Editorial Board
Publication date: November 2018Source: Neurobiology of Stress, Volume 9Author(s): (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - November 11, 2018 Category: Neuroscience Source Type: research
Effect of a multistrain probiotic (Lactoflorene® Plus) on inflammatory parameters and microbiota composition in subjects with stress-related symptoms
Publication date: Available online 7 November 2018Source: Neurobiology of StressAuthor(s): Sara Soldi, Sara Carlotta Tagliacarne, Chiara Valsecchi, Simone Perna, Mariangela Rondanelli, Luigi Ziviani, Stefano Milleri, Ariella Annoni, Annamaria CastellazziAbstractStress affects the immune system and intestinal microbiota composition and can lead to imbalance between pro- and anti-inflammatory cytokines or to uncontrolled production of cytokines. The effect of emotional stress on secretory IgA levels also indicates that stress decreases mucosal integrity. Our aim was to evaluate whether a probiotic product (Lactoflorene® Plu...
Source: Neurobiology of Stress - November 8, 2018 Category: Neuroscience Source Type: research
Brain activity associated with social exclusion overlaps with drug-related frontal-striatal circuitry in cocaine users: A pilot study
ConclusionCocaine dependent individuals have an amplified brain response to social exclusion stress in cortical regions associated with emotional regulation, arousal, craving and perception of physical pain. These data suggest that there may be a neurological basis for the well-established relationship between social stress and addiction. (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - October 31, 2018 Category: Neuroscience Source Type: research
Leveraging translational neuroscience to inform early intervention and addiction prevention for children exposed to early life stress
Publication date: Available online 26 October 2018Source: Neurobiology of StressAuthor(s): Leslie E. Roos, Sarah Horn, Elliot T. Berkman, Katherine Pears, Philip A. FisherAbstractSubstance use and addiction are disproportionately experienced by individuals with a history of exposure to early life stress (ELS), such as maltreatment, domestic violence and parent psychopathology. Unfortunately, extant interventions have mixed effectiveness at improving outcome trajectories for ELS-exposed children, who are often underserved by evidenced-based programs. Here, we employ a translational neuroscience framework to delineate how ne...
Source: Neurobiology of Stress - October 26, 2018 Category: Neuroscience Source Type: research
Elimination of vesicular zinc alters the behavioural and neuroanatomical effects of social defeat stress in mice
We examined how chronic stress, induced by repeated social defeat, affects mice that lack vesicular zinc due to genetic deletion of zinc transporter 3 (ZnT3). These mice, unlike wild type mice, did not become socially avoidant of a novel conspecific, suggesting resilience to stress. However, they showed enhanced sensitivity to the potentiating effect of stress on cued fear memory. Thus, the contribution of vesicular zinc to stress susceptibility is not straightforward. Stress also increased anxiety-like behaviour but produced no deficits in a spatial Y-maze test. We found no evidence that microglial activation or hippocamp...
Source: Neurobiology of Stress - October 22, 2018 Category: Neuroscience Source Type: research
Diminished positive affect and traumatic stress: A biobehavioral review and commentary on trauma affective neuroscience
Publication date: Available online 21 October 2018Source: Neurobiology of StressAuthor(s): Gregory A. FonzoAbstractPost-traumatic stress manifests in disturbed affect and emotion, including exaggerated severity and frequency of negative valence emotions, e.g., fear, anxiety, anger, shame, and guilt. However, another core feature of common post-trauma psychopathologies, i.e. post-traumatic stress disorder (PTSD) and major depression, is diminished positive affect, or reduced frequency and intensity of positive emotions and affective states such as happiness, joy, love, interest, and desire/capacity for interpersonal affilia...
Source: Neurobiology of Stress - October 21, 2018 Category: Neuroscience Source Type: research
Sleep and circadian rhythm disruption and stress intersect in Alzheimer's disease
Publication date: Available online 17 October 2018Source: Neurobiology of StressAuthor(s): Trongha Phan, Roneil MalkaniAbstractThe Alzheimer's disease (AD) was discovered and the pathological hallmarks were revealed more than a century ago. Subsequently, many remarkable discoveries and breakthroughs provided us with mechanistic insights into the pathogenesis of AD. The identification of the molecular underpinning of the disease not only provided the framework of AD pathogenesis but also targets for therapeutic inventions. Despite all the initial successes, no effective treatment for AD has emerged yet as all the late stage...
Source: Neurobiology of Stress - October 17, 2018 Category: Neuroscience Source Type: research
A review of nonhuman primate models of early life stress and adolescent drug abuse
Publication date: Available online 21 September 2018Source: Neurobiology of StressAuthor(s): Alison G.P. Wakeford, Elyse M. Morin, Sara N. Bramlett, Leonard L. Howell, Mar M. SanchezAbstractAdolescence represents a developmental stage in which initiation of drug use typically occurs and is marked by dynamic neurobiological changes. These changes present a sensitive window during which perturbations to normative development lead to alterations in brain circuits critical for stress and emotional regulation as well as reward processing, potentially resulting in an increased susceptibility to psychopathologies. The occurrence ...
