, pressure, vibration, sunlight, exercise, temperature changes, heat, and water. In a select group of patients, exercise can induce a spectrum of urticaria symptoms, ranging from cutaneous pruritus and warmth, generalised urticaria, angioedema, and the appearance of such additional manifestations as collapse, upper respiratory distress, and anaphylaxis. Specific provocation tests should be carried out on ...
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Stelmach I, Sztafińska A, Lechańka J, Balcerak J, Jerzyńska J Tags: Pneumonol Alergol Pol Source Type: research
[Ventilator-associated pneumonia and other infections].
Abstract
One of the fundamental elements of therapy in patients hospitalised in the Intensive Care Unit (ICU) is mechanical ventilation (MV). MV enables sufficient gas exchange in patients with severe respiratory insufficiency, thus preserving the proper functioning of organs and systems. However, clinical and experimental studies show that mechanical ventilation may cause severe complications, e.g. lung injury (VALI, VILI), systemic inflammatory response syndrome (SIRS), and, on rare occasions, multiple organ failure (MOF). Mechanical ventilation and especially endotracheal intubation are associated also ...
Source: Pneumonologia i Alergologia Polska - August 20, 2014 Category: Respiratory Medicine Authors: Bobik P, Siemiątkowski A Tags: Pneumonol Alergol Pol Source Type: research
[Microbiological diagnostics in the patients with cystic fibrosis].
PMID: 24964234 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - June 28, 2014 Category: Respiratory Medicine Authors: Augustynowicz-Kopeć E Tags: Pneumonol Alergol Pol Source Type: research
