Editorial
Publication date: Available online 8 July 2019Source: Neurobiology of StressAuthor(s): Rita Valentino (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 11, 2019 Category: Neuroscience Source Type: research
Buprenorphine prevents stress-induced blunting of nucleus accumbens dopamine response and approach behavior to food reward in mice
Publication date: Available online 12 June 2019Source: Neurobiology of StressAuthor(s): Shivon Robinson, Tiffany E. Hill-Smith, Irwin LuckiAbstractAlterations to the mesolimbic dopamine (DA) system are thought to underlie dysfunctional reward processing in stress-related psychiatric disorders. Using in vivio microdialysis in awake freely moving mice, we assessed the effects of stress on the motivational and neurochemical correlates underlying conditioned approach behavior for palatable food in the non-deprived mouse. Mice trained to approach and consume food in a familiar environment exhibited a 30% increase in nucleus acc...
Source: Neurobiology of Stress - June 14, 2019 Category: Neuroscience Source Type: research
Cardiovascular outcomes related to social defeat stress: New insights from resilient and susceptible rats
Publication date: Available online 6 June 2019Source: Neurobiology of StressAuthor(s): Gessynger Morais-Silva, Willian Costa-Ferreira, Lucas Gomes-de-Souza, Jacqueline C. Pavan, Carlos C. Crestani, Marcelo T. MarinAbstractStress exposure is an important risk factor for psychiatric and cardiovascular disorders. Two phenotypes related to coping with stress can be observed in rodents that experience chronic social defeat stress (SDS): susceptible, showing social avoidance and behavioral changes related to depression, and resilient, showing none of these alterations. Moreover, a strong correlation exists between depression and...
Source: Neurobiology of Stress - June 6, 2019 Category: Neuroscience Source Type: research
HPA axis function and diurnal cortisol in post-traumatic stress disorder: A systematic review
ConclusionDespite some indications of an association between PTSD and dysregulated HPA axis functionality as demonstrated by diurnal cortisol output, the current review has revealed mixed findings. As such, a complete understanding of HPA axis dysregulation as it relates to PTSD remains unestablished. Given the findings, further investigation into the relationship between PTSD trauma-exposed and non-PTSD trauma-exposed individuals and diurnal cortisol is warranted. (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - June 5, 2019 Category: Neuroscience Source Type: research
Editorial for neurobiology of stress special issue on stress and substance abuse throughout development
Publication date: Available online 3 June 2019Source: Neurobiology of StressAuthor(s): Rita J. Valentino (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - June 4, 2019 Category: Neuroscience Source Type: research
Chronic unpredictable stress influenced the behavioral but not the neurodegenerative impact of paraquat
Publication date: Available online 31 May 2019Source: Neurobiology of StressAuthor(s): Chris Rudyk, Zach Dwyer, Jessica McNeill, Natalina Salmaso, Kyle Farmer, Natalie Prowse, Shawn HayleyAbstractThe impact of psychological stressors on the progression of motor and non-motor disturbances observed in Parkinson's disease (PD) has received little attention. Given that PD likely results from many different environmental “hits”, we were interested in whether a chronic unpredictable stressor regimen would act additively or possibly even synergistically to augment the impact of the toxicant, paraquat, which has previously bee...
Source: Neurobiology of Stress - June 2, 2019 Category: Neuroscience Source Type: research
Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system
Publication date: Available online 25 May 2019Source: Neurobiology of StressAuthor(s): Ryan R. Wyrofsky, Beverly A.S. Reyes, Xiao-Yan Zhang, Seema Bhatnagar, Lynn G. Kirby, Elisabeth J. Van BockstaeleAbstractThe endocannabinoid (eCB) system has been implicated in a variety of physiological functions due to abundant expression of its receptors and endogenous ligands in the central nervous system. Substantial progress has been made in understanding how the eCB system influences the brain norepinephrine (NE) system, an important neurochemical target in the continued development of new therapies for stress-induced psychiatric ...
Source: Neurobiology of Stress - May 26, 2019 Category: Neuroscience Source Type: research
Sex differences in neural stress responses and correlation with subjective stress and stress regulation
Publication date: Available online 25 May 2019Source: Neurobiology of StressAuthor(s): Elizabeth V. Goldfarb, Dongju Seo, Rajita SinhaAbstractEmotional stress responses, encompassing both stress reactivity and regulation, have been shown to differ between men and women, but the neural networks supporting these processes remain unclear. The current study used functional neuroimaging (fMRI) to investigate sex differences in neural responses during stress and the sex-specific relationships between these responses and emotional stress responses for men and women. A significant sex by condition interaction revealed that men sho...
