Royal jelly supplementation reduces skeletal muscle lipotoxicity and insulin resistance in aged obese rats
ConclusionAging and HFD were associated with disturbed metabolism, and muscle lipotoxicity and inflammation, while RJ could counteract muscle lipotoxicity in rats and reduce IR, most likely due to an anti–inflammatory effect. (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Melatonin attenuates chronic immobilization stress-induced muscle atrophy in rats: Influence on lactate-to-pyruvate ratios and Na+/K+ ATPase activity
This study assessed the protective effect of melatonin against muscle atrophy provoked by chronic immobilization stress (CIS). CIS was induced in rats by limiting their trunk movement for 90 min daily for 6 weeks. Rats subjected to the CIS procedure demonstrated a substantial decrease in body weight, an increase in serum corticosterone, muscle atrophy, and an increase in atrogin-1 mRNA levels. An increase in the serum lactate-to-pyruvate ratio and the oxidative stress accompanied by a reduction of Na+/K+ ATPase activity could be responsible for these changes. Melatonin efficiently attenuated CIS-induced deleterious effec...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Heart remodeling produced by aortic stenosis promotes cardiomyocyte apoptosis mediated by collagen V imbalance
Publication date: Available online 8 July 2018Source: PathophysiologyAuthor(s): Paula Grippa Sant’Ana, Sabrina Setembre Batah, Patrícia Santos Leão, Walcy Rosolia Teodoro, Sérgio Luiz Borges de Souza, Gustavo Augusto Ferreira Mota, Danielle Fernandes Vileigas, Vitor Loureiro da Silva, Dijon Henrique Salomé de Campos, Katashi Okoshi, Vera Luiza Capelozzi, Antonio Carlos Cicogna, Alexandre Todorovic FabroAbstractCardiac remodeling (CR) is a structural change of the heart due to chronic hemodynamic overload related to changes in both myocyte and extracellular matrix (ECM). We investigated that the imbalance of collagen ...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Resveratrol prevents high-fat diet-induced obesity and oxidative stress in rabbits
Publication date: Available online 9 July 2018Source: PathophysiologyAuthor(s): A. Jimoh, Y. Tanko, A. Ahmed, A. Mohammed, J.O. Ayo (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Catechin, quercetin and taxifolin improve redox and biochemical imbalances in rotenone-induced hepatocellular dysfunction: Relevance for therapy in pesticide-induced liver toxicity?
This study investigated the protective effect of three flavonoids, catechin, quercetin and taxifolin (2,3-Dihydroquercetin) in rotenone-induced hepatotoxicity. Male Wistar rats were administered rotenone for 10 days followed by post treatment with catechin (5, 10 and 20 mg/kg), quercetin (5, 10 and 20 mg/kg) or taxifolin (0.25, 0.5 and 1 mg/kg), respectively, for 3 days. Bioindices of oxidative stress and hepatocellular injury were measured in serum and tissue homogenate of animals. Rotenone intoxication produced liver damage in rats as reflected in alterations to activities/levels of enzymic and non-enzymic oxidativ...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Resveratrol prevents high-fat diet-induced obesity and oxidative stress in rabbits
Publication date: Available online 9 July 2018Source: PathophysiologyAuthor(s): A. Jimoh, Y. Tanko, A. Ahmed, A. Mohammed, J.O. Ayo (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Catechin, quercetin and taxifolin improve redox and biochemical imbalances in rotenone-induced hepatocellular dysfunction: Relevance for therapy in pesticide-induced liver toxicity?
This study investigated the protective effect of three flavonoids, catechin, quercetin and taxifolin (2,3-Dihydroquercetin) in rotenone-induced hepatotoxicity. Male Wistar rats were administered rotenone for 10 days followed by post treatment with catechin (5, 10 and 20 mg/kg), quercetin (5, 10 and 20 mg/kg) or taxifolin (0.25, 0.5 and 1 mg/kg), respectively, for 3 days. Bioindices of oxidative stress and hepatocellular injury were measured in serum and tissue homogenate of animals. Rotenone intoxication produced liver damage in rats as reflected in alterations to activities/levels of enzymic and non-enzymic oxidativ...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Heart remodeling produced by aortic stenosis promotes cardiomyocyte apoptosis mediated by collagen V imbalance
Publication date: Available online 8 July 2018Source: PathophysiologyAuthor(s): Paula Grippa Sant’Ana, Sabrina Setembre Batah, Patrícia Santos Leão, Walcy Rosolia Teodoro, Sérgio Luiz Borges de Souza, Gustavo Augusto Ferreira Mota, Danielle Fernandes Vileigas, Vitor Loureiro da Silva, Dijon Henrique Salomé de Campos, Katashi Okoshi, Vera Luiza Capelozzi, Antonio Carlos Cicogna, Alexandre Todorovic FabroAbstractCardiac remodeling (CR) is a structural change of the heart due to chronic hemodynamic overload related to changes in both myocyte and extracellular matrix (ECM). We investigated that the imbalance of collagen ...
