Disaggregating physiological components of cortisol output: A novel approach to cortisol analysis in a clinical sample – A proof-of-principle study
Publication date: Available online 7 March 2019Source: Neurobiology of StressAuthor(s): Veronika B. Dobler, Sharon AS. Neufeld, Paul F. Fletcher, Jesus Perez, Naresh Subramaniam, Christoph Teufel, Ian M. GoodyerAbstractAlthough childhood adversity (CA) increases risk for subsequent mental illnesses, developmental mechanisms underpinning this association remain unclear. The hypothalamic-pituitary-adrenal axis (HPAA) is one candidate system potentially linking CA with psychopathology. However, determining developmental effects of CA on HPAA output and differentiating these from effects of current illness has proven difficult...
Source: Neurobiology of Stress - March 8, 2019 Category: Neuroscience Source Type: research
FAAH genotype, CRFR1 genotype, and cortisol interact to predict anxiety in an aging, rural Hispanic population: A Project FRONTIER study
Publication date: Available online 7 March 2019Source: Neurobiology of StressAuthor(s): Breanna N. Harris, Zachary P. Hohman, Callie M. Campbell, Kaleb S. King, Cody A. Tucker, the Garrison Institute on AgingAbstractThe neurophysiological underpinnings involved in susceptibility to and maintenance of anxiety are not entirely known. However, two stress-responsive systems, the hypothalamic-pituitary-adrenal axis and the endocannabinoid system, may interact in anxiety. Here, we examine the relationship between FAAH genotype, CRFR1 genotype, baseline cortisol, and state anxiety in a rural adult population using data from Proje...
Source: Neurobiology of Stress - March 8, 2019 Category: Neuroscience Source Type: research
Effects of hormonal contraceptive phase and progestin generation on stress-induced cortisol and progesterone release
Publication date: Available online 5 March 2019Source: Neurobiology of StressAuthor(s): Alexandra Ycaza Herrera, Sophia Faude, Shawn E. Nielsen, Mallory Locke, Mara MatherAbstractThe stress response differs between women using hormonal contraception and naturally cycling women. Yet, despite ample evidence showing that the stress response differs across the menstrual cycle in naturally cycling women, limited work has investigated whether the stress response differs across the hormonal contraceptive cycle, during which synthetic hormones are taken most of the month but not all of it. To induce a stress response, women using ...
Source: Neurobiology of Stress - March 5, 2019 Category: Neuroscience Source Type: research
Sex differences in corticotropin releasing factor regulation of medial septum-mediated memory formation
Publication date: Available online 20 February 2019Source: Neurobiology of StressAuthor(s): Kimberly Wiersielis, Attilio Ceretti, Arron Hall, Sydney Famularo, Madeleine Salvatore, Alexandra S. Ellis, Harah Jang, Mathieu E. Wimmer, Debra BangasserAbstractStress can disrupt memory and contribute to cognitive impairments in psychiatric disorders, including schizophrenia and attention deficit hyperactivity disorder. These diseases are more common in men than in women, with men showing greater cognitive impairments. Mnemonic deficits induced by stress are mediated, in part, by corticotropin releasing factor (CRF). However, wher...
Source: Neurobiology of Stress - February 21, 2019 Category: Neuroscience Source Type: research
Sex differences in stress-related alcohol use
Publication date: Available online 8 February 2019Source: Neurobiology of StressAuthor(s): MacKenzie R. Peltier, Terril L. Verplaetse, Yann S. Mineur, Ismene L. Petrakis, Kelly P. Cosgrove, Marina R. Picciotto, Sherry A. McKeeAbstractRates of alcohol use disorder (AUD) have increased in women by 84% over the past ten years relative to a 35% increase in men. This substantive increase in female drinking is alarming given that women experience greater alcohol-related health consequences compared to men. Stress is strongly associated with all phases of alcohol addiction, including drinking initiation, maintenance, and relapse ...
Source: Neurobiology of Stress - February 8, 2019 Category: Neuroscience Source Type: research
Chronic stress produces enduring sex- and region-specific alterations in novel stress-induced c-Fos expression
Publication date: Available online 1 February 2019Source: Neurobiology of StressAuthor(s): Kelly M. Moench, Michaela R. Breach, Cara L. WellmanAbstractProlonged or repeated exposure to stress increases risk for a variety of psychological disorders, many of which are marked by dysfunction of corticolimbic brain regions. Notably, women are more likely than men to be diagnosed with these disorders, especially when onset of symptoms follows stressful life events. Using rodent models, investigators have recently begun to elucidate sex-specific changes in the brain and behavior that occur immediately following chronic stress. Ho...
Source: Neurobiology of Stress - February 2, 2019 Category: Neuroscience Source Type: research
Drug-induced stress responses and addiction risk and relapse
Publication date: Available online 1 February 2019Source: Neurobiology of StressAuthor(s): Stephanie E. Wemm, Rajita SinhaAbstractA number of studies have assessed the effects of psychoactive drugs on stress biology, the neuroadaptations resulting from chronic drug use on stress biology, and their effects on addiction risk and relapse. This review mainly covers human research on the acute effects of different drugs of abuse (i.e., nicotine, cannabis, psychostimulants, alcohol, and opioids) on the hypothalamic-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS) responses. We review the literature on acute pe...
Source: Neurobiology of Stress - February 2, 2019 Category: Neuroscience Source Type: research
Child maltreatment and the development of substance use and disorder
Publication date: Available online 7 January 2019Source: Neurobiology of StressAuthor(s): Dante Cicchetti, Elizabeth D. HandleyAbstractChildren who experience maltreatment are at well-documented risk for the development of problematic substance use and disorder in adolescence and beyond. This review applies a developmental psychopathology framework to discuss the complex multilevel probabilistic pathways from child maltreatment to substance use and substance use disorder (SUD). We begin with an overview of the myriad vulnerabilities associated with child maltreatment, including the development of substance use and SUD. Pro...
