Allopregnanolone: From molecular pathophysiology to therapeutics. A brief historical perspective
Publication date: Available online 14 March 2020Source: Neurobiology of StressAuthor(s): Steven Paul, Graziano Pinna, Alessandro Guidotti (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - March 16, 2020 Category: Neuroscience Source Type: research
Prenatal Resident-Intruder Stress Decreases Levels of Allopregnanolone in the Cortex, Hypothalamus, and Midbrain of Males, and Increases Levels in the Hippocampus and Cerebellum of Female, Juvenile Rat Offspring
Publication date: Available online 3 March 2020Source: Neurobiology of StressAuthor(s): Jennifer K. Torgersen, Rose Petitti, Sedric Tello, Vincenzo F. Lembo, Cheryl A. Frye (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - March 3, 2020 Category: Neuroscience Source Type: research
Allopregnanolone in Premenstrual Dysphoric Disorder (PMDD): Evidence for Dysregulated Sensitivity to GABA-A Receptor Modulating Neuroactive Steroids Across the Menstrual Cycle
Publication date: Available online 4 February 2020Source: Neurobiology of StressAuthor(s): Liisa Hantsoo, C. Neill EppersonAbstractPremenstrual dysphoric disorder (PMDD) is a severe mood disorder with core symptoms (affective lability, irritability, depressed mood, anxiety) and increased sensitivity to stress occurring in the luteal phase of the menstrual cycle. PMDD can be conceptualized as a disorder of suboptimal sensitivity to neuroactive steroid hormones (NASs). In this review, we describe the role of the NAS allopregnanolone (ALLO), a positive allosteric modulator of the GABAA receptor (GABAA-R), in PMDD’s pathophy...
Source: Neurobiology of Stress - February 5, 2020 Category: Neuroscience Source Type: research
Allopregnanolone in Postpartum Depression: Role in Pathophysiology and Treatment
Publication date: Available online 3 February 2020Source: Neurobiology of StressAuthor(s): Samantha Meltzer-Brody, Stephen J. KanesAbstractPostpartum depression (PPD) is a unique subtype of major depressive disorder and a substantial contributor to maternal morbidity and mortality. In addition to affecting the mother, PPD can have short- and long-term consequences for the infant and partner. The precise etiology of PPD is unknown, but proposed mechanisms include altered regulation of stress response pathways, such as the hypothalamic-pituitary-adrenal axis, and dysfunctional gamma-aminobutyric acid (GABA) signaling, and fu...
Source: Neurobiology of Stress - February 4, 2020 Category: Neuroscience Source Type: research
Pregnane Steroidogenesis is Altered by HIV-1 Tat and Morphine: Physiological Allopregnanolone is Protective against Neurotoxic and Psychomotor Effects
Publication date: Available online 29 January 2020Source: Neurobiology of StressAuthor(s): Jason J. Paris, Philippe Liere, Sarah Kim, Fakhri Mahdi, Meagan E. Buchanan, Sara R. Nass, Alaa N. Qrareya, Mohammed F. Salahuddin, Antoine Pianos, Neïké Fernandez, Zia Shariat-Madar, Pamela E. Knapp, Michael Schumacher, Kurt F. HauserAbstractPregnane steroids, particularly allopregnanolone (AlloP), are neuroprotective in response to central insult. While unexplored in vivo, AlloP may confer protection against the neurological dysfunction associated with human immunodeficiency virus type 1 (HIV-1). The HIV-1 regulatory protein, tra...
Source: Neurobiology of Stress - January 29, 2020 Category: Neuroscience Source Type: research
Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor
Publication date: May 2020Source: Neurobiology of Stress, Volume 12Author(s): Delia Belelli, Derk Hogenkamp, Kelvin W. Gee, Jeremy J. LambertAbstractIn the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR). These reports were followed by the discovery that such steroids may be synthesised not only in peripheral endocrine glands, but locally in the central nervous system (CNS), to potentially act as paracrine, or autocrine “neurosteroid” messengers, thereby fine tuning neuronal i...
Source: Neurobiology of Stress - January 18, 2020 Category: Neuroscience Source Type: research
Interactions between pyridostigmine bromide and stress on glutamatergic neurochemistry: insights from a rat model of Gulf War Illness
Publication date: Available online 31 December 2019Source: Neurobiology of StressAuthor(s): V.A. Macht, J.L. Woodruff, H.E. Burzynski, C.A. Grillo, L.P. Reagan, J.R. FadelAbstractPyridostigmine bromide (PB) was administered to soldiers during the first Gulf War as a prophylactic treatment to protect against toxicity in the event of exposure to nerve agents. Although originally thought to pose minimal risk to soldiers, epidemiological studies have since correlated PB administration with the development of a variety of symptoms, including cognitive dysfunction, termed Gulf War Illness (GWI). We previously demonstrated that i...
