Effects of restraint stress on the regulation of hippocampal glutamate receptor and inflammation genes in female C57BL/6 and BALB/c mice
We examined the stress induced changes in the regulation of 11 inflammatory cytokine genes and 12 glutamate receptor genes in the hippocampus of female BALB/c and C57BL/6 mice using quantitative PCR. Elevated proinflammatory cytokine genes include Tumor Necrosis Factor alpha (TNFa), nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB), Interleukin 1 alpha (IL1a), Interleukin 1 receptor (IL1R), Interleukin 10 receptor alpha subunit (IL10Ra), Interleukin 10 receptor beta subunit (IL10Rb), and tumor necrosis factor (TNF) super family members. Our results show that BALB/c and C57BL/6 mice differ in the genes i...
Source: Neurobiology of Stress - May 1, 2019 Category: Neuroscience Source Type: research
Editorial: Stress and its impact on Alzheimer's Disease
Publication date: Available online 23 April 2019Source: Neurobiology of StressAuthor(s): Hongxin Dong, John G. Csernansky (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - April 24, 2019 Category: Neuroscience Source Type: research
In the face of stress: Interpreting individual differences in stress-induced facial expressions
Publication date: Available online 20 April 2019Source: Neurobiology of StressAuthor(s): Leah M. Mayo, Markus HeiligAbstractStress is an inevitable part of life that can profoundly impact social and emotional functioning, contributing to the development of psychiatric disease. One key component of emotion and social processing is facial expressions, which humans can readily detect and react to even without conscious awareness. Facial expressions have been the focus of philosophic and scientific interest for centuries. Historically, facial expressions have been relegated to peripheral indices of fixed emotion states. More r...
Source: Neurobiology of Stress - April 21, 2019 Category: Neuroscience Source Type: research
Age- and sex-dependent impact of repeated social stress on morphology of rat prefrontal cortex pyramidal neurons
In this study, male and female adolescent (42–48 days old, 4 rats per group) or adult (68–72 days old, 4 rats per group) Sprague-Dawley rats were exposed to 5 days of repeated social stress in the resident-intruder paradigm or control manipulation. We examined dendritic morphology of cells in the mPFC in both layer II/III and Layer V. Repeated social stress resulted in decreased dendritic branching in layer II/III apical dendrites regardless of sex or age. In apical layer V dendrites, stress increased branching in adult males but decreased it in all other groups. Stress resulted in a decrease in dendritic spines in lay...
Source: Neurobiology of Stress - April 13, 2019 Category: Neuroscience Source Type: research
Noradrenergic depletion causes sex specific alterations in the endocannabinoid system in the Murine prefrontal cortex
Publication date: Available online 10 April 2019Source: Neurobiology of StressAuthor(s): M.A. Urquhart, J.A. Ross, B.A.S. Reyes, M. Nitikman, S.A. Thomas, K. Mackie, E.J. Van BockstaeleAbstractBrain endocannabinoids (eCB), acting primarily via the cannabinoid type 1 receptor (CB1r), are involved in the regulation of many physiological processes, including behavioral responses to stress. A significant neural target of eCB action is the stress-responsive norepinephrine (NE) system, whose dysregulation is implicated in myriad psychiatric and neurodegenerative disorders. Using Western blot analysis, the protein expression leve...
Source: Neurobiology of Stress - April 11, 2019 Category: Neuroscience Source Type: research
Persistent pain intensifies recall of consolidated fear memories
In conclusion, this study provides evidence that persistent pain has a significant impact on consolidated fear memories. Very likely the underlying mechanism for this phenomenon is increased inhibitory input onto the BLA to mPFC projection neurons, possibly from neurons with induced parvalbumin expression. Conceivably, the increased fear response to consolidated fear memory is a harbinger for the later development of anxiety and depression symptoms associated with chronic pain. (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - April 11, 2019 Category: Neuroscience Source Type: research
The mediating role of hippocampal networks on stress regulation in amnestic mild cognitive impairment
ConclusionsExtra hippocampal networks may be recruited as compensation to attend the maintenance of relatively normal stress regulation in aMCI by alleviating the detrimental effects of chronic stress exposure on acute stress regulation. (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - April 9, 2019 Category: Neuroscience Source Type: research
Sustained corticosterone rise in the prefrontal cortex is a key factor for chronic stress-induced working memory deficits in mice
Publication date: Available online 4 April 2019Source: Neurobiology of StressAuthor(s): Dominguez Gaelle, Henkous Nadia, Prevot Thomas, David Vincent, Guillou Jean-Louis, Belzung Catherine, Mons Nicole, Béracochéa DanielAbstractExposure to prolonged, unpredictable stress leads to glucocorticoids-mediated long-lasting neuroendocrine abnormalities associated with emotional and cognitive impairments. Excessive levels of serum glucocorticoids (cortisol in humans, corticosterone in rodents) contribute notably to deficits in working memory (WM), a task which heavily relies on functional interactions between the medial prefront...
