Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Giorgio Bergamini, Jonas Mechtersheimer, Damiano Azzinnari, Hannes Sigrist, Michaela Buerge, Robert Dallmann, Robert Freije, Afroditi Kouraki, Jolanta Opacka-Juffry, Erich Seifritz, Boris Ferger, Tobias Suter, Christopher R. PryceAbstractPsychosocial stress is a major risk factor for depression, stress leads to peripheral and central immune activation, immune activation is associated with blunted dopamine (DA) neural function, DA function underlies reward interest, and reduced reward interest is a core symptom of depression. These states migh...
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Jessica L. Bolton, Christina M. Ruiz, Neggy Rismanchi, Gissell A. Sanchez, Erik Castillo, Jeff Huang, Christopher Cross, Tallie Z. Baram, Stephen V. MahlerAbstractEarly-life adversity increases the risk for emotional disorders such as depression and schizophrenia. Anhedonia, thought to be a core feature of these disorders, is provoked by our naturalistic rodent model of childhood adversity (i.e., rearing pups for one week in cages with limited bedding and nesting, LBN). Drug use and addiction are highly comorbid with psychiatric disorders fea...
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
The relationship between stress and Alzheimer's disease
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Nicholas J. JusticeAbstractStress is critically involved in the development and progression of disease. From the stress of undergoing treatments to facing your own mortality, the physiological processes that stress drives have a serious detrimental effect on the ability to heal, cope and maintain a positive quality of life. This is becoming increasingly clear in the case of neurodegenerative diseases. Neurodegenerative diseases involve the devastating loss of cognitive and motor function which is stressful in itself, but can also disrupt neur...
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
Distinct CCL2, CCL5, CCL11, CCL27, IL-17, IL-6, BDNF serum profiles correlate to different job-stress outcomes
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Alessio Polacchini, Damiano Girardi, Alessandra Falco, Nunzia Zanotta, Manola Comar, Nicola Alberto De Carlo, Enrico TongiorgiAbstractChronic psychosocial stress at workplace is an important factor in the development of physical and mental illness. Objective biological measures of chronic stress are still lacking, but inflammatory response and growth factors are increasingly considered as potential stress biomarkers. Therefore, we investigated the relationship between psychophysical strain and serum levels of 48 chemokines, cytokines and grow...
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Lianne Hoeijmakers, Sylvie L. Lesuis, Harm Krugers, Paul J. Lucassen, Aniko KorosiAbstractStress experienced early in life (ES), in the form of childhood maltreatment, maternal neglect or trauma, enhances the risk for cognitive decline in later life. Several epidemiological studies have now shown that environmental and adult life style factors influence AD incidence or age-of-onset and early-life environmental conditions have attracted attention in this respect. There is now emerging interest in understanding whether ES impacts the risk to de...
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
