The effects of acute stress on the calibration of persistence
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Karolina M. Lempert, Joseph T. McGuire, Danielle B. Hazeltine, Elizabeth A. Phelps, Joseph W. KableAbstractPeople frequently fail to wait for delayed rewards after choosing them. These preference reversals are sometimes thought to reflect self-control failure. Other times, however, continuing to wait for a delayed reward may be counterproductive (e.g., when reward timing uncertainty is high). Research has demonstrated that people can calibrate how long to wait for rewards in a given environment. Thus, the role of self-control might be to inte...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Differential impact of Met receptor gene interaction with early-life stress on neuronal morphology and behavior in mice
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Hanke Heun-Johnson, Pat LevittAbstractEarly adversity in childhood increases the risk of anxiety, mood, and post-traumatic stress disorders in adulthood, and specific gene-by-environment interactions may increase risk further. A common functional variant in the promoter region of the gene encoding the human MET receptor tyrosine kinase (rs1858830 ‘C’ allele) reduces expression of MET and is associated with altered cortical circuit function and structural connectivity. Mice with reduced Met expression exhibit changes in anxiety-like and co...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Maternal separation stress leads to resilience against neuropathic pain in adulthood
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Julien Genty, Milène Tetsi Nomigni, Fernand Anton, Ulrike HaneschAbstractEarly life stress (ELS) leads to a permanent reprogramming of biochemical stress response cascades that may also be relevant for the processing of chronic pain states such as neuropathy. Despite clinical evidence, little is known about ELS-related vulnerability for neuropathic pain and the possibly underlying etiology.In the framework of experimental studies aimed at investigating the respective relationships we used the established ELS model of maternal separation (MS)...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Sex differences after chronic stress in the expression of opioid-, stress- and neuroplasticity-related genes in the rat hippocampus
In conclusion, modest sex- and regional-differences are seen in expression of the opioid receptor genes, as well as genes involved in stress and plasticity responses in the hippocampus following CIS. (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Giorgio Bergamini, Jonas Mechtersheimer, Damiano Azzinnari, Hannes Sigrist, Michaela Buerge, Robert Dallmann, Robert Freije, Afroditi Kouraki, Jolanta Opacka-Juffry, Erich Seifritz, Boris Ferger, Tobias Suter, Christopher R. PryceAbstractPsychosocial stress is a major risk factor for depression, stress leads to peripheral and central immune activation, immune activation is associated with blunted dopamine (DA) neural function, DA function underlies reward interest, and reduced reward interest is a core symptom of depression. These states migh...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Jessica L. Bolton, Christina M. Ruiz, Neggy Rismanchi, Gissell A. Sanchez, Erik Castillo, Jeff Huang, Christopher Cross, Tallie Z. Baram, Stephen V. MahlerAbstractEarly-life adversity increases the risk for emotional disorders such as depression and schizophrenia. Anhedonia, thought to be a core feature of these disorders, is provoked by our naturalistic rodent model of childhood adversity (i.e., rearing pups for one week in cages with limited bedding and nesting, LBN). Drug use and addiction are highly comorbid with psychiatric disorders fea...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
The relationship between stress and Alzheimer's disease
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Nicholas J. JusticeAbstractStress is critically involved in the development and progression of disease. From the stress of undergoing treatments to facing your own mortality, the physiological processes that stress drives have a serious detrimental effect on the ability to heal, cope and maintain a positive quality of life. This is becoming increasingly clear in the case of neurodegenerative diseases. Neurodegenerative diseases involve the devastating loss of cognitive and motor function which is stressful in itself, but can also disrupt neur...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Distinct CCL2, CCL5, CCL11, CCL27, IL-17, IL-6, BDNF serum profiles correlate to different job-stress outcomes
