Jobelyn suppresses hippocampal neuronal apoptosis and necrosis in experimental alcohol-induced brain stress
This study, therefore, evaluated the effect of Jobelyn® supplementation in ethanol-induced neurodegeneration of the hippocampus. Adult male rats received a regimen of ethanol or ethanol plus Jobelyn®, three times daily over four days. Histological results show that Jobelyn® supplementation significantly lowered neurodegeneration in the dentate gyrus, CA1 and CA3 areas. Furthermore, IHC studies show that Jobelyn® triggered an increased expression of p53 proteins in neurons of areas CA1 and CA3, with a reduction of p53 expression in the DG and also caused reduced expression of ɤ-enolase protein in these regions. These f...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
SPOP, ZEB-1 and E-cadherin expression in clear cell renal cell carcinoma (cc-RCC): Clinicopathological and prognostic significance
ConclusionPositive expression of SPOP& ZEB1 in addition to negative E- cadherin are associated with poor prognosis in cc-RCC patients. (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Correction of coagulopathy in thrombocytopenia and Glanzmann thrombasthenia models by fibrinogen and factor XIII as assessed by thromboelastometry
In conclusion, the created models may be useful in the development of new ways to correct the impaired coagulation potential in TCP and GT. (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Attenuation of cytotoxicity induced by tBHP in H9C2 cells by Bacopa monniera and Bacoside A
Publication date: June 2018Source: Pathophysiology, Volume 25, Issue 2Author(s): Mohan Manu T, T. Anand, Farhath KhanumAbstractCardiovascular diseases are one of the major global health issues leading to morbidity and mortality across the world. In the present study Bacopa monniera and its major bioactive component, Bacoside A (Bac-A) was used to evaluate its cytoprotective property in H9C2 cardiomyocytes against tBHP (150 μM) induced ROS-mediated oxidative stress and apoptosis. Our results implicate that pre-treatment with hydroalcoholic extract of Bacopa monniera (BME) and Bac-A (125 μg/ml and 6 μg/ml respective...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Ginger polyphenols attenuate cyclosporine-induced disturbances in kidney function: Potential application in adjuvant transplant therapy
Publication date: June 2018Source: Pathophysiology, Volume 25, Issue 2Author(s): Isiaka Ayofe Adekunle, Christian Eseigbe Imafidon, Ayowole Abraham Oladele, Abiodun Oladele AyokaAbstractCyclosporine (CYA), a common immuno-suppressant drug that is used in organ transplants, is associated with nephrotoxic effects. Scientific exploration of natural products of plant origin should be considered; especially, in a world with increasing prevalence of kidney diseases. Effects of ginger polyphenols (GP) in Wistar rats with CYA-induced perturbations in electrolyte balance and kidney function was determined. Fifty Wistar rats were re...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Calcitonin and Omega–3 Fatty Acids Exhibit Antagonistic and Non-Additive Effects in Experimental Diabetes
In conclusion, N-3 demonstrated antagonistic and non-additive actions with Sct. Moreover, the effects of the combined administration of Sct and N-3 were comparable to that of metformin; therefore, they might be considered as therapeutic alternatives in diabetes. (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
N-Acetylcysteine supplementation decreased brain lipid and protein oxidations produced by experimental homocysteine thiolactone exposure: Relevance to neurodegeneration
In this study, effects of HcyT treatment (500 mg/kg body weight/day in drinking water) for 6 weeks on serum Hcy levels and brain prooxidant-antioxidant balance were investigated in rats. The effect of N-acetylcysteine (NAC) treatment (1 g/kg body weight/day in chow) for 6 weeks on HcyT-induced neurotoxicity was evaluated. Reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), diene conjugate (DC), protein carbonyl (PC) and advanced oxidation protein products (AOPP) were determined in the brain tissue. Ferric reducing antioxidant power (FRAP) and non-protein sulfydryl groups (NPSH) levels as wel...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Consomic rats parental strains differ in sensory perception, pain developed following nerve injury and in IL-1 beta and IL-6 levels
Publication date: June 2018Source: Pathophysiology, Volume 25, Issue 2Author(s): Andrew Young, Mythili Kalladka, Archana Viswanath, Tal Zusman, Junad Khan (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Prediction of first-trimester preeclampsia: Relevance of the oxidative stress marker MDA in a combination model with PP-13, PAPP-A and beta-HCG
ConclusionCombined models consisting of various parameters of different origin, may provide better predictive outcomes, and oxidative markers should be considered in combination with other placental biomarkers in prediction of PE. (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Folic acid protects against experimental prenatal nicotine–induced cardiac injury by decreasing inflammatory changes, serum TNF and COX-2 expression
In conclusion, folic acid has a protective role against nicotine induced cardiac injury by reduction of COX-2 expression, decreasing TNF production and lipid peroxidation mediated cell injury. (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Inside front cover
Publication date: June 2018Source: Pathophysiology, Volume 25, Issue 2Author(s): (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Basal cell nevus syndrome (Gorlin syndrome): genetic insights, diagnostic challenges, and unmet milestones
Publication date: June 2018Source: Pathophysiology, Volume 25, Issue 2Author(s): Maryam Akbari, Harold Chen, Grace Guo, Zachary Legan, Ghali GhaliAbstractIn this article, we present three clinical case reports on Basal Cell Nevus Syndrome (Gorlin Syndrome). Gorlin syndrome is an inherited medical condition with challenges that manifest in multiple body systems and complicate early diagnosis. We examine the epidemiology of the disease and benefits of genetic testing, molecular pathophysiology, and advancement in the molecular-based therapy of Basal Cell Nevus syndrome. The goal of this paper is to shed light on both unmet c...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Increased glomerular Bax/Bcl2 ratio is positively correlated with glomerular sclerosis in lupus nephritis
ConclusionThe intrinsic pathway of apoptosis interfere in the pathogenesis of lupus glomerulonephritis. The balance between bax and bcl2 proteins might have a role in regulating the progression of glomeruli from proliferative to sclerotic state. (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Revisiting colorectal cancer animal model – An improved metastatic model for distal rectosigmoid colon carcinoma
We report a reproducible model, using human CRC cell lines (CL) (WiDr, LS1034, C2BBe1) injected (1 × 107 cells/animal) in RNU rats (n = 55) which underwent cecostomy and descending colostomy with mucosal-cutaneous fistula of the sigmoid colon. CL were characterized by immunohistochemistry: CK20, CDX2, P53, vimentin, Ki67, CD44, CD133, E-cadherin, β-catenin and CEA; cancer stem cells-immune system interaction was studied and tumor progression was assessed with nuclear medicine imaging (99mTc-MIBI).Animals developed locally invasive tumors and with WiDr neural invasion was registered. Cancer stem cells were detecte...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Genetic polymorphism of glutathione S-transferases: Relevance to neurological disorders
Publication date: Available online 11 June 2018Source: PathophysiologyAuthor(s): Sreenivasulu Dasari, Sailaja Gonuguntla, Muni Swamy Ganjayi, Suman Bukke, Basha Sreenivasulu, Balaji MerigaAbstractGlutathione S-tranferases (GSTs) are phase II drug metabolizing enzymes, they play crucial role in detoxification of environmental pollutants, carcinogens, drugs, xenobiotics and oxidative stress products. Genetic differences in expression and activity of GSTs are due to the existence of polymorphic alleles which encode them. Because of genetic polymorphism the GST activity has altered that lead to the increased susceptibility for...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
