Rats exposed to 2.45 GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3
Publication date: March 2018Source: Pathophysiology, Volume 25, Issue 1Author(s): Rini Varghese, Anuradha Majumdar, Girish Kumar, Amit ShuklaAbstractIn recent years there has been a tremendous increase in use of Wi-Fi devices along with mobile phones, globally. Wi-Fi devices make use of 2.4 GHz frequency. The present study evaluated the impact of 2.45 GHz radiation exposure for 4 h/day for 45 days on behavioral and oxidative stress parameters in female Sprague Dawley rats. Behavioral tests of anxiety, learning and memory were started from day 38. Oxidative stress parameters were estimated in brain homog...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Folate receptor α is associated with poor clinicopathological perspectives in breast carcinoma
ConclusionOur work demonstrates that FRα is over expressed in IDC compared to non-neoplastic breast tissue. Folate receptor α expression was associated with poor clinicopathological perspective. This work suggests that FRα may be an independent prognostic factor and supports the possibility of using FRα-targeted therapies of breast carcinoma. However, our work requires validation on larger cohort with correlation with survival data of patients. (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Protective effects of Artemisia campestris extract against gastric acid reflux-induced esophageal mucosa injuries
In conclusion, we suggested that ACAE had potent protective effects against esophagitis due, in part, to its antioxidant properties as well as its opposite effect on some intracellular mediators.Graphical abstract (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Moringa oleifera phytochemicals protect the brain against experimental nicotine-induced neurobehavioral disturbances and cerebellar degeneration
This study was designed to determine the histomorphological and neurobehavioural changes in the cerebellum of Wistar rats following nicotine insult and how such injuries respond to Moringa intervention. Twenty-four adult male Wistar rats were divided into 4 groups. Group A and B were orally treated with normal saline and Moringa oleifera respectively for twenty-eight days; Group C was treated with nicotine while group D was treated orally with Moringa oleifera and intraperitoneally with nicotine for twenty-eight days. Animals were subjected to the open field test on the last day of treatment. 24 h after last day treatmen...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Low CD4 cells and viral co-infection increase the risk of VaIN: Use of SCCA1 and Ki67 as diagno-prognostic biomarkers
This study evaluated the correlation of SCCA1, Ki67 and CD4 cell expressions and classified vaginal smears in individuals co-infected with Human immunodeficiency virus (HIV), Herpes simplex virus 2 (HSV2), Epstein Barr virus (EBV) and Human Papilloma virus (HPV). This crossectional study included 173 participants within the age range of 20–70 years. Vaginal smears were stained by Papanicolaou technique and classified into high-grade squamous cell intraepithelial lesion (HSIL), low-grade squamous intraepithelial lesion (LSIL), atypical squamous cells of undetermined significance (ASCUS) and negative for intraepithelial le...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Glucocorticoid receptor activation selectively influence performance of Wistar rats in Y-maze
This study investigated the behavioral phenotypes characteristic of GR stimulation in male Wistar rats. Rats in each of the four groups of rats received one of the following treatments: distilled water (control) or one of three doses of dexamethasone (treatment) injected intraperitoneally for 7 days. The Rats were afterwards subjected to the Y maze, the elevated plus maze (EPM), the Morris water maze (MWM), and the novel object recognition (NOR) test. At the end of the study, the animals were anesthetized and neural activity from the prefrontal cortex recorded. Blood was collected via cardiac puncture to evaluate the lev...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Oral phenytoin protects against experimental cyclophosphamide-chemotherapy induced hair loss
This study showed that oral phenytoin can suppress hair loss due to CYP therapy in rats; however, further studies are needed to evaluate its potential application in chemotherapy-induced alopecia. (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
One-year recombinant growth hormone therapy does not improve hemoglobin state and morphology of erythrocytes in growth hormone deficient children