Source: Neurobiology of Stress - May 25, 2019 Category: Neuroscience Source Type: research
Publisher's Note
Publication date: February 2019Source: Neurobiology of Stress, Volume 10Author(s): (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - May 23, 2019 Category: Neuroscience Source Type: research
Early life exposures, neurodevelopmental disorders, and transposable elements
Publication date: Available online 21 May 2019Source: Neurobiology of StressAuthor(s): Hannah E. Lapp, Richard G. HunterAbstractTransposable elements make up a much larger portion of the genome than protein-coding genes, yet we know relatively little about their function in the human genome. However, we are beginning to more fully understand their role in brain development, neuroinflammation, and adaptation to environmental insults such as stress. For instance, glucocorticoid receptor activation regulates transposable elements in the brain following acute stress. Early life is a period of substantial brain development duri...
Source: Neurobiology of Stress - May 23, 2019 Category: Neuroscience Source Type: research
Publisher’s Note
Publication date: Available online 15 May 2019Source: Neurobiology of StressAuthor(s): Rachael Engels (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - May 16, 2019 Category: Neuroscience Source Type: research
Parenting stress: A novel mechanism of addiction vulnerability
Publication date: Available online 15 May 2019Source: Neurobiology of StressAuthor(s): Helena JV. Rutherford, Linda C. MayesAbstractAddiction remains a significant public health concern. Despite numerous public health initiatives, many parents continue to use substances during the prenatal and postpartum period. While stress has been implicated in the maintenance of substance use disorders more generally, we propose that parenting stress specifically increases vulnerability to substance use in adults caring for young children. To explore this notion, we first consider the neurobiology of the adult transition to parenthood ...
Source: Neurobiology of Stress - May 16, 2019 Category: Neuroscience Source Type: research
Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF/TRKB signaling
In this study, our objective was to examine the effect of branched-chain amino acids (BCAA), commonly used by athletes, on susceptibility to stress. Male C57BL/6 mice were subjected to daily defeat sessions by a CD1 aggressor, for 10 days. On day11, the behavior of mice was assessed using the social interaction test, elevated plus maze and open field. Mice received the BCAA leucine, isoleucine or valine before each defeat session. Furthermore, we examined whether BCAA regulate brain derived neurotrophic factor (BDNF) signaling by using a brain-permeable tropomyosin receptor kinase B (TRKB) inhibitor, ANA-12. We also tested...
Source: Neurobiology of Stress - May 15, 2019 Category: Neuroscience Source Type: research
Stress and glucocorticoid modulation of feeding and metabolism
Publication date: Available online 15 May 2019Source: Neurobiology of StressAuthor(s): G. Balsevich, A. Abizaid, A. Chen, I.N. Karatsoreos, M.V. SchmidtAbstractThis perspective highlights research presented as part of the symposium entitled, “Stress and Glucocorticoid Modulation of Feeding and Metabolism” at the 2018 Neurobiology of Stress Workshop held in Banff, AB, Canada. The symposium comprised five researchers at different career stages who each study different aspects of the interaction between the stress response and metabolic control. Their collective results reveal the complexity of this relationship in terms ...
Source: Neurobiology of Stress - May 15, 2019 Category: Neuroscience Source Type: research
Interventions after acute stress prevent its delayed effects on the amygdala
Publication date: Available online 30 April 2019Source: Neurobiology of StressAuthor(s): Prabahan Chakraborty, Sumantra ChattarjiAbstractStress is known to elicit contrasting patterns of plasticity in the amygdala and hippocampus. While chronic stress leads to neuronal atrophy in the rodent hippocampus, it has the opposite effect in the basolateral amygdala (BLA). Further, even a single episode of acute stress is known to elicit delayed effects in the amygdala. For example, 2 h of immobilisation stress has been shown to cause a delayed increase in dendritic spine density on BLA principal neurons 10 days later in young ra...
Source: Neurobiology of Stress - May 1, 2019 Category: Neuroscience Source Type: research
