Folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF- κB, IL-1β production and lipid peroxidation mediataed cell injury
In conclusion, folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-κB, IL-1β production and lipid peroxidation mediataed cell injury. (Source: Pathophysiology)
Source: Pathophysiology - February 10, 2017 Category: Pathology Source Type: research
Ceftriaxone attenuates glutamate-mediated neuro-inflammation and restores BDNF in MPTP model of Parkinson's disease in rats
Publication date: Available online 10 February 2017 Source:Pathophysiology Author(s): Baninder Kaur, Atish Prakash The present study is designed to investigate the role of glutamate transporter in neuroprotection of ceftriaxone against MPTP induced PD animal model. Young male Wistar rats were subjected to intra-nigral administration of MPTP for the induction of Parkinson’s disease. Glutamate modulators like ceftriaxone (CFX), Memantine (MEM) and Dihydrokainate (DHK) were administered to MPTP-lesioned rats. Different behavioral alterations were assessed in between the study period. Animals were sacrificed immediately ...
Source: Pathophysiology - February 10, 2017 Category: Pathology Source Type: research
High salt intake does not aggravate glucose dysregulation and dyslipidemia induced by estrogen-progestin oral contraceptive
Conclusion The results from the present study indicate that glucose dysfunction and dyslipidemia induced by OC use, but not those induced by increased dietary salt are associated with elevated plasma C-reactive protein. Besides, increased dietary salt does not worsen abnormal cardiometabolic impact of OC use. (Source: Pathophysiology)
Source: Pathophysiology - February 10, 2017 Category: Pathology Source Type: research
IL-10 and TGF- β: Roles in Chondroprotective Effects of Glucosamine in Experimental Osteoarthritis?
Conclusion Our results showed that IL-10 and TGF-β1 possibly mediate GlcN chondroprotective effects in OA. Both serum biomarkers can be useful in the follow-up of articular cartilage damage in clinical settings. (Source: Pathophysiology)
Source: Pathophysiology - February 10, 2017 Category: Pathology Source Type: research
Vitamin D Reduces High-Fat Diet Induced Weight Gain and C-Reactive Protein, Increases Interleukin-10, and Reduces CD86 and Caspase-3
Publication date: Available online 27 January 2017 Source:Pathophysiology Author(s): Asmaa Gomaa, Ebtihal A. Abd El-Aziz Obesity can be associated with dysfunction of the immune system. An increased risk of obesity has been reported among individuals with low levels of vitamin D. However, much is still unknown about the link between vitamin D and dysfunction of the spleen and immune system in obesity. Therefore, the objectives of this study were to evaluate the effects of a high-fat diet (HFD) on the spleen and immune system and to determine the protective effects of chronic treatment with vitamin D in reversing the de...
Source: Pathophysiology - January 27, 2017 Category: Pathology Source Type: research
