Rats exposed to 2.45GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3
Publication date: Available online 14 November 2017 Source:Pathophysiology Author(s): Rini Varghese, Anuradha Majumdar, Girish Kumar, Amit Shukla In recent years there has been a tremendous increase in use of Wi-Fi devices along with mobile phones, globally. Wi-Fi devices make use of 2.4GHz frequency. The present study evaluated the impact of 2.45GHz radiation exposure for 4 hours/day for 45days on behavioral and oxidative stress parameters in female Sprague Dawley rats. Behavioral tests of anxiety, learning and memory were started from day 38. Oxidative stress parameters were estimated in brain homogenates after sac...
Source: Pathophysiology - November 15, 2017 Category: Pathology Source Type: research
One-year recombinant growth hormone therapy does not improve hemoglobin state and morphology of erythrocytes in growth hormone deficient children
Publication date: Available online 7 October 2017 Source:Pathophysiology Author(s): Maria Pankratova, Alexander Yusipovich, Maria Vorontsova, Evgenia Parshina, Svetlana Bochkareva, Alexander Cherkashin, Adil Baizhumanov, Margarita Silicheva, Shiryaeva Tatyana, Georgy Maksimov, Valentina Peterkova An increase in growth rates of children suffering from growth hormone deficiency (GHD) subjected to recombinant growth hormone treatment (rGHT) was shown to be accompanied by acceleration of metabolic processes that may stimulate oxygen consumption in various organs and tissues. Therefore, oxygen-transporting properti...
Source: Pathophysiology - October 8, 2017 Category: Pathology Source Type: research
Reperfusion therapy —what’s with the obstructed, leaky and broken capillaries?
Publication date: Available online 21 September 2017 Source:Pathophysiology Author(s): D. Neil Granger, Peter R. Kvietys Microvascular dysfunction is well established as an early and rate-determining factor in the injury response of tissues to ischemia and reperfusion (I/R). Severe endothelial cell dysfunction, which can develop without obvious morphological cell injury, is a major underlying cause of the microvascular abnormalities that accompany I/R. While I/R-induced microvascular dysfunction is manifested in different ways, two responses that have received much attention in both the experimental and clinical settin...
Source: Pathophysiology - September 22, 2017 Category: Pathology Source Type: research
Update on food safety of monosodium L-glutamate (MSG)
Conclusion Based on the above observations (A − I), high quality MSG is safe for all life-cycle stages without respect to ethnic origin or culinary background. MSG researchers are advised to employ appropriate scientific methodologies, consider glutamate metabolism and its normal food use before extrapolating pharmacological rodent studies to humans. (Source: Pathophysiology)
Source: Pathophysiology - September 19, 2017 Category: Pathology Source Type: research
Rosemary (Rosmarinus Officinalis) Essential oil Components Exhibit Anti-Hyperglycemic, Anti-Hyperlipidemic and Antioxidant Effects in Experimental Diabetes
Conclusions We propose that Rosmarinus officinalis essential oils exhibit protective effects in alloxan-induced hyperglycaemia as well as protecting against liver and kidney oxidative stress in rats, reflecting its antioxidant properties. (Source: Pathophysiology)
Source: Pathophysiology - September 14, 2017 Category: Pathology Source Type: research
Garlic extract increases non-clipped kidney tubular natriuresis and diuresis in the 2-kidney, 1-clip rat model: Significance in hypertension
Publication date: Available online 12 September 2017 Source:Pathophysiology Author(s): Khaled K. Al-Qattan, Martha Thomson, Muslim Ali (Source: Pathophysiology)
Source: Pathophysiology - September 13, 2017 Category: Pathology Source Type: research
Gastroesophageal reflux disease: A clinical overview for primary care physicians
Conclusion GERD is one of the most common diagnoses made by gastroenterologists and primary care physicians. It is important to recognize the typical and atypical presentations of GERD. This paper helps primary care physicians understand the disease’s pathophysiology, and when, how, and with what to treat GERD before referring patients to gastroenterologists or surgeons. (Source: Pathophysiology)
Source: Pathophysiology - September 11, 2017 Category: Pathology Source Type: research
Obstructive Sleep Apnea: Influence of Hypertension on Adiponectin, Inflammatory Markers and Dyslipidemia