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Alessio Polacchini, Damiano Girardi, Alessandra Falco, Nunzia Zanotta, Manola Comar, Nicola Alberto De Carlo, Enrico TongiorgiAbstractChronic psychosocial stress at workplace is an important factor in the development of physical and mental illness. Objective biological measures of chronic stress are still lacking, but inflammatory response and growth factors are increasingly considered as potential stress biomarkers. Therefore, we investigated the relationship between psychophysical strain and serum levels of 48 chemokines, cytokines and grow...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Lianne Hoeijmakers, Sylvie L. Lesuis, Harm Krugers, Paul J. Lucassen, Aniko KorosiAbstractStress experienced early in life (ES), in the form of childhood maltreatment, maternal neglect or trauma, enhances the risk for cognitive decline in later life. Several epidemiological studies have now shown that environmental and adult life style factors influence AD incidence or age-of-onset and early-life environmental conditions have attracted attention in this respect. There is now emerging interest in understanding whether ES impacts the risk to de...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Evidence for altered brain reactivity to norepinephrine in Veterans with a history of traumatic stress
ConclusionsThese results are consistent with increased central nervous system responsiveness to noradrenergic signaling in individuals with a history of traumatic exposure, raising the possibility that there may be long-lasting physiologic effects of trauma-exposure that exist independently of whether an individual meets criteria for PTSD at any given point in time. Exploration of the mechanism by which brain responsiveness to NE is modulated following trauma holds the possibility of finding new strategies for both preventing and treating PTSD. (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Accelerated DNA methylation aging and increased resilience in veterans: The biological cost for soldiering on
This study investigates the relationship between epigenetic aging and risk and protective factors of PTSD. Genome-wide DNA methylation analysis was performed in 211 individuals including combat-exposed Australian veterans (discovery cohort, n = 96 males) and trauma-exposed civilian males from the Grady Trauma Project (replication cohort, n = 115 males). Primary measures included the Clinician Administered PTSD Scale for DSM-5 and the Connor-Davidson Resilience Scale (CD-RISC). DNAm age prediction was performed using the validated epigenetic clock calculator. Veterans with PTSD had increased PTSD symptom severity (P...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Functional connectivity of resting-state, working memory and inhibition networks in perceived stress
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Jo A. Archer, Annie Lee, Anqi Qiu, Shen-Hsing Annabel ChenAbstractExperimental imaging studies on the effects of acute stress have revealed functional changes in the amygdalae, hippocampi and medial frontal cortices. However, much less is known about the association between perceived stress and neurological function which may have implications for the development of stress related disorders. Participants completed a working-memory task and an inhibition task whilst undergoing a functional magnetic resonance imaging (fMRI) scan. Task related a...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Reduced left ventricular dimension and function following early life stress: A thrifty phenotype hypothesis engendering risk for mood and anxiety disorders
ConclusionsELS is associated with both structural and functional reductions of left ventricular measures, potentially implying a body-wide thrifty phenotype. Parallel “thrift” adaptations may occur in key brain areas following ELS and may play an unexplored role in mood and anxiety disorder susceptibility. (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Influencing connectivity and cross-frequency coupling by real-time source localized neurofeedback of the posterior cingulate cortex reduces tinnitus related distress
ConclusionThis suggests that neurofeedback could remove the information, processed in beta and gamma, from the carrier wave, alpha, which transports the high frequency information and influences the salience attributed to the tinnitus sound. Based on the observation that much pathology is the result of an abnormal functional connectivity within and between neural networks various pathologies should be considered eligible candidates for the application of source localized EEG based neurofeedback training.Graphical abstract (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Sex differences in chronic stress responses and Alzheimer's disease
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Yan Yan, Sky Dominguez, Daniel W. Fisher, Hongxin DongAbstractClinical studies indicate that Alzheimer's disease (AD) disproportionately affects women in both disease prevalence and severity, but the mechanisms underlying this sex divergence are unknown. Though some have suggested this difference in risk is a reflection of known differences in longevity between men and women, mounting clinical and preclinical evidence supports women also having intrinsic susceptibilities towards the disease. While a number of potential risk factors have been ...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
