Interactions between stress and physical activity on Alzheimer's disease pathology
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Carla M. Yuede, Benjamin F. Timson, Jane C. Hettinger, Kayla M. Yuede, Hannah M. Edwards, Justin E. Lawson, Scott D. Zimmerman, John R. CirritoAbstractPhysical activity and stress are both environmental modifiers of Alzheimer's disease (AD) risk. Animal studies of physical activity in AD models have largely reported positive results, however benefits are not always observed in either cognitive or pathological outcomes and inconsistencies among findings remain. Studies using forced exercise may increase stress and mitigate some of the benefit ...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Two models of inescapable stress increase tph2 mRNA expression in the anxiety-related dorsomedial part of the dorsal raphe nucleus
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Nina C. Donner, Kenneth H. Kubala, James E. Hassell Jr., Margaret W. Lieb, Kadi T. Nguyen, Jared D. Heinze, Robert C. Drugan, Steven F. Maier, Christopher A. LowryAbstractExpression of TPH2, the rate-limiting enzyme for brain serotonin synthesis, is elevated in the dorsal raphe nucleus (DR) of depressed suicide victims. One hypothesis is that this increase in TPH2 expression is stress-induced. Here, we used an established animal model to address whether exposure to an acute stressor, inescapable tail shock (IS), increases tph2 mRNA and Tph2 p...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
What does the Fos say? Using Fos-based approaches to understand the contribution of stress to substance use disorders
Publication date: Available online 2 June 2018Source: Neurobiology of StressAuthor(s): Jayme R. McReynolds, John P. Christianson, Jordan M. Blacktop, John R. MantschAbstractDespite extensive research efforts, drug addiction persists as a largely unmet medical need. Perhaps the biggest challenge for treating addiction is the high rate of recidivism. While many factors can promote relapse in abstinent drug users, the contribution of stress is particularly problematic, as stress is uncontrollable and pervasive in the lives of those struggling with addiction. Thus, understanding the neurocircuitry that underlies the influence ...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Alternations in functional connectivity of amygdalar subregions under acute social stress
Publication date: Available online 19 June 2018Source: Neurobiology of StressAuthor(s): Jingjing Chang, Rongjun YuAbstractThe amygdala has long been considered a vital region involved in acute and chronic stress responses. Extensive evidences from animal and human studies suggest that the functional connectivity of amygdalar subnuclei (basolateral amygdala (BLA), centromedial amygdala (CMA) and superficial amygdala (SFA)) undergo specific alterations in stress-related psychopathology. However, whether and how intrinsic functional connectivity within the amygdalar subcomponents is differently altered in the aftermath of an ...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Mapping stress networks using functional magnetic resonance imaging in awake animals
Publication date: Available online 4 July 2018Source: Neurobiology of StressAuthor(s): David Dopfel, Nanyin ZhangAbstractThe neurobiology of stress is studied through behavioral neuroscience, endocrinology, neuronal morphology and neurophysiology. There is a shift in focus toward progressive changes throughout stress paradigms and individual susceptibility to stress that requires methods that allow for longitudinal study design and study of individual differences in stress response. Functional magnetic resonance imaging (fMRI), with the advantages of noninvasiveness and a large field of view, can be used for functionally m...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Effects of high fat or high sucrose diet on behavioral-response to social defeat stress in mice
Publication date: November 2018Source: Neurobiology of Stress, Volume 9Author(s): Deseree M. Eudave, McKenna N. BeLow, Elizabeth I. FlandreauAbstractStress increases risk for psychopathology, and diet may moderate the impact of stress on mental health. A “Western” diet has been linked to psychopathology in humans; animal studies also show that diet can influence negative valence behavior in the presence or absence of stress, but findings are inconsistent. Contradictions in existing studies may result from differences in macronutrient content of diets and presence of metabolic syndrome. The present study exposed mice to...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress
Publication date: November 2018Source: Neurobiology of Stress, Volume 9Author(s): Kanchan Bisht, Kaushik Sharma, Marie-Ève TremblayAbstractMicroglia are the predominant immune cells of the central nervous system (CNS) that exert key physiological roles required for maintaining CNS homeostasis, notably in response to chronic stress, as well as mediating synaptic plasticity, learning and memory. The repeated exposure to stress confers a higher risk of developing neurodegenerative diseases including sporadic Alzheimer's disease (AD). While microglia have been causally linked to amyloid beta (Aβ) accumulation, tau pathology,...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
c-Fos mapping of brain regions activated by multi-modal and electric foot shock stress
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Xiaoxiao Lin, Christy A. Itoga, Sharif Taha, Ming H. Li, Ryan Chen, Kirolos Sami, Fulvia Berton, Walter Francesconi, Xiangmin XuAbstractReal-world stressors are complex and multimodal, involving physical, psychological, and social dimensions. However, the brain networks that mediate stress responses to these stimuli need to be further studied. We used c-Fos mapping in mice to characterize brain circuits activated by exposure to a single episode of multimodal stress (MMS), and compared these to circuits activated by electric foot shocks (EFS)....
