Stress alters social behavior and sensitivity to pharmacological activation of kappa opioid receptors in an age-specific manner in Sprague Dawley rats
Publication date: Available online 11 September 2018Source: Neurobiology of StressAuthor(s): Elena I. Varlinskaya, Linda Patia Spear, Marvin R. DiazAbstractThe dynorphin/kappa opioid receptor (DYN/KOR) system has been identified as a primary target of stress due to behavioral effects, such as dysphoria, aversion, and anxiety-like alterations that result from activation of this system. Numerous adaptations in the DYN/KOR system have also been identified in response to stress. However, whereas most studies examining the function of the DYN/KOR system have been conducted in adult rodents, there is growing evidence suggesting ...
Source: Neurobiology of Stress - September 11, 2018 Category: Neuroscience Source Type: research
Tauopathy and neurodegeneration: A role for stress
Publication date: Available online 1 September 2018Source: Neurobiology of StressAuthor(s): Jorge A. Sierra-Fonseca, Kristin L. GosselinkAbstractNeurodegenerative diseases are characterized by an irreversible and progressive loss of neuronal structure and function. While many alterations to normal cellular processes occur during neurodegeneration, a pathological accumulation of aggregated proteins constitutes a hallmark of several neurodegenerative disorders. Alzheimer's disease, specifically, is pathologically defined by the formation of amyloid plaques and tangles of hyperphosphorylated tau protein. Stress has emerged as...
Source: Neurobiology of Stress - September 1, 2018 Category: Neuroscience Source Type: research
Contradictory effects of erythropoietin on inhibitory synaptic transmission in left and right prelimbic cortex of mice
Publication date: Available online 28 August 2018Source: Neurobiology of StressAuthor(s): Andre Dik, Roja Saffari, Mingyue Zhang, Weiqi ZhangAbstractErythropoietin (EPO) has been shown to improve cognitive function in mammals as well as in patients of psychiatric diseases by directly acting on the brain. In addition, EPO attenuates the synaptic transmission and enhances short- and long-term synaptic plasticity in hippocampus of mice, although there are still many discrepancies between different studies. It has been suggested that the divergences of different studies take root in different in-vivo application schemata or in...
Source: Neurobiology of Stress - August 29, 2018 Category: Neuroscience Source Type: research
Neuroendocrine and neuroimmune adaptation to Chronic Escalating Distress (CED): A novel model of chronic stress
Publication date: Available online 18 August 2018Source: Neurobiology of StressAuthor(s): Dennis F. Lovelock, Terrence DeakAbstractAcute and chronic stress challenges have a profound influence on the development and expression of subsequent affective disorders, alcohol use disorders, and natural aging processes. These experiments examined adaptation in neuroimmune and neuroendocrine responses that occurred as a result of exposure to a novel model of chronic stress, termed chronic escalating distress (CED). This model involves exposure to highly predictable daily stress challenges involving a systematic escalation in both t...
Source: Neurobiology of Stress - August 18, 2018 Category: Neuroscience Source Type: research
The potential of calibrated fMRI in the understanding of stress in eating disorders
Publication date: Available online 18 August 2018Source: Neurobiology of StressAuthor(s): Christina E. Wierenga, Jason Lavender, Chelsea C. HaysAbstractEating disorders (ED), including Anorexia Nervosa (AN), Bulimia Nervosa (BN), and Binge Eating Disorder (BED), are medically dangerous psychiatric disorders of unknown etiology. Accumulating evidence supports a biopsychosocial model that includes genetic heritability, neurobiological vulnerability, and psychosocial factors, such as stress, in the development and maintenance of ED. Notably, stress hormones influence appetite and eating, and dysfunction of the physiological s...
Source: Neurobiology of Stress - August 18, 2018 Category: Neuroscience Source Type: research
Distinctive stress sensitivity and anxiety-like behavior in female mice: Strain differences matter
Publication date: Available online 16 August 2018Source: Neurobiology of StressAuthor(s): Renata Cristina Nunes Marchette, Maíra Assunção Bicca, Evelyn Cristina da Silva Santos, Thereza Christina Monteiro de LimaAbstractEpidemiologic studies have shown that the prevalence of stress-related mood disorders is higher in women, which suggests a different response of neuroendocrine circuits involved in the response to stressful events, as well as a genetic background influence. The aim of this study was to investigate the baseline differences in anxiety-like behaviors of females of two commonly used mice strains. Secondly, w...
