H. pylori Infection Increases Gastric Mucosal COX2 and mTOR Expression in Chronic Gastritis: Implications for Cancer Progression?

Conclusion These findings suggest that there is a positive feedback loop between H. pylori infection and the pathogenesis of gastric mucosal changes. Also, mTOR and COX2 over expression cause premalignant changes and subsequent tumor occurrence. This may help in providing innovative approaches for the detection of patients-with a higher chance of cancer development, and in trying to introduce effective therapy preventing tumor occurrence, or even using these molecular markers as potential targets for tumors treatment strategies.
Source: Pathophysiology - Category: Pathology Source Type: research