Source: Neurobiology of Stress - January 1, 2020 Category: Neuroscience Source Type: research
Post-finasteride syndrome: an emerging clinical problem
Publication date: Available online 26 December 2019Source: Neurobiology of StressAuthor(s): Silvia Diviccaro, Roberto Cosimo Melcangi, Silvia GiattiAbstractThe presence of side effects during pharmacological treatment is unfortunately a quite common problem. In this review, we focused our attention on adverse events related to 5 alpha-reductase (5α-R) inhibitors (i.e., finasteride and dutasteride), approved for the treatment of benign prostatic hyperplasia and androgenetic alopecia (AGA).Although these drugs are generally well tolerated, many reports described adverse effects in men during treatment, such as sexual dysfun...
Source: Neurobiology of Stress - December 28, 2019 Category: Neuroscience Source Type: research
Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: implication for drug abuse
Publication date: Available online 27 December 2019Source: Neurobiology of StressAuthor(s): Iris Bartolomé, Anna Llidó, Sònia Darbra, Marc PallarèsAbstractSeveral studies have highlighted the role that early postnatal levels of allopregnanolone play in the development of the CNS and adult behavior. Changes in allopregnanolone levels related to stress have been observed during early postnatal periods, and perinatal stress has been linked to neuropsychiatric disorders. The alteration of early postnatal allopregnanolone levels in the first weeks of life has been proven to affect adult behaviors, such as anxiety-related be...
Source: Neurobiology of Stress - December 28, 2019 Category: Neuroscience Source Type: research
Realizing the therapeutic potential of GABAAR-active neurosteroids.
Publication date: Available online 23 December 2019Source: Neurobiology of StressAuthor(s): Delia Belelli, Derk Hogenkamp, Kelvin W. Gee, Jeremy J. LambertAbstractIn the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR). These reports were followed by the discovery that such steroids may be synthesised not only in peripheral endocrine glands, but locally in the central nervous system (CNS), to potentially act as paracrine, or autocrine “neurosteroid” messengers, thereby fine tun...
Source: Neurobiology of Stress - December 25, 2019 Category: Neuroscience Source Type: research
GABA-A receptor modulating steroids in acute and chronic stress; relevance for cognition and dementia?
Publication date: Available online 20 December 2019Source: Neurobiology of StressAuthor(s): S.K.S. Bengtsson, T. Bäckström, R. Brinton, R.W. Irwin, M. Johansson, J. Sjöstedt, M.D. WangAbstractCognitive dysfunction, dementia and Alzheimer’s disease (AD) are increasing as the population worldwide ages. Therapeutics for these conditions is an unmet need. This review focuses on the role of the positive GABA-A receptor modulating steroid allopregnanolone (APα), it’s role in underlying mechanisms for impaired cognition and of AD, and to determine options for therapy of AD. On one hand, APα given intermittently promotes ...
Source: Neurobiology of Stress - December 22, 2019 Category: Neuroscience Source Type: research
Involvement Of Oxidative Stress And Mitochondrial Mechanisms In Air Pollution-Related Neurobiological Impairments
ConclusionThis study demonstrates a causal mechanism mediating SVEE-induced behavioral deficits in rats. We further established that SVEE is a toxicological stressor that induces oxidative stress and results in mitochondrial impairment, which by disrupting neural circuitry impairs cognitive and behavioral functions.Graphical abstract (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - December 19, 2019 Category: Neuroscience Source Type: research
Acute Sleep Deprivation During Pregnancy in Rats: Rapid Elevation of Placental and Fetal Inflammation and Kynurenic Acid
Publication date: Available online 14 December 2019Source: Neurobiology of StressAuthor(s): Annalisa M. Baratta, Nickole R. Kanyuch, Casey A. Cole, Homayoun Valafar, Jessica Deslauriers, Ana PocivavsekAbstractThe kynurenine pathway (KP) is the dominant pathway for tryptophan degradation in the mammalian body and emerging evidence suggests that acute episodes of sleep deprivation (SD) disrupt tryptophan metabolism via the KP. Increases in the neuroactive KP metabolite kynurenic acid (KYNA) during pregnancy may lead to a higher risk for disrupted neurodevelopment in the offspring. As pregnancy is a critical period during whi...
Source: Neurobiology of Stress - December 16, 2019 Category: Neuroscience Source Type: research
Pleiotropic Actions of Allopregnanolone Underlie Therapeutic Benefits in Stress-Related Disease
Publication date: Available online 27 November 2019Source: Neurobiology of StressAuthor(s): Giorgia Boero, Patrizia Porcu, A. Leslie MorrowAbstractFor several years, research from around the world has suggested that the neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (allopregnanolone) may have therapeutic potential for treatment of various stress-related diseases including post-traumatic stress disorder (PTSD), depression, alcohol use disorders (AUDs), as well as neurological and psychiatric conditions that are worsened in the presence of stress, such as multiple sclerosis, schizophrenia and seizure disorders. In th...
Source: Neurobiology of Stress - November 28, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: November 2019Source: Neurobiology of Stress, Volume 11Author(s): (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - November 23, 2019 Category: Neuroscience Source Type: research
