One-year recombinant growth hormone therapy does not improve hemoglobin state and morphology of erythrocytes in growth hormone deficient children
Publication date: March 2018Source: Pathophysiology, Volume 25, Issue 1Author(s): Maria Pankratova, Alexander Yusipovich, Maria Vorontsova, Evgenia Parshina, Svetlana Bochkareva, Alexander Cherkashin, Adil Baizhumanov, Margarita Silicheva, Tatyana Shiryaeva, Georgy Maksimov, Valentina PeterkovaAbstractAn increase in growth rates of children suffering from growth hormone deficiency (GHD) subjected to recombinant growth hormone treatment (rGHT) was shown to be accompanied by acceleration of metabolic processes that may stimulate oxygen consumption in various organs and tissues. Therefore, oxygen-transporting properties of RB...
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Gastroesophageal reflux disease: A clinical overview for primary care physicians
ConclusionGERD is one of the most common diagnoses made by gastroenterologists and primary care physicians. It is important to recognize the typical and atypical presentations of GERD. This paper helps primary care physicians understand the disease’s pathophysiology, and when, how, and with what to treat GERD before referring patients to gastroenterologists or surgeons. (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Inside front cover
Publication date: March 2018Source: Pathophysiology, Volume 25, Issue 1Author(s): (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Chitin, chitinases, and chitin lectins: Emerging roles in human pathophysiology
Publication date: Available online 6 March 2018Source: PathophysiologyAuthor(s): Sally Ziatabar, Jennifer Zepf, Sushama Rich, Ben T. Danielson, Paul I. Bollyky, Robert SternAbstractChitin is a simple β-linked repeating sugar polymer prominent in the building block structures of a wide variety of organisms, from the yeast cell wall to the exoskeleton and shells of arthropods and other forms of invertebrate life. It had previously been assumed that vertebrates did not contain chitins. However, chitin and chitinases are now documented to occur in vertebrate tissues. Chitin, chitinases and particularly chitinase-like proteins...
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Food additives, food and the concept of ‘food addiction’: Is stimulation of the brain reward circuit by food sufficient to trigger addiction?
Publication date: Available online 12 April 2018Source: PathophysiologyAuthor(s): A.Y. Onaolapo, O.J. OnaolapoAbstractIn the last few years, the concept of ‘food addiction’ has continued to gain popularity, with human and animal studies demonstrating the differential effects of foods that are high in fat, sugar or protein on appetite, satiety, eating behaviour and the development of food addiction. However, a number of studies have disputed the occurrence of food addiction in humans. Questions have also arisen regarding the possible impacts that food additives may have on the development of food addiction or eating dis...
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
The pathophysiology of myocardial infarction-induced heart failure
Publication date: Available online 18 April 2018Source: PathophysiologyAuthor(s): Daniele Gabriel-CostaAbstractHeart failure (HF) is a multifactorial disorder and is usually the end stage of many cardiovascular diseases (CVD). HF presents one of the highest morbidity and mortality indices worldwide and high costs to public health organizations. Myocardial infarction (MI) is the most prevalent CVD in the Western world and leads to HF when its management is inadequate. It has a destructive potential for heart cells and abruptly reduces the cardiac output, a clinical condition known as heart dysfunction that might progress to...
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Mimosa pudica Protects the Testes Against Cadmium-Induced Inflammation and Oligospermia: Potential Benefits in Treatment of Heavy Metal Toxicity
This study demonstrates that M. pudica has potential protective and restorative properties on the histoarchitecture of the testes of cadmium-treated rats. (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Kolaviron protects the brain in cuprizone-induced model of experimental multiple sclerosis via enhancement of intrinsic antioxidant mechanisms: Possible therapeutic applications?
Publication date: Available online 27 April 2018Source: PathophysiologyAuthor(s): Gabriel Olaiya Omotoso, Ileje Inelo Ukwubile, Leviticus Arietarhire, Fatima Sulaimon, Ismail Temitayo GbadamosiAbstractMultiple sclerosis is a demyelinating condition of the central nervous system which commonly affects young adults. Kolaviron, a biflavonoid isolate of Garcinia kola, has been used in experimental studies which explored its anti-oxidative, anti-inflammatory and anti-genotoxic properties. This work was aimed at unraveling the possible ameliorative effect of kolaviron on cuprizone-induced demyelination in the prefrontal cortices...
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Jobelyn suppresses hippocampal neuronal apoptosis and necrosis in experimental alcohol-induced brain stress
This study, therefore, evaluated the effect of Jobelyn® supplementation in ethanol-induced neurodegeneration of the hippocampus. Adult male rats received a regimen of ethanol or ethanol plus Jobelyn®, three times daily over four days. Histological results show that Jobelyn® supplementation significantly lowered neurodegeneration in the dentate gyrus, CA1 and CA3 areas. Furthermore, IHC studies show that Jobelyn® triggered an increased expression of p53 proteins in neurons of areas CA1 and CA3, with a reduction of p53 expression in the DG and also caused reduced expression of ɤ-enolase protein in these regions. These f...
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
SPOP, ZEB-1 and E-cadherin expression in clear cell renal cell carcinoma (cc-RCC): Clinicopathological and prognostic significance
ConclusionPositive expression of SPOP& ZEB1 in addition to negative E- cadherin are associated with poor prognosis in cc-RCC patients. (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Correction of coagulopathy in thrombocytopenia and Glanzmann thrombasthenia models by fibrinogen and factor XIII as assessed by thromboelastometry
In conclusion, the created models may be useful in the development of new ways to correct the impaired coagulation potential in TCP and GT. (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Attenuation of cytotoxicity induced by tBHP in H9C2 cells by Bacopa monniera and Bacoside A
Publication date: June 2018Source: Pathophysiology, Volume 25, Issue 2Author(s): Mohan Manu T, T. Anand, Farhath KhanumAbstractCardiovascular diseases are one of the major global health issues leading to morbidity and mortality across the world. In the present study Bacopa monniera and its major bioactive component, Bacoside A (Bac-A) was used to evaluate its cytoprotective property in H9C2 cardiomyocytes against tBHP (150 μM) induced ROS-mediated oxidative stress and apoptosis. Our results implicate that pre-treatment with hydroalcoholic extract of Bacopa monniera (BME) and Bac-A (125 μg/ml and 6 μg/ml respective...
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Prediction of first-trimester preeclampsia: Relevance of the oxidative stress marker MDA in a combination model with PP-13, PAPP-A and beta-HCG
ConclusionCombined models consisting of various parameters of different origin, may provide better predictive outcomes, and oxidative markers should be considered in combination with other placental biomarkers in prediction of PE. (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Folic acid protects against experimental prenatal nicotine–induced cardiac injury by decreasing inflammatory changes, serum TNF and COX-2 expression
In conclusion, folic acid has a protective role against nicotine induced cardiac injury by reduction of COX-2 expression, decreasing TNF production and lipid peroxidation mediated cell injury. (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
Consomic rats parental strains differ in sensory perception, pain developed following nerve injury and in IL-1 beta and IL-6 levels
Publication date: June 2018Source: Pathophysiology, Volume 25, Issue 2Author(s): Andrew Young, Mythili Kalladka, Archana Viswanath, Tal Zusman, Junad Khan (Source: Pathophysiology)
Source: Pathophysiology - July 5, 2018 Category: Pathology Source Type: research