Source: Neurobiology of Stress - October 4, 2018 Category: Neuroscience Source Type: research
Multimodal canonical correlation reveals converging neural circuitry across trauma-related disorders of affect and cognition
Publication date: Available online 24 September 2018Source: Neurobiology of StressAuthor(s): Daniel M. Stout, Monte S. Buchsbaum, Andrea D. Spadoni, Victoria B. Risbrough, Irina A. Strigo, Scott C. Matthews, Alan N. SimmonsAbstractTrauma-related disorders of affect and cognition (TRACs) are associated with a high degree of diagnostic comorbidity, which may suggest that these disorders share a set of underlying neural mechanisms. TRACs are characterized by aberrations in functional and structural circuits subserving verbal memory and affective anticipation. Yet, it remains unknown how the neural circuitry underlying these m...
Source: Neurobiology of Stress - October 4, 2018 Category: Neuroscience Source Type: research
Shared gray matter reductions across alcohol use disorder and posttraumatic stress disorder in the anterior cingulate cortex: A dual meta-analysis
Publication date: Available online 27 September 2018Source: Neurobiology of StressAuthor(s): Ruth Klaming, Katia M. Harlé, M. Alejandra Infante, Jessica Bomyea, Charles Kim, Andrea D. SpadoniAbstractThe considerable comorbidity of posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD) poses a greater public health burden than either condition alone. Although there is a substantial body of evidence linking the direct neurotoxic effect of heavy drinking to gray matter (GM) deficits, as well as a growing body of literature supporting a strong association between PTSD and GM alterations, there is scant research ...
Source: Neurobiology of Stress - October 4, 2018 Category: Neuroscience Source Type: research
The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours
Publication date: November 2018Source: Neurobiology of Stress, Volume 9Author(s): Ryan J. Keenan, Jacky Chan, Paul S. Donnelly, Kevin J. Barnham, Laura H. JacobsonAbstractDepression is a highly prevalent psychiatric disorder, yet its etiology is not well understood. The validation of animal models is therefore a critical step towards advancing knowledge about the neurobiology of depression. Psychosocial stress has been promoted as a prospective animal model of depression, however, different protocols exist with variable responses, and further investigations are therefore required. We aimed to characterise the behavioural a...
Source: Neurobiology of Stress - October 4, 2018 Category: Neuroscience Source Type: research
On the safety of repeated ketamine infusions for the treatment of depression: Effects of sex and developmental periods
Publication date: Available online 21 September 2018Source: Neurobiology of StressAuthor(s): C.E. Strong, Mohamed KabbajAbstractIn this review, we will discuss the safety of repeated treatments with ketamine for patients with treatment-resistant depression (TRD), a condition in which patients with major depression do not show any clinical improvements following treatments with at least two antidepressant drugs. We will discuss the effects of these treatments in both sexes at different developmental periods. Numerous small clinical studies have shown that a single, low-dose ketamine infusion can rapidly alleviate depressive...
Source: Neurobiology of Stress - September 21, 2018 Category: Neuroscience Source Type: research
Social defeat stress and escalation of cocaine and alcohol consumption: Focus on CRF
Publication date: Available online 19 September 2018Source: Neurobiology of StressAuthor(s): Emily L. Newman, Michael Z. Leonard, Danielle T. Arena, Rosa M.M. de Almeida, Klaus A. MiczekAbstractBoth the ostensibly aversive effects of unpredictable episodes of social stress and the intensely rewarding effects of drugs of abuse activate the mesocorticolimbic dopamine systems. Significant neuroadaptations in interacting stress and reward neurocircuitry may underlie the striking connection between stress and substance use disorders. In rodent models, recurring intermittent exposure to social defeat stress appears to produce a ...
Source: Neurobiology of Stress - September 20, 2018 Category: Neuroscience Source Type: research
Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse
Publication date: Available online 17 September 2018Source: Neurobiology of StressAuthor(s): Sarah R. Horn, Leslie E. Roos, Elliot T. Berkman, Philip A. FisherAbstractEarly life adversity is a documented risk factor for substance abuse and addiction. The pre- and perinatal period (i.e., from implantation, through pregnancy, to 6 months of age) is a critical period marked by high biological plasticity and vulnerability, making perinatal stress a particularly robust form of adversity. The neuroendocrine and immune systems are key mechanisms implicated in the transmission of addiction risk. We review animal and human studies ...
Source: Neurobiology of Stress - September 18, 2018 Category: Neuroscience Source Type: research
Stress reactivity and the developmental psychopathology of adolescent substance use
Publication date: Available online 12 September 2018Source: Neurobiology of StressAuthor(s): Tara M. Chaplin, Claire Niehaus, Stefanie F. GonçalvesAbstractAdolescence represents a period of risk for initiation of substance use and the development of substance use disorders (SUDs). In addition, during adolescence, there is rapid development of stress reactivity systems. This paper describes a conceptual model of the role of stress reactivity in the development of substance use in adolescence. It is proposed that some children develop maladaptive patterns of emotional, physiological, and neural reactivity to stressful situa...
Source: Neurobiology of Stress - September 13, 2018 Category: Neuroscience Source Type: research