Source: Neurobiology of Stress - August 16, 2018 Category: Neuroscience Source Type: research
Early life stress and environmental influences on the neurodevelopment of children with prenatal opioid exposure
We describe the literature on short and long-term neurodevelopmental outcomes of children with prenatal opioid exposure, highlighting sex differences and the role of early life stress. We conclude by prioritizing avenues for future research for this group of underserved women and their children at risk for neurodevelopmental delays. (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - August 15, 2018 Category: Neuroscience Source Type: research
Exercise, the diurnal cycle of cortisol and cognitive impairment in older adults
Publication date: Available online 12 August 2018Source: Neurobiology of StressAuthor(s): J. Tortosa-Martínez, C. Manchado-López, J.M. Cortell-Tormo, I. Chulvi-MedranoAbstractExercise has been shown to reduce the risk of developing Mild Cognitive Impairment and Alzheimer's disease as well as to improve cognition in healthy and cognitively impaired individuals. However, the mechanisms of these benefits are not well understood. The stress hypothesis suggests that the cognitive benefits attributed to exercise may partially be mediated by changes in the cortisol secretion pattern. Chronic stress may increase the risk of AD a...
Source: Neurobiology of Stress - August 13, 2018 Category: Neuroscience Source Type: research
Anti-stress neuropharmacological mechanisms and targets for addiction treatment: A translational framework
Publication date: Available online 11 August 2018Source: Neurobiology of StressAuthor(s): Mark K. GreenwaldAbstractStress-related substance use is a major challenge for treating substance use disorders. This selective review focuses on emerging pharmacotherapies with potential for reducing stress-potentiated seeking and consumption of nicotine, alcohol, marijuana, cocaine, and opioids (i.e., key phenotypes for the most commonly abused substances). I evaluate neuropharmacological mechanisms in experimental models of drug-maintenance and relapse, which translate more readily to individuals presenting for treatment (who have ...
Source: Neurobiology of Stress - August 12, 2018 Category: Neuroscience Source Type: research
Negative consequences of early-life adversity on substance use as mediated by corticotropin-releasing factor modulation of serotonin activity
Publication date: Available online 7 August 2018Source: Neurobiology of StressAuthor(s): Gina L. Forster, Eden M. Anderson, Jamie L. Scholl, Jodi L. Lukkes, Michael J. WattAbstractEarly-life adversity is associated with increased risk for substance abuse in later life, with women more likely to report past and current stress as a mediating factor in their substance use and relapse as compared to men. Preclinical models of neonatal and peri-adolescent (early through late adolescence) stress all support a direct relationship between experiences of early-life adversity and adult substance-related behaviors, and provide valuab...
Source: Neurobiology of Stress - August 7, 2018 Category: Neuroscience Source Type: research
REM sleep and safety signal learning in posttraumatic stress disorder: A preliminary study in military veterans
ConclusionTo our knowledge, this was the first study to examine the relationship between objective sleep and fear-potentiated startle performance in veterans with PTSD. Study methods were well tolerated by participants, supporting feasibility of the experimental design. Results indicated REM sleep was associated with both initial safety learning and subsequent safety recall. Taken together with previous studies in healthy controls, these preliminary results provide additional evidence suggesting REM sleep could play a mechanistic role in the maintenance of PTSD and thus identify a modifiable biological process to target in...
Source: Neurobiology of Stress - July 21, 2018 Category: Neuroscience Source Type: research
c-Fos mapping of brain regions activated by multi-modal and electric foot shock stress
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Xiaoxiao Lin, Christy A. Itoga, Sharif Taha, Ming H. Li, Ryan Chen, Kirolos Sami, Fulvia Berton, Walter Francesconi, Xiangmin XuAbstractReal-world stressors are complex and multimodal, involving physical, psychological, and social dimensions. However, the brain networks that mediate stress responses to these stimuli need to be further studied. We used c-Fos mapping in mice to characterize brain circuits activated by exposure to a single episode of multimodal stress (MMS), and compared these to circuits activated by electric foot shocks (EFS)....
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Network-based approaches to examining stress in the adolescent brain
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Tiffany C. Ho, Emily L. Dennis, Paul M. Thompson, Ian H. GotlibAbstractExposure to stress, particularly in periods of rapid brain maturation such as adolescence, can profoundly influence developmental processes that undergird the organization of structural and functional brain networks and that may mediate the association between stressful experiences and maladaptive outcomes. While studies in translational developmental neuroscience often focus on how specific brain regions or targeted connections are altered by stress and psychiatric diseas...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Roadmap for optimizing the clinical utility of emotional stress paradigms in human neuroimaging research
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): Timothy J. McDermott, Namik Kirlic, Robin L. AupperleAbstractThe emotional stress response is relevant to a number of psychiatric disorders, including posttraumatic stress disorder (PTSD) in particular. Research using neuroimaging methods such as functional magnetic resonance imaging (fMRI) to probe stress-related neural processing have provided some insights into psychiatric disorders. Treatment providers and individual patients would benefit from clinically useful fMRI paradigms that provide information about patients’ current brain state...
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
Editorial
Publication date: February 2018Source: Neurobiology of Stress, Volume 8Author(s): (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research