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
Network-based approaches to examining stress in the adolescent brain
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Tiffany C. Ho, Emily L. Dennis, Paul M. Thompson, Ian H. GotlibAbstractExposure to stress, particularly in periods of rapid brain maturation such as adolescence, can profoundly influence developmental processes that undergird the organization of structural and functional brain networks and that may mediate the association between stressful experiences and maladaptive outcomes. While studies in translational developmental neuroscience often focus on how specific brain regions or targeted connections are altered by stress and psychiatric diseas...
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
Roadmap for optimizing the clinical utility of emotional stress paradigms in human neuroimaging research
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Timothy J. McDermott, Namik Kirlic, Robin L. AupperleAbstractThe emotional stress response is relevant to a number of psychiatric disorders, including posttraumatic stress disorder (PTSD) in particular. Research using neuroimaging methods such as functional magnetic resonance imaging (fMRI) to probe stress-related neural processing have provided some insights into psychiatric disorders. Treatment providers and individual patients would benefit from clinically useful fMRI paradigms that provide information about patients’ current brain state...
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
Editorial
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
The effects of acute stress on the calibration of persistence
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Karolina M. Lempert, Joseph T. McGuire, Danielle B. Hazeltine, Elizabeth A. Phelps, Joseph W. KableAbstractPeople frequently fail to wait for delayed rewards after choosing them. These preference reversals are sometimes thought to reflect self-control failure. Other times, however, continuing to wait for a delayed reward may be counterproductive (e.g., when reward timing uncertainty is high). Research has demonstrated that people can calibrate how long to wait for rewards in a given environment. Thus, the role of self-control might be to inte...
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
Differential impact of Met receptor gene interaction with early-life stress on neuronal morphology and behavior in mice
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Hanke Heun-Johnson, Pat LevittAbstractEarly adversity in childhood increases the risk of anxiety, mood, and post-traumatic stress disorders in adulthood, and specific gene-by-environment interactions may increase risk further. A common functional variant in the promoter region of the gene encoding the human MET receptor tyrosine kinase (rs1858830 ‘C’ allele) reduces expression of MET and is associated with altered cortical circuit function and structural connectivity. Mice with reduced Met expression exhibit changes in anxiety-like and co...
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
Maternal separation stress leads to resilience against neuropathic pain in adulthood
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Julien Genty, Milène Tetsi Nomigni, Fernand Anton, Ulrike HaneschAbstractEarly life stress (ELS) leads to a permanent reprogramming of biochemical stress response cascades that may also be relevant for the processing of chronic pain states such as neuropathy. Despite clinical evidence, little is known about ELS-related vulnerability for neuropathic pain and the possibly underlying etiology.In the framework of experimental studies aimed at investigating the respective relationships we used the established ELS model of maternal separation (MS)...
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
Sex differences after chronic stress in the expression of opioid-, stress- and neuroplasticity-related genes in the rat hippocampus
In conclusion, modest sex- and regional-differences are seen in expression of the opioid receptor genes, as well as genes involved in stress and plasticity responses in the hippocampus following CIS. (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research
