H. pylori Infection Increases Gastric Mucosal COX2 and mTOR Expression in Chronic Gastritis: Implications for Cancer Progression?
Conclusion These findings suggest that there is a positive feedback loop between H. pylori infection and the pathogenesis of gastric mucosal changes. Also, mTOR and COX2 over expression cause premalignant changes and subsequent tumor occurrence. This may help in providing innovative approaches for the detection of patients-with a higher chance of cancer development, and in trying to introduce effective therapy preventing tumor occurrence, or even using these molecular markers as potential targets for tumors treatment strategies. (Source: Pathophysiology)
Source: Pathophysiology - June 20, 2017 Category: Pathology Source Type: research
Interleukin-6 participation in pathology of ocular diseases
Publication date: Available online 10 June 2017 Source:Pathophysiology Author(s): Forouhe Zahir-Jouzdani, Fatemeh Atyabi, Nazanin Mojtabavi Interleukin-6 (IL-6) is a multifunctional cytokine that affects a variety of cells in the body such as osteoclasts, hepatocytes, endothelial cells, epithelial cells, white and red blood cells and etc. Elevated levels of IL-6 have been detected in many ocular diseases. Studies show that IL-6 has a major role in the pathology of glaucoma, CRVO, macular edema, ocular neovascularization, posterior capsule opacity formation, keratitis, dry eye disease, allergic eye disease, ocular auto...
Source: Pathophysiology - June 11, 2017 Category: Pathology Source Type: research
Breast Cancer Biomarkers at Niger Delta University Hospital: Comparisons with National and International Trends and Clinical Significance
This study indicates that the majority of breast cancer in NDUTH lies at the two ends of the molecular spectrum, that is, luminal A (54.1%), sensitive to hormonal therapy and with a good prognosis, and “triple negative” (4.2%) not hormonally sensitive and with a poor prognosis. (Source: Pathophysiology)
Source: Pathophysiology - June 4, 2017 Category: Pathology Source Type: research
Peri-apneic hemodynamic reactions in obstructive sleep apnea
Publication date: Available online 31 May 2017 Source:Pathophysiology Author(s): Anu Muraja-Murro, Outi Nieminen, Petro Julkunen, Juha Töyräs, Tomi Laitinen, Esa Mervaala Obstructive sleep apnea (OSA) increases cardiovascular morbidity and mortality. Little is known on acute peri-apneic hemodynamic alterations due to apneas. We assessed these rapid changes and how duration of apnea might contribute to them. Eight patients with severe OSA were studied with polysomnography including continuous blood pressure monitoring. Peri-apneic hemodynamic alterations, heart rate, blood pressure, stroke volume, cardiac output a...
Source: Pathophysiology - June 1, 2017 Category: Pathology Source Type: research
Variations in the Cerebrospinal Fluid Proteome Following Traumatic Brain Injury and Subarachnoid Hemorrhage
Conclusions Consistent CSF elevation of CA-I and Prx-2 with concurrent depletion of Hp and Tf may represent a useful combination of biomarkers for the prediction of severity and prognosis following brain injury. (Source: Pathophysiology)
Source: Pathophysiology - May 13, 2017 Category: Pathology Source Type: research
Association between matrix metaloproteinases 2-1306C/T polymorphism and the risk of coronary artery disease in Iranian population
Conclusions Result of this study provides some evidences that the MMP2-1306 polymorphism can be associated with coronary artery disease. Further longitudinal studies including more sample sizes are required to confirm this protective effect. (Source: Pathophysiology)
Source: Pathophysiology - May 8, 2017 Category: Pathology Source Type: research
Vascular lesions of the female genital tract: Clinicopathologic findings and application of the ISSVA classification
Conclusion Vascular lesions of the female genital tract consist of lesions with different morphology by organ and of probably different pathogenesis. The ISSVA classification can be adopted for most of these lesions. WT1 should be best considered as a marker of endothelia with proliferative capacity rather than a marker of neoplastic endothelia. (Source: Pathophysiology)
Source: Pathophysiology - April 29, 2017 Category: Pathology Source Type: research
Vascular lesions of the female genital tract Clinicopathologic findings and application of the ISSVA classification
Conclusion Vascular lesions of the female genital tract consist of lesions with different morphology by organ and of probably different pathogenesis. The ISSVA classification can be adopted for most of these lesions. WT1 should be best considered as a marker of endothelia with proliferative capacity rather than a marker of neoplastic endothelia. (Source: Pathophysiology)