Publication date: March 2018Source: Pathophysiology, Volume 25, Issue 1Author(s): Maria Pankratova, Alexander Yusipovich, Maria Vorontsova, Evgenia Parshina, Svetlana Bochkareva, Alexander Cherkashin, Adil Baizhumanov, Margarita Silicheva, Tatyana Shiryaeva, Georgy Maksimov, Valentina PeterkovaAbstractAn increase in growth rates of children suffering from growth hormone deficiency (GHD) subjected to recombinant growth hormone treatment (rGHT) was shown to be accompanied by acceleration of metabolic processes that may stimulate oxygen consumption in various organs and tissues. Therefore, oxygen-transporting properties of RB...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Gastroesophageal reflux disease: A clinical overview for primary care physicians
ConclusionGERD is one of the most common diagnoses made by gastroenterologists and primary care physicians. It is important to recognize the typical and atypical presentations of GERD. This paper helps primary care physicians understand the disease’s pathophysiology, and when, how, and with what to treat GERD before referring patients to gastroenterologists or surgeons. (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Inside front cover
Publication date: March 2018Source: Pathophysiology, Volume 25, Issue 1Author(s): (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Chitin, chitinases, and chitin lectins: Emerging roles in human pathophysiology
Publication date: Available online 6 March 2018Source: PathophysiologyAuthor(s): Sally Ziatabar, Jennifer Zepf, Sushama Rich, Ben T. Danielson, Paul I. Bollyky, Robert SternAbstractChitin is a simple β-linked repeating sugar polymer prominent in the building block structures of a wide variety of organisms, from the yeast cell wall to the exoskeleton and shells of arthropods and other forms of invertebrate life. It had previously been assumed that vertebrates did not contain chitins. However, chitin and chitinases are now documented to occur in vertebrate tissues. Chitin, chitinases and particularly chitinase-like proteins...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Food additives, food and the concept of ‘food addiction’: Is stimulation of the brain reward circuit by food sufficient to trigger addiction?
Publication date: Available online 12 April 2018Source: PathophysiologyAuthor(s): A.Y. Onaolapo, O.J. OnaolapoAbstractIn the last few years, the concept of ‘food addiction’ has continued to gain popularity, with human and animal studies demonstrating the differential effects of foods that are high in fat, sugar or protein on appetite, satiety, eating behaviour and the development of food addiction. However, a number of studies have disputed the occurrence of food addiction in humans. Questions have also arisen regarding the possible impacts that food additives may have on the development of food addiction or eating dis...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
The pathophysiology of myocardial infarction-induced heart failure
Publication date: Available online 18 April 2018Source: PathophysiologyAuthor(s): Daniele Gabriel-CostaAbstractHeart failure (HF) is a multifactorial disorder and is usually the end stage of many cardiovascular diseases (CVD). HF presents one of the highest morbidity and mortality indices worldwide and high costs to public health organizations. Myocardial infarction (MI) is the most prevalent CVD in the Western world and leads to HF when its management is inadequate. It has a destructive potential for heart cells and abruptly reduces the cardiac output, a clinical condition known as heart dysfunction that might progress to...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Mimosa pudica Protects the Testes Against Cadmium-Induced Inflammation and Oligospermia: Potential Benefits in Treatment of Heavy Metal Toxicity
This study demonstrates that M. pudica has potential protective and restorative properties on the histoarchitecture of the testes of cadmium-treated rats. (Source: Pathophysiology)
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
Kolaviron protects the brain in cuprizone-induced model of experimental multiple sclerosis via enhancement of intrinsic antioxidant mechanisms: Possible therapeutic applications?
Publication date: Available online 27 April 2018Source: PathophysiologyAuthor(s): Gabriel Olaiya Omotoso, Ileje Inelo Ukwubile, Leviticus Arietarhire, Fatima Sulaimon, Ismail Temitayo GbadamosiAbstractMultiple sclerosis is a demyelinating condition of the central nervous system which commonly affects young adults. Kolaviron, a biflavonoid isolate of Garcinia kola, has been used in experimental studies which explored its anti-oxidative, anti-inflammatory and anti-genotoxic properties. This work was aimed at unraveling the possible ameliorative effect of kolaviron on cuprizone-induced demyelination in the prefrontal cortices...
Source: Pathophysiology - July 10, 2018 Category: Pathology Source Type: research