In conclusion, the biochemical findings of this study demonstrate predominantly low adiponectin levels, increased levels of inflammatory markers, and atherogenic lipid profiles in OSA patients with HT compared with those of the other patients studied. This highlights the possible contributing role of these factors to the pathogenesis of HT as a common cardiovascular complication in OSA patients. (Source: Pathophysiology)
Source: Pathophysiology - September 2, 2017 Category: Pathology Source Type: research
The Garcinia kola biflavonoid kolaviron attenuates experimental hepatotoxicity induced by diclofenac
In conclusion, kolaviron appears to be as effective as Livolin in attenuating DCLF-induced hepatotoxicity in rats. However, high doses of kolaviron seem to cause damage to the liver. (Source: Pathophysiology)
Source: Pathophysiology - August 17, 2017 Category: Pathology Source Type: research
Two year follow-up of Crohn ’s patients substituted to certolizumab anti-TNFa therapy: SAVANT 2
Publication date: Available online 9 August 2017 Source:Pathophysiology Author(s): Andrew Motlis, Moheb Boktor, Paul Jordan, Urska Cvek, Marjan Trutschl, J. Steven Alexander (Source: Pathophysiology)
Source: Pathophysiology - August 10, 2017 Category: Pathology Source Type: research
Irinotecan chemotherapy-induced intestinal oxidative stress: Underlying causes of disturbed mucosal water and electrolyte transport
In conclusion, the data suggest that irinotecan caused a gastrointestinal stress via oxidative stress-induced disturbances in water and electrolyte transport in the intestinal mucosa in rats. Graphical abstract (Source: Pathophysiology)
Source: Pathophysiology - July 24, 2017 Category: Pathology Source Type: research
Diabetic Retinopathy: Breaking the Barrier
Publication date: Available online 12 July 2017 Source:Pathophysiology Author(s): Randa S. Eshaq, Alaa M.Z. Aldalati, J. Steven Alexander, Norman R. Harris Diabetic retinopathy (DR) remains a major complication of diabetes and a leading cause of blindness among adults worldwide. DR is a progressive disease affecting both type I and type II diabetic patients at any stage of the disease, and targets the retinal microvasculature. DR results from multiple biochemical, molecular and pathophysiological changes to the retinal vasculature, which affect both microcirculatory functions and ultimately photoreceptor function. Se...
Source: Pathophysiology - July 13, 2017 Category: Pathology Source Type: research
Experimental maternal treatment with dexamethasone during lactation induces neonatal testicular and epididymal oxidative stress; Implications for early postnatal exposure
In conclusion, maternal treatment with dexamethasone during the first two weeks of lactation and throughout lactation may lead to increase in oxidative stress in the testis and epididymis of the male offspring of Wistar rats. (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2017 Category: Pathology Source Type: research
A novel golgi-cox staining method for detecting and characterizing roles of the hepatic stellate cells in liver injury
Publication date: Available online 30 June 2017 Source:Pathophysiology Author(s): Ma. de Jesús Gómez Villalobos, Susana Vidrio, Ruth Giles López, Gabriel Flores Gómez, Victoria Chagoya de Sánchez The aim of this study was to investigate the utility of the Golgi-Cox method to characterize the distribution and morphological changes of the hepatic stellate cells (HSCs) in CCl4 liver damaged rats. Six-week-old male Wistar rats were injected with CCl4 for ten weeks. The livers were processed with the Golgi-Cox method, reticuline, and Massońs Trichrome stains, and analyzed under light microscopy. Histological evalua...
Source: Pathophysiology - July 1, 2017 Category: Pathology Source Type: research
Sausage tree (Kigelia africana) flavonoid extract is neuroprotective in AlCl3-induced experimental Alzheimer ’s disease
In this study, the neuroprotective properties of a methanol extract of the leaves of Kigelia africana (KAE) and its flavonoid-rich fraction (FKAE) in aluminum chloride (AlCl3)-induced experimental AD was evaluated. Symptoms mimicking AD were induced in male Sprague Dawley rats by administering 17mg/kg AlCl3, orally, for six consecutive weeks. Pretreatment of animals with 50 and 100mg/kg KAE or FKAE for two weeks, followed by their co-administration with AlCl3 for a further four weeks ameliorated neurological deficits, cerebral oxidative stress, neurochemical disturbances and histoarchitectural alterations caused by AlCl3 i...
Source: Pathophysiology - June 29, 2017 Category: Pathology Source Type: research