Source: Neurobiology of Stress - April 5, 2019 Category: Neuroscience Source Type: research
Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine
Publication date: Available online 2 April 2019Source: Neurobiology of StressAuthor(s): Paolo Tornese, Nathalie Sala, Daniela Bonini, Tiziana Bonifacino, Luca La Via, Marco Milanese, Giulia Treccani, Mara Seguini, Alessandro Ieraci, Jessica Mingardi, Jens R. Nyengaard, Stefano Calza, Giambattista Bonanno, Gregers Wegener, Alessandro Barbon, Maurizio Popoli, Laura MusazziAbstractDepression is a debilitating mental disease, characterized by persistent low mood and anhedonia. Stress represents a major environmental risk factor for depression; the complex interaction of stress with genetic factors results in different individu...
Source: Neurobiology of Stress - April 4, 2019 Category: Neuroscience Source Type: research
A model of amygdala function following plastic changes at specific synapses during extinction
Publication date: Available online 1 April 2019Source: Neurobiology of StressAuthor(s): Maxwell R. Bennett, Les Farnell, William G. Gibson, Jim LagopoulosAbstractThe synaptic networks in the amygdala have been the subject of intense interest in recent times, primarily because of the role of this structure in emotion. Fear and its extinction depend on the workings of these networks, with particular interest in extinction because of its potential to ameliorate adverse symptoms associated with post-traumatic stress disorder. Here we place emphasis on the extinction networks revealed by recent techniques, and on the probable p...
Source: Neurobiology of Stress - April 2, 2019 Category: Neuroscience Source Type: research
Cell signaling dependence of rapid glucocorticoid-induced endocannabinoid synthesis in hypothalamic neuroendocrine cells
Publication date: Available online 21 March 2019Source: Neurobiology of StressAuthor(s): Christina Harris, Grant L. Weiss, Shi Di, Jeffrey G. TaskerAbstractGlucocorticoids induce a rapid synthesis of endocannabinoid in hypothalamic neuroendocrine cells by activation of a putative membrane receptor. Somato-dendritically released endocannabinoid acts as a retrograde messenger to suppress excitatory synaptic inputs to corticotropin-releasing hormone-, oxytocin-, and vasopressin-secreting cells. The non-genomic signaling mechanism responsible for rapid endocannabinoid synthesis by glucocorticoids has yet to be fully characteri...
Source: Neurobiology of Stress - March 23, 2019 Category: Neuroscience Source Type: research
Stress exposures, neurodevelopment and health measures in the ABCD study
Publication date: Available online 19 March 2019Source: Neurobiology of StressAuthor(s): Elizabeth A. Hoffman, Duncan B. Clark, Natalia Orendain, James Hudziak, Lindsay M. Squeglia, Gayathri J. DowlingAbstractThe Adolescent Brain Cognitive Development (ABCD) Study, a large, longitudinal study of brain development and child health, is uniquely positioned to explore relationships among stress, neurodevelopment, and psychiatric symptomatology, including substance use and addiction. There is much we do not know about how adverse experiences affect the developing brain and cognitive, social, emotional, and academic outcomes. Th...
Source: Neurobiology of Stress - March 20, 2019 Category: Neuroscience Source Type: research
Early life opioid exposure and potential long-term effects
Publication date: Available online 13 March 2019Source: Neurobiology of StressAuthor(s): Hannah Harder, Anne Z. MurphyAbstractThe long-term consequences of perinatal opioid exposure and subsequent development of neonatal opioid withdrawal syndrome is largely unknown and likely dependent on a multitude of factors, including co-morbid drug use, pre- and post-natal care, and individual factors including the maternal-infant relationship and home environment. This review summarizes the current literature from clinical and preclinical studies on perinatal opioid exposure, focusing on the consequences in the offspring. Although a...
Source: Neurobiology of Stress - March 14, 2019 Category: Neuroscience Source Type: research
Chronic unpredictable stress promotes cell-specific plasticity in prefrontal cortex D1 and D2 pyramidal neurons
Publication date: Available online 8 March 2019Source: Neurobiology of StressAuthor(s): E.M. Anderson, D. Gomez, A. Caccamise, D. McPhail, M. HearingAbstractExposure to unpredictable environmental stress is widely recognized as a major determinant for risk and severity in neuropsychiatric disorders such as major depressive disorder, anxiety, schizophrenia, and PTSD. The ability of ostensibly unrelated disorders to give rise to seemingly similar psychiatric phenotypes highlights a need to identify circuit-level concepts that could unify diverse factors under a common pathophysiology. Although difficult to disentangle a caus...
Source: Neurobiology of Stress - March 10, 2019 Category: Neuroscience Source Type: research
Stress: Influence of sex, reproductive status and gender
Publication date: Available online 9 March 2019Source: Neurobiology of StressAuthor(s): Millie Rincón-Cortés, James P. Herman, Sonia Lupien, Jamie Maguire, Rebecca M. ShanskyAbstractEmerging evidence from the preclinical and human research suggests sex differences in responss to different types of stress exposure, and that developmental timing, reproductive status, and biological sex are important factors influencing the degree of HPA activation/function. Here we review data regarding: i) sex differences in behavioral and neural responses to uncontrollable and controllable stressors; ii) distinct trajectories of behavior...
Source: Neurobiology of Stress - March 10, 2019 Category: Neuroscience Source Type: research