Source: Pathophysiology - July 8, 2018 Category: Pathology Source Type: research
Oral phenytoin protects against experimental cyclophosphamide-chemotherapy induced hair loss
This study showed that oral phenytoin can suppress hair loss due to CYP therapy in rats; however, further studies are needed to evaluate its potential application in chemotherapy-induced alopecia. (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Folate receptor α is associated with poor clinicopathological perspectives in breast carcinoma
ConclusionOur work demonstrates that FRα is over expressed in IDC compared to non-neoplastic breast tissue. Folate receptor α expression was associated with poor clinicopathological perspective. This work suggests that FRα may be an independent prognostic factor and supports the possibility of using FRα-targeted therapies of breast carcinoma. However, our work requires validation on larger cohort with correlation with survival data of patients. (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Protective effects of Artemisia campestris extract against gastric acid reflux-induced esophageal mucosa injuries
In conclusion, we suggested that ACAE had potent protective effects against esophagitis due, in part, to its antioxidant properties as well as its opposite effect on some intracellular mediators.Graphical abstract (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Moringa oleifera phytochemicals protect the brain against experimental nicotine-induced neurobehavioral disturbances and cerebellar degeneration
This study was designed to determine the histomorphological and neurobehavioural changes in the cerebellum of Wistar rats following nicotine insult and how such injuries respond to Moringa intervention. Twenty-four adult male Wistar rats were divided into 4 groups. Group A and B were orally treated with normal saline and Moringa oleifera respectively for twenty-eight days; Group C was treated with nicotine while group D was treated orally with Moringa oleifera and intraperitoneally with nicotine for twenty-eight days. Animals were subjected to the open field test on the last day of treatment. 24 h after last day treatmen...
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Low CD4 cells and viral co-infection increase the risk of VaIN: Use of SCCA1 and Ki67 as diagno-prognostic biomarkers
This study evaluated the correlation of SCCA1, Ki67 and CD4 cell expressions and classified vaginal smears in individuals co-infected with Human immunodeficiency virus (HIV), Herpes simplex virus 2 (HSV2), Epstein Barr virus (EBV) and Human Papilloma virus (HPV). This crossectional study included 173 participants within the age range of 20–70 years. Vaginal smears were stained by Papanicolaou technique and classified into high-grade squamous cell intraepithelial lesion (HSIL), low-grade squamous intraepithelial lesion (LSIL), atypical squamous cells of undetermined significance (ASCUS) and negative for intraepithelial le...
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Glucocorticoid receptor activation selectively influence performance of Wistar rats in Y-maze
This study investigated the behavioral phenotypes characteristic of GR stimulation in male Wistar rats. Rats in each of the four groups of rats received one of the following treatments: distilled water (control) or one of three doses of dexamethasone (treatment) injected intraperitoneally for 7 days. The Rats were afterwards subjected to the Y maze, the elevated plus maze (EPM), the Morris water maze (MWM), and the novel object recognition (NOR) test. At the end of the study, the animals were anesthetized and neural activity from the prefrontal cortex recorded. Blood was collected via cardiac puncture to evaluate the lev...
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Rats exposed to 2.45 GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3
Publication date: March 2018Source: Pathophysiology, Volume 25, Issue 1Author(s): Rini Varghese, Anuradha Majumdar, Girish Kumar, Amit ShuklaAbstractIn recent years there has been a tremendous increase in use of Wi-Fi devices along with mobile phones, globally. Wi-Fi devices make use of 2.4 GHz frequency. The present study evaluated the impact of 2.45 GHz radiation exposure for 4 h/day for 45 days on behavioral and oxidative stress parameters in female Sprague Dawley rats. Behavioral tests of anxiety, learning and memory were started from day 38. Oxidative stress parameters were estimated in brain homog...
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
