Ovarian status dictates the neuroinflammatory and behavioral consequences of sub-chronic stress exposure in middle-aged female mice
Publication date: Available online 20 November 2019Source: Neurobiology of StressAuthor(s): Rand S. Eid, Stephanie E. Lieblich, Sarah J. Wong, Liisa A.M. GaleaAbstractOvarian hormones influence the outcomes of stress exposure and are implicated in stress-related disorders including depression, yet their roles are often complex and seemingly contradictory. Importantly, depression and stress exposure are associated with immune dysregulation, and ovarian hormones have immunomodulatory properties. However, how ovarian hormones can influence the inflammatory outcomes of stress exposure is poorly understood. Here, we examined th...
Source: Neurobiology of Stress - November 20, 2019 Category: Neuroscience Source Type: research
Allopregnanolone-based treatments for postpartum depression: Why/how do they work?
Publication date: Available online 24 October 2019Source: Neurobiology of StressAuthor(s): Najah Walton, Jamie MaguireAbstractRecent FDA approval of an allopregnanolone-based treatment specifically for postpartum depression, brexanolone, now commercially called Zulresso®, is an exciting development for patients and families impacted by postpartum depression and allows us to start asking questions about why and how this compound is so effective. Allopregnanolone is a neuroactive steroid, or neurosteroid, which can be synthesized from steroid hormone precursors, such as progesterone, or synthesized de novo from cholesterol....
Source: Neurobiology of Stress - October 25, 2019 Category: Neuroscience Source Type: research
Mu opioid receptor regulation of glutamate efflux in the central amygdala in response to predator odor
Publication date: Available online 14 October 2019Source: Neurobiology of StressAuthor(s): Jeffrey Parrilla Carrero, Kris F. Kaigler, George H. Hartshorn, Jim R. Fadel, Marlene A. WilsonAbstractThe amygdala plays an important role in the responses to predator threat. Glutamatergic processes in amygdala regulate the behavioral responses to predator stress, and we have found that exposure to ferret odor activates glutamatergic neurons of the basolateral amygdala [BLA] which are known to project to the central amygdala [CeA]. Therefore, we tested if predator stress would increase glutamate release in the rat CeA using in vivo...
Source: Neurobiology of Stress - October 15, 2019 Category: Neuroscience Source Type: research
Neurosteroids as Novel Antidepressants and Anxiolytics: GABA-A Receptors and Beyond
Publication date: Available online 27 September 2019Source: Neurobiology of StressAuthor(s): Charles F. Zorumski, Steven M. Paul, Douglas F. Covey, Steven MennerickAbstractThe recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a treatment for women with postpartum depression, and successful trials of a related neuroactive steroid, SGE-217, for men and women with major depressive disorder offer the hope of a new era in treating mood and anxiety disorders based on the potential of neurosteroids as modulators of brain function. This review considers potential mechanisms contributing to antidepressant ...
Source: Neurobiology of Stress - September 29, 2019 Category: Neuroscience Source Type: research
Hippocampal connectivity in the aftermath of acute social stress
In this study, using a within-subject design and Granger causal analysis (GCA), we investigated the alterations of resting state effective connectivity from and to hippocampal subregions after an acute social stressor (the Trier Social Stress Test). Participants were engaged in stress and control conditions spaced approximately one month apart. Our findings showed that stress altered the information flows in the thalamus-hippocampus-insula/midbrain circuit. The changes in this circuit could also predict with high accuracy the stress and control conditions at the subject level. These hippocampus-related brain networks have ...
Source: Neurobiology of Stress - September 17, 2019 Category: Neuroscience Source Type: research
Pharmacological interventions during the process of reconsolidation of aversive memories: a systematic review
Publication date: Available online 21 August 2019Source: Neurobiology of StressAuthor(s): Lívia Maria Bolsoni, Antonio Waldo ZuardiAbstractReconsolidation is the return of a memory to a transient state of lability, following memory consolidation, that can occur when memories are evoked. During the process of reconsolidation, memories may be modified by different means, including the administration of drugs, during a period called the "reconsolidation window”. This process has been widely studied in animals, but human studies are limited and include several methodological pitfalls. Our objective was to conducte a systema...
Source: Neurobiology of Stress - August 22, 2019 Category: Neuroscience Source Type: research
Neurobiological links between stress and anxiety
Publication date: Available online 13 August 2019Source: Neurobiology of StressAuthor(s): Nuria Daviu, Michael R. Bruchas, Bita Moghaddam, Carmen Sandi, Anna BeyelerAbstractStress and anxiety have intertwined behavioral and neural underpinnings. These commonalities are critical for understanding each state, as well as their mutual interactions. Grasping the mechanisms underlying this bidirectional relationship will have major clinical implications for managing a wide range of psychopathologies. After briefly defining key concepts for the study of stress and anxiety in pre-clinical models, we present circuit, as well as cel...