Source: Pathophysiology - April 23, 2017 Category: Pathology Source Type: research
Pro and Anti-Inflammatory Cytokine Levels (TNF- α, IL-1β, IL-6 and IL-10) in Rat Model of Neuroma
In conclusion IL-6, and IL-1 β may have a role in the formation of traumatic neuroma while IL-10 may inhibit neuroma formation. (Source: Pathophysiology)
Source: Pathophysiology - April 11, 2017 Category: Pathology Source Type: research
An investigation on the effects of the angles between the mitral and aortic orifice during diastolic period using FSI
Conclusion These findings provides significant insights on hemodynamic conditions and structural displacement, which from a clinical point of view would be useful in determining different conditions of cardiac diseases. (Source: Pathophysiology)
Source: Pathophysiology - March 18, 2017 Category: Pathology Source Type: research
Regulation of Mitochondrial Structure and Function by Protein Import: A Current Review
Publication date: Available online 16 March 2017 Source:Pathophysiology Author(s): Kanchanjunga Prasai By generating the majority of a cell’s ATP, mitochondria permit a vast range of reactions necessary for life. Mitochondria also perform other vital functions including biogenesis and assembly of iron-sulfur proteins, maintenance of calcium homeostasis, and activation of apoptosis. Accordingly, mitochondrial dysfunction has been linked with the pathology of many clinical conditions including cancer, type 2 diabetes, cardiomyopathy, and atherosclerosis. The ongoing maintenance of mitochondrial structure and function re...
Source: Pathophysiology - March 16, 2017 Category: Pathology Source Type: research
Immunohistochemical analysis of PTEN, HER2/neu, and ki67 expression in patients with gastric cancer and their association with survival
Conclusion All the studied molecular markers, was significantly correlated with pathological T stage that significantly affected both OS and DFS rates. These findings indicate that these markers have an important role in gastric cancer growth and dissemination so these markers can be used as a prognostic biomarker. In addition, therapies targeting Her2 and PTEN may help develop novel therapeutics for gastric cancer. (Source: Pathophysiology)
Source: Pathophysiology - February 24, 2017 Category: Pathology Source Type: research
Silymarin attenuates aspartame-induced variation in mouse behaviour, cerebrocortical morphology and oxidative stress markers
Conclusion The study shows that co-administration of silymarin with aspartame was associated with significant attenuation of central effects, when compared to administration of aspartame alone. (Source: Pathophysiology)
Source: Pathophysiology - February 15, 2017 Category: Pathology Source Type: research
Lung injury induced by Bisphenol A: A food contaminant, is ameliorated by selenium supplementation
This study aimed to investigate the impact of chronic exposure to BPA on the lung tissue of adult male rats as well as any possible alleviating effects resulting from selenium (Se) treatment. Chronic exposure to BPA resulted in prominent inflammation and oxidative stress responses as evidenced by an increase in levels of malondialdehyde (MDA), reduced concentrations of superoxide dismutase (SOD), and upregulation of Interleukin-18 (IL-18) expression in lung tissue. In addition, chronic exposure led to modulation of the fibrosis-related gene expression, as we observed augmented follistatin-like1 (FSTL1) expression and dimin...
Source: Pathophysiology - February 12, 2017 Category: Pathology Source Type: research
Chronic administration of gabapentin and a gabapentin-carbamazepine combination reversibly suppress testicular function in male Wistar rats (Rattus norvegicus)
Publication date: Available online 13 February 2017 Source:Pathophysiology Author(s): Osuntokun Opeyemi Samson, Olayiwola Gbola, Oladele Ayowole, Ola Idowu, AyokaAbiodun Oludele The effect of chronic administration of gabapentin, carbamazepine or a gabapentin-carbamazepine combination on testicular function in male rats was investigated to determine the effect of combining reduced doses of anti-epileptic drugs on the management of seizures, particularly with respect to the testis sequellae of chronic anti-epileptic administration. Male rats were randomized into four groups (n=10). Each group received daily intraperi...
Source: Pathophysiology - February 12, 2017 Category: Pathology Source Type: research