Source: Neurobiology of Stress - January 8, 2019 Category: Neuroscience Source Type: research
Stress and substance use among sexual and gender minority individuals across the lifespan
Publication date: Available online 27 December 2018Source: Neurobiology of StressAuthor(s): Mike C. Parent, Andrew Arriaga, Teresa Gobble, Alexandra WilleAbstractSexual and gender minority (SGM) individuals face marked disparities in substance use. The present narrative review explores research on substance use in SGM communities using a minority stress theory lens. We define the SGM population and minority stress, and explore stresses and substance use disparities in adolescence, adulthood, and older age. Though research on this topic is beginning to highlight the relationship between stress and substance use for SGM indi...
Source: Neurobiology of Stress - December 28, 2018 Category: Neuroscience Source Type: research
The cellular basis of fetal endoplasmic reticulum stress and oxidative stress in drug-induced neurodevelopmental deficits
Publication date: Available online 27 December 2018Source: Neurobiology of StressAuthor(s): Shang-Yi A. Tsai, Raphael M. Bendriem, Chun-Ting D. LeeAbstractPrenatal substance exposure is a growing public health concern worldwide. Although the opioid crisis remains one of the most prevalent addiction problems in our society, abuse of cocaine, methamphetamines, and other illicit drugs, particularly amongst pregnant women, are nonetheless significant and widespread. Evidence demonstrates prenatal drug exposure can affect fetal brain development and thus can have long-lasting impact on neurobehavioral and cognitive performance ...
Source: Neurobiology of Stress - December 27, 2018 Category: Neuroscience Source Type: research
Sex-associated differences in excitability within the bed nucleus of the stria terminalis are reflective of cell-type
Publication date: Available online 19 December 2018Source: Neurobiology of StressAuthor(s): Hannah Smithers, John Terry, Jonathan Brown, Andrew RandallAbstractThe bed nucleus of the stria terminalis (BNST) is a sexually dimorphic brain region which plays a key role in stress, anxiety, and anxiety-related disorders. Human females have an increased susceptibility to anxiety-related disorders, however the physiological basis of this is not fully understood. Here we examined the effect of the oestrous cycle and sex on the electrophysiological properties of Type I and Type II cells in the anterolateral area of the BNST (BNSTALG...
Source: Neurobiology of Stress - December 20, 2018 Category: Neuroscience Source Type: research
Examining the effect of Early Life Stress on autonomic and endocrine indicators of individual stress reactivity
Publication date: Available online 17 December 2018Source: Neurobiology of StressAuthor(s): Luisa Bönke, Sabine Aust, Yan Fan, Katharina Wirth, Elissa Khawli, Amie Stevense, Ana Herrera, Andrea Loayza, Malek Bajbouj, Simone GrimmAbstractEarly life stress (ELS) is associated with altered stress reactivity and an increased risk for the development of psychopathological conditions in later life. However, depending on whether autonomic or endocrine measures were used as indicators of stress reactivity, previous studies reported conflicting findings of either increased or decreased stress reactivity after ELS experience. In th...
Source: Neurobiology of Stress - December 17, 2018 Category: Neuroscience Source Type: research
Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition
Publication date: Available online 10 December 2018Source: Neurobiology of StressAuthor(s): S. Papalini, F. Michels, N. Kohn, J. Wegman, S. van Hemert, K. Roelofs, A. Arias-Vasquez, E. AartsAbstractProbiotics are microorganisms that provide health benefits when consumed. In animals, probiotics reverse gut microbiome-related alterations in depression-like symptoms, in cognition, and in hormonal stress response. However, in humans, a causal understanding of the gut-brain link in emotion and cognition is lacking. Additionally, whether the effects of probiotics on neurocognition are visible only in presence of stress, remains ...
Source: Neurobiology of Stress - December 11, 2018 Category: Neuroscience Source Type: research
Stress, sensitive periods, and substance abuse
Publication date: Available online 27 November 2018Source: Neurobiology of StressAuthor(s): Susan L. AndersenAbstractResearch on the inter-relationship between drug abuse and social stress has primarily focused on the role of stress exposure during adulthood and more recently, adolescence. Adolescence is a time of heightened reward sensitivity, but it is also a time when earlier life experiences are expressed. Exposure to stress early in postnatal life is associated with an accelerated age of onset for drug use. Lifelong addiction is significantly greater if drug use is initiated during early adolescence. Understanding how...
Source: Neurobiology of Stress - November 28, 2018 Category: Neuroscience Source Type: research
Contextual fear memory modulates PSD95 phosphorylation, AMPAr subunits, PKMζ and PI3K differentially between adult and juvenile rats
Publication date: Available online 23 November 2018Source: Neurobiology of StressAuthor(s): Roseanna M. Zanca, Shirley Sanay, Jorge A. Avila, Edgar Rodriguez, Harry N. Shair, Peter A. SerranoAbstractIt is well known that young organisms do not maintain memories as long as adults, but the mechanisms for this ontogenetic difference are undetermined. Previous work has revealed that the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAr) subunits are trafficked into the synaptic membrane following memory retrieval in adults. Additionally, phosphorylated PSD-95-pS295 promotes AMPAr stabilization at the synaps...
Source: Neurobiology of Stress - November 24, 2018 Category: Neuroscience Source Type: research