Source: Neurobiology of Stress - August 15, 2019 Category: Neuroscience Source Type: research
Editorial: A brief overview of the 2018 Neurobiology of Stress Workshop
Publication date: Available online 14 August 2019Source: Neurobiology of StressAuthor(s): Matthew N. Hill, Richard Hunter, Lawrence P. Reagan (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - August 15, 2019 Category: Neuroscience Source Type: research
Cyclooxygenase-2 inhibition reduces anxiety-like behavior and normalizes enhanced amygdala glutamatergic transmission following chronic oral corticosterone treatment
Publication date: Available online 10 August 2019Source: Neurobiology of StressAuthor(s): Amanda Morgan, Veronika Kondev, Gaurav Bedse, Rita Baldi, David Marcus, Sachin PatelAbstractChronic stress increases the probability of being diagnosed with anxiety disorders, depression, and chronic illness. Pharmacological interventions that reduce the behavioral and physiological effects of chronic stress in animal models, may represent novel approaches to the treatment of stress-related psychiatric disorders. Here, we examined the effects of cyclooxygenase-2 (COX-2) inhibition on anxiety-like behaviors and amygdala glutamatergic s...
Source: Neurobiology of Stress - August 12, 2019 Category: Neuroscience Source Type: research
CRF Signaling Between Neurons in the Paraventricular Nucleus of the Hypothalamus (PVN) Coordinates Stress Responses.
Publication date: Available online 10 August 2019Source: Neurobiology of StressAuthor(s): Zhiying Jiang, Shivakumar Rajamanickam, Nicholas J. JusticeAbstractThe importance of a precisely coordinated neuroendocrine, autonomic, and behavioral stress response was a primary theme at the Stress Neurobiology Workshop 2018, held in the beautiful setting of Banff Provincial Park in Alberta, Canada. Much of the research featured at this meeting reinforced the importance of appropriately responding to stress in order to avoid various neuropsychiatric pathologies, including Post-Traumatic Stress Disorder (PTSD), depression, and addic...
Source: Neurobiology of Stress - August 12, 2019 Category: Neuroscience Source Type: research
Foreword
Publication date: November 2019Source: Neurobiology of Stress, Volume 11Author(s): Nora D. Volkow, Michelle P. Freund, Gayathri J. Dowling (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 30, 2019 Category: Neuroscience Source Type: research
Neuro-Autonomic Changes Induced by Remote Ischemic Preconditioning (RIPC) in Healthy Young Adults: Implications for Stress
In conclusion, RIPC induces changes in the activity of ANS that are linked to stress resistance. (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 28, 2019 Category: Neuroscience Source Type: research
Role of KCNQ Potassium Channels in Stress-induced Deficit of Working Memory
Publication date: Available online 26 July 2019Source: Neurobiology of StressAuthor(s): Amy F.T. Arnsten, Lu E. Jin, Nao J. Gamo, Brian Ramos, Constantinos D. Paspalas, Yury M. Morozov, Anna Kata, Nigel S. Bamford, Mark F. Yeckel, Leonard K. Kaczmarek, Lynda El-HassarAbstractThe prefrontal cortex (PFC) mediates higher cognition but is impaired by stress exposure when high levels of catecholamines activate calcium-cAMP-protein kinase A (PKA) signaling. The current study examined whether stress and increased cAMP-PKA signaling in rat medial PFC (mPFC) reduce pyramidal cell firing and impair working memory by activating KCNQ ...
Source: Neurobiology of Stress - July 28, 2019 Category: Neuroscience Source Type: research
Altered fibrinolytic system in rat models of depression and patients with first-episode depression
Publication date: Available online 26 July 2019Source: Neurobiology of StressAuthor(s): Wenxiu Han, Ruili Dang, Pengfei Xu, Gongying Li, Xueyuan Zhou, Lei Chen, Yujin Guo, Mengqi Yang, Dan Chen, Pei JiangAbstractTissue plasminogen activator (tPA) is a serine protease involved in cleavage of neurotrophic factors. In addition, tPA and neuroserpin can also directly bind to low density lipoprotein receptor-related protein 1 (LRP1), promoting neurogenesis and neurite outgrowth. Given both the cleavage and non-cleavage actions of the fibrinolytic system are crucial in neurological functions, the present study, for the first time...
Source: Neurobiology of Stress - July 28, 2019 Category: Neuroscience Source Type: research
Risk and Protective Effects of Serotonin and BDNF Genes on Stress-Related Adult Psychiatric Symptoms
Publication date: Available online 26 July 2019Source: Neurobiology of StressAuthor(s): Paul G. Nestor, Keira O’Donovan, Hannah E. Lapp, Victoria Choate Hasler, Sara Boodai, Richard HunterAbstractWe focused on individual risk by examining childhood adversity and current psychiatric symptoms in a sample of 100 college students genotyped for both the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF). Naturally occurring allelic variation in 5-HTTLPR (short/long) and BDNF (valine/ methionine) have been strongly implicated in stress-related psychiatric risk, but the combined effects of these a...
Source: Neurobiology of Stress - July 28, 2019 Category: Neuroscience Source Type: research